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10 papers found.
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Increased Lipoprotein-associated phospholipase A2 activity portends an increased risk of resistant hypertension

Fanfang Zeng 0 Dongdan Zheng 2 0 Department of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital , Shenzhen , China 1 Department of Cardiology, Huizhou Municipal Central Hospital , 41st Eling North

Effects of rosuvastatin combined with fasudil therapy on rabbits with dyslipidemia

Background Present study was conducted to investigate the effects of rosuvastatin combined with fasudil on rabbits with dyslipidemia. Methods Dyslipidemia model of rabbits were produced by prescribing atherogenic diet for 2 weeks. Thereafter, 40 rabbits with dyslipidemia were randomly and evenly divided into four groups as follow: untreated group (orally prescribed 3 ml of normal...

Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats

statistic analyses, and DL and WM designed this study and DZ wrote this article. All authors read and approved the final manuscript. Authors information Dongdan Zheng, Qing Liang and FanFang Zeng are co

Increased Hs-CRP/adiponectin ratio is associated with increase carotid intima-media thickness

Background High sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression. The purpose of our study was to investigate the value of Hs-CRP and ANP ratio (Hs-CRP/APN ratio) on evaluating atherosclerosis progression. Method One hundred sixty consecutive participants underwent...

Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia

Zheng 0 Weixing Han 1 0 The Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong Province , China 1 The First Affiliated Hospital of Anhui Medical

Baseline elevated Lp-PLA2 is associated with increased risk for re-stenosis after stent placement

study and WM helped to revise final version of current manuscript. All authors read and approved the final manuscript. Authors information Dongdan Zheng, FanFang Zeng, Anping Cai: co-first authors. 1

Atorvastatin Treatment of Rats with Ischemia-Reperfusion Injury Improves Adipose-Derived Mesenchymal Stem Cell Migration and Survival via the SDF-1α/CXCR-4 Axis

Background Adipose-derived mesenchymal stem cells (ASCs) transplantation is a promising approach for myocardium repair. Promotion of ASCs migration and survival is the key for improving ASCs efficiency. SDF-1α is a critical factor responsible for ASCs migration and survival. Atorvastatin (Ator) is capable of up-regulating SDF-1α. Therefore, we're going to investigate whether ASCs...

Inhibition of ROS-Activated p38MAPK Pathway is Involved in the Protective Effect of H2S Against Chemical Hypoxia-Induced Inflammation in PC12 Cells

We have demonstrated the neuroprotection of hydrogen sulfide (H2S) against chemical hypoxia-induced injury by inhibiting p38MAPK pathway. The present study attempts to evaluate the effect of H2S on chemical hypoxia-induced inflammation responses and its mechanisms in PC12 cells. We found that treatment of PC12 cells with cobalt chloride (CoCl2, a hypoxia mimetic agent) enhanced...

SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects

Background The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on SDF-1α expression in rats with AMI. Methods Male Sprague–Dawley rats were underwent permanent coronary artery ligation and randomly assigned into four groups as...

Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury by Inhibiting ROS-Activated ERK1/2 and p38MAPK Signaling Pathways in PC12 Cells

Hydrogen sulfide (H2S) has been proposed as a novel neuromodulator and neuroprotective agent. Cobalt chloride (CoCl2) is a well-known hypoxia mimetic agent. We have demonstrated that H2S protects against CoCl2-induced injuries in PC12 cells. However, whether the members of mitogen-activated protein kinases (MAPK), in particular, extracellular signal-regulated kinase1/2(ERK1/2...