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18 papers found.
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Patterns of Insulin Concentration During the OGTT Predict the Risk of Type 2 Diabetes in Japanese Americans

TOMOSHIGE HAYASHI PHD EDWARD J. BOYKO KYOKO KOGAWA SATO PHD MARGUERITE J. MCNEELY DONNA L. LEONETTI PHD STEVEN E. KAHN MB CHB WILFRED Y. FUJIMOTO E p i d e m i o l o g y / H e a l t h OBJECTIVEdTo

Change in Visceral Adiposity Independently Predicts a Greater Risk of Developing Type 2 Diabetes Over 10 Years in Japanese Americans

PANDORA L. WANDER EDWARD J. BOYKO DONNA L. LEONETTI PHD MARGUERITE J. MCNEELY STEVEN E. KAHN MB CHB WILFRED Y. FUJIMOTO E p i d e m i o l o g y / H e a l t h OBJECTIVEdVisceral adiposity is an

Associations Among Visceral Fat, All-Cause Mortality, and Obesity-Related Mortality in Japanese Americans

MARGUERITE J. MCNEELY JANE B. SHOFER MS DONNA L. LEONETTI PHD WILFRED Y. FUJIMOTO EDWARD J. BOYKO E p i d e m i o l o g y / H e a l t h OBJECTIVEdThe study objective was to examine the associations

HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis

Aims/Hypothesis The relationships between smoking and glycaemic variables have not been well explored. We compared HbA1c, fasting plasma glucose (FPG) and 2 h plasma glucose (2H-PG) in current, ex- and never-smokers. Methods This meta-analysis used individual data from 16,886 men and 18,539 women without known diabetes in 12 DETECT-2 consortium studies and in the French Data from ...

Visceral Adiposity, Not Abdominal Subcutaneous Fat Area, Is Associated With an Increase in Future Insulin Resistance in Japanese Americans

OBJECTIVE—Visceral adiposity is generally considered to play a key role in the metabolic syndrome. We sought to determine whether greater visceral adiposity directly measured by computed tomography (CT) is associated with increased future insulin resistance independent of other adipose depots. RESEARCH DESIGN AND METHODS— We followed 306 nondiabetic Japanese Americans over 10–11 ...

Minimum Waist and Visceral Fat Values for Identifying Japanese Americans at Risk for the Metabolic Syndrome: Response to Oda

. TOMOSHIGE HAYASHI, MD, PHD1 EDWARD J. BOYKO, MD, MPH2,3 MARGUERITE J. MCNEELY, MD3 DONNA L. LEONETTI, PHD, MPH4 STEVEN E. KAHN, MB, CHB3 WILFRED Y. FUJIMOTO, MD3 References 1. Oda E

Minimum Waist and Visceral Fat Values for Identifying Japanese Americans at Risk for the Metabolic Syndrome

OBJECTIVE—Japanese American is an ethnic group with a high risk for type 2 diabetes, which is linked to the metabolic syndrome. Central adiposity is considered to play a key role in the metabolic syndrome. Not known are the optimal cut point values for central and visceral adiposity to identify Japanese Americans at risk for the metabolic syndrome. RESEARCH DESIGN AND METHODS—Study ...

Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-h Glucose Levels: Response to DeFronzo and Abdul-Ghani

. BOYKO, MD, MPH6 DONNA L. LEONETTI, PHD7 MARGUERITE J. MCNEELY, MD2 WILFRED Y. FUJIMOTO, MD2 STEVEN E. KAHN, MB, CHB1,2 References 1. Retnakaran R, Shen S, Hanley AJ, Vuksan V

Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-h Glucose Levels

KRISTINA M. UTZSCHNEIDER RONALD L. PRIGEON MIRJAM V. FAULENBACH JENNY TONG DARCY B. CARR MS EDWARD J. BOYKO DONNA L. LEONETTI PHD MARGUERITE J. MCNEELY WILFRED Y. FUJIMOTO STEVEN E. KAHN MB CHB C a

Comparison of a Clinical Model, the Oral Glucose Tolerance Test, and Fasting Glucose for Prediction of Type 2 Diabetes Risk in Japanese Americans

OBJECTIVE—To test the validity of a published clinical model for predicting incident diabetes in Japanese Americans. RESEARCH DESIGN AND METHODS—A total of 465 nondiabetic Japanese Americans (243 men, 222 women), aged 34–75 years, were studied at baseline and at 5–6 years. A total of 412 subjects were studied at 10 years. The clinical model included age, sex, ethnicity, BMI, ...

Visceral Adiposity and the Risk of Impaired Glucose Tolerance: A prospective study among Japanese Americans

OBJECTIVE—Greater visceral adiposity, higher insulin resistance, and impaired insulin secretion increase the risk of type 2 diabetes. Whether visceral adiposity increases risk of impaired glucose tolerance (IGT) independent of other adipose depots, insulin resistance, and insulin secretion is not known. RESEARCH DESIGN AND METHODS—Study subjects included 128 Japanese Americans with ...

Insulin, C-Peptide, and Leptin Concentrations Predict Increased Visceral Adiposity at 5- and 10-Year Follow-Ups in Nondiabetic Japanese Americans

We prospectively examined the relationship between leptin and markers of insulin resistance and secretion and future visceral adipose tissue accumulation. In this study, 518 nondiabetic Japanese-American men and women underwent the following measurements at baseline and at 5- and 10-year follow-ups: plasma glucose and insulin measured after an overnight fast and during a 75-g oral ...

Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans

. Chandler 0 Donna L. Leonetti 5 Philippa J. Talmud 4 Steve E. Humphries 4 Wilfred Y. Fujimoto 3 0 Laboratory Medicine, Harborview Medical Center Uni- versity of Washington , Seattle, Washington; the 1

Abnormal Glucose Tolerance and Increased Risk for Cardiovascular Disease in Japanese-Americans With Normal Fasting Glucose

OBJECTIVE— To compare the American Diabetes Association (ADA) fasting glucose and the World Health Organization (WHO) oral glucose tolerance test (OGTT) criteria for diagnosing diabetes and detecting people at increased risk for cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS— Study subjects were 596 Japanese-Americans. Fasting insulin, lipids, and C-peptide levels; ...

A Reduced-Fat Diet and Aerobic Exercise in Japanese Americans With Impaired Glucose Tolerance Decreases Intra-Abdominal Fat and Improves Insulin Sensitivity but not β-Cell Function

Lifestyle modification reduces the risk of developing type 2 diabetes and may have its effect through improving insulin sensitivity, β-cell function, or both. To determine whether diet and exercise improve insulin sensitivity and/or β-cell function and to evaluate these effects over time, we quantified insulin sensitivity and the acute insulin response to glucose (AIRg) in 62 ...

Fasting Insulin Level Underestimates Risk of Non-lnsulin-dependent Diabetes Mellitus Due to Confounding by Insulin Secretion

Fasting insulin has been used as a surrogate measure of insulin sensitivity in studies of non-insulin-dependent diabetes mellitus (NIDDM) risk, but the fasting insulin-NIDDM association may be confounded by insulin secretion, which correlates negatively with NIDDM risk and positively with fasting insulin level. In a prospective 5-year study of 137 nondiabetic Japanese-American men ...