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MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3

, Henan Provincial People Hospital , No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, Henan , China 1 Dongsheng Li Accumulating evidences suggest that neuroinflammation is a pathological hallmark of

Morphology and composition controlled synthesis of flower-like silver nanostructures

Flower-like silver nanostructures with controlled morphology and composition were prepared through wet-chemical synthesis. The reaction rate is simply manipulated by the amount of catalyzing agent ammonia added which is the key point to determine the ratio of hexagonal close-packed (HCP) to face-centered cubic (FCC) phase in silver nanostructures. The existence of formic acid...

Tunable surface plasmon resonance frequencies of monodisperse indium tin oxide nanoparticles by controlling composition, size, and morphology

Monodisperse indium tin oxide nanoparticles (ITO NPs) with high crystallinity have been synthesized by the rapid thermal injection method and the seed-mediated growth method. We demonstrate that the surface plasmon resonance (SPR) frequencies of ITO NPs can be manipulated from 1,600 to 1,993 nm in near-infrared band by controlling the composition, size, and morphology. The doping...

Temperature dependence of sensitized Er3+ luminescence in silicon-rich oxynitride films

The temperature dependence of sensitized Er3+ emission via localized states and silicon nanoclusters has been studied to get an insight into the excitation and de-excitation processes in silicon-rich oxynitride films. The thermal quenching of Er3+ luminescence is elucidated by terms of decay time and effective excitation cross section. The temperature quenching of Er3+ decay time...

Binding of the eukaryotic translation elongation factor 1A with the 5’UTR of HIV-1 genomic RNA is important for reverse transcription

Background The cellular protein eukaryotic translation elongation factor 1A (eEF1A) binds to aminoacylated transfer RNAs and delivers them to the ribosome during translation. eEF1A also binds to RNA secondary structures present in genomes of several RNA viruses and plays important roles in their replication. As a RNA binding protein, whether eEF1A can bind with HIV-1 genomic RNA...

Evolution of the sensitized Er3+ emission by silicon nanoclusters and luminescence centers in silicon-rich silica

The structural and optical properties of erbium-doped silicon-rich silica samples containing different Si concentrations are studied. Intense photoluminescence (PL) from luminescence centers (LCs) and silicon nanoclusters (Si NCs), which evolves with annealing temperatures, is obtained. By modulating the silicon concentrations in samples, the main sensitizers of Er3+ ions can be...

The Eukaryotic Elongation Factor 1A Is Critical for Genome Replication of the Paramyxovirus Respiratory Syncytial Virus

The eukaryotic translation factor eEF1A assists replication of many RNA viruses by various mechanisms. Here we show that down-regulation of eEF1A restricts the expression of viral genomic RNA and the release of infectious virus, demonstrating a biological requirement for eEF1A in the respiratory syncytial virus (RSV) life cycle. The key proteins in the replicase/transcriptase...

Shape and phase control of CdS nanocrystals using cationic surfactant in noninjection synthesis

Yu Zou 0 Dongsheng Li 0 Deren Yang 0 0 State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, People's Republic of China

The coupling between localized surface plasmons and excitons via Purcell effect

The coupling between localized surface plasmons (LSPs) within silver nanostructures and excitons in a silicon-rich silicon nitride (SiN x ) matrix has been demonstrated via the Purcell effect. A simple model is employed for the estimation of the Purcell factor as well as the average position of excitons within a luminescence matrix. The estimated average position of the excitons...

Energy transfer from luminescent centers to Er3+ in erbium-doped silicon-rich oxide films

The energy transfer mechanism between luminescent centers (LCs) and Er3+ in erbium-doped silicon-rich oxide (SROEr) films prepared by electron beam evaporation is investigated. Intense photoluminescence of the LCs (weak oxygen bonds, neutral oxygen vacancies, and Si=O states) within the active matrixes is obtained. Fast energy transfer from Si=O states to Er3+ takes advantage in...

Identification of a Cryptic Prokaryotic Promoter within the cDNA Encoding the 5′ End of Dengue Virus RNA Genome

of a Cryptic Prokaryotic Promoter within the cDNA Encoding the 59 End of Dengue Virus RNA Genome Dongsheng Li 0 John Aaskov 0 William B. Lott 0 Eng Eong Ooi, Duke-National University of Singapore

A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1

Background Previously we described a transdominant negative mutant of the HIV-1 Tat protein, termed Nullbasic, that downregulated the steady state levels of unspliced and singly spliced viral mRNA, an activity caused by inhibition of HIV-1 Rev activity. Nullbasic also altered the subcellular localizations of Rev and other cellular proteins, including CRM1, B23 and C23 in a Rev...

Noninjection Synthesis of CdS and Alloyed CdSxSe1−xNanocrystals Without Nucleation Initiators

Yu Zou 0 Dongsheng Li 0 Deren Yang 0 0 Y. Zou D. Li (&) D. Yang State Key Laboratory of Silicon Materials and Department of Materials Science and Engineering, Zhejiang University , 310027 Hangzhou

The modulation on luminescence of Er3+-doped silicon-rich oxide films by the structure evolution of silicon nanoclusters

A series of silicon-rich oxide (SRO) and erbium-doped SRO (SROEr) films imbedded with structural tunable silicon nanoclusters (Si NCs) have been fabricated using sputtering followed by post-annealing. The coalescence of Si NCs is found in the films with large Si excess. The energy transfer rate between Si NCs and Er3+ is enhanced, but the luminescence efficiencies of both Si NCs...

Expression of AQP5 and AQP8 in human colorectal carcinoma and their clinical significance

Background The aquaporins (AQPs) are a family of small membrane transport proteins whose overexpression has been implicated in tumorigenesis. However, the expression of AQP5 and AQP8 in colorectal cancer and the clinical significance remain unexplored. This study aimed to detect the expression of AQP5 and AQP8 in clinical samples of colorectal cancer and analyze the correlations...

Overexpression of PRMT6 does not suppress HIV-1 Tat transactivation in cells naturally lacking PRMT6

Haran Sivakumaran 0 Min-Hsuan Lin 0 Ann Apolloni Vincent Cutillas Hongping Jin Dongsheng Li Ting Wei David Harrich 0 Equal contributors Queensland Institute of Medical Research, Molecular Virology

A Chitin-Like Component on Sclerotic Cells of Fonsecaea pedrosoi Inhibits Dectin-1-Mediated Murine Th17 Development by Masking β-Glucans

Fonsecaea pedrosoi (F. pedrosoi), a major agent of chromoblastomycosis, has been shown to be recognized primarily by C-type lectin receptors (CLRs) in a murine model of chromoblastomycosis. Specifically, the β-glucan receptor, Dectin-1, mediates Th17 development and consequent recruitment of neutrophils, and is evidenced to have the capacity to bind to saprophytic hyphae of F...

Dynamical Properties for a Class of Fourth-Order Nonlinear Difference Equations

We consider the dynamical properties for a kind of fourth-order rational difference equations. The key is for us to find that the successive lengths of positive and negative semicycles for nontrivial solutions of this equation periodically occur with same prime period 5. Although the period is same, the order for the successive lengths of positive and negative semicycles is...

Defective Interfering Viral Particles in Acute Dengue Infections

While much of the genetic variation in RNA viruses arises because of the error-prone nature of their RNA-dependent RNA polymerases, much larger changes may occur as a result of recombination. An extreme example of genetic change is found in defective interfering (DI) viral particles, where large sections of the genome of a parental virus have been deleted and the residual sub...

MBL-Mediated Opsonophagocytosis of Candida albicans by Human Neutrophils Is Coupled with Intracellular Dectin-1-Triggered ROS Production

Mannan-binding lectin (MBL), a lectin homologous to C1q, greatly facilitates C3/C4-mediated opsonophagocytosis of Candida albicans (C. albicans) by human neutrophils, and has the capacity to bind to CR1 (CD35) expressed on circulating neutrophils. The intracellular pool of neutrophil Dectin-1 plays a critical role in stimulating the reactive oxygen species (ROS) generation...