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A PROgramme of Lifestyle Intervention in Families for Cardiovascular risk reduction (PROLIFIC Study): design and rationale of a family based randomized controlled trial in individuals with family history of premature coronary heart disease

Nikhil Tandon 3 Dorairaj Prabhakaran 2 0 Institute of Cardiovascular and Medical Sciences, University of Glasgow , Glasgow , UK 1 Sree Chitra Tirunal Institute of Medical Sciences and Technology

Comparison of multiple obesity indices for cardiovascular disease risk classification in South Asian adults: The CARRS Study

Background We comparatively assessed the performance of six simple obesity indices to identify adults with cardiovascular disease (CVD) risk factors in a diverse and contemporary South Asian population. Methods 8,892 participants aged 20–60 years in 2010–2011 were analyzed. Six obesity indices were examined: body mass index (BMI), waist circumference (WC), waist-height ratio ...

Association of Hip Bone Mineral Density and Body Composition in a Rural Indian Population: The Andhra Pradesh Children and Parents Study (APCAPS)

Background Fat mass is variably associated with bone mass, possibly due to differential mechanical and biological effects of fat mass. We examined the association of fat mass with bone mass in a lean population. Objective To investigate association between hip bone mineral density and fat and lean mass in a cross-sectional study from southern India. Design The Andhra Pradesh ...

Prevalence of chronic kidney disease and risk factors for its progression: A cross-sectional comparison of Indians living in Indian versus U.S. cities

Background While data from the latter part of the twentieth century consistently showed that immigrants to high-income countries faced higher cardio-metabolic risk than their counterparts in low- and middle-income countries, urbanization and associated lifestyle changes may be changing these patterns, even for conditions considered to be advanced manifestations of cardio-metabolic ...

Task shifting of frontline community health workers for cardiovascular risk reduction: design and rationale of a cluster randomised controlled trial (DISHA study) in India

. DISHA study investigators and study team Centre for Chronic Disease Control, Delhi: Dr. Dorairaj Prabhakaran, PI; Dr. Sathya Prakash Manimunda, Co-PI; Dr. Panniyammakal Jeemon, Co-I; Dr. Dimple Kondal

Development and Validation of a Clinical and Computerised Decision Support System for Management of Hypertension (DSS-HTN) at a Primary Health Care (PHC) Setting

BackgroundHypertension remains the top global cause of disease burden. Decision support systems (DSS) could provide an adequate and cost-effective means to improve the management of hypertension at a primary health care (PHC) level in a developing country, nevertheless evidence on this regard is rather limited. MethodsDevelopment of DSS software was based on an algorithmic approach ...

Measuring Social Networks for Medical Research in Lower-Income Settings

Social networks are believed to affect health-related behaviors and health. Data to examine the links between social relationships and health in low- and middle-income country settings are limited. We provide guidance for introducing an instrument to collect social network data as part of epidemiological surveys, drawing on experience in urban India. We describe development and ...

Nutritional profile of Indian vegetarian diets – the Indian Migration Study (IMS)

participants of the Indian Migration Study. The Indian Migration Study group comprises: New Delhi: K. Srinath Reddy, Dorairaj Prabhakaran, Tulsi Patel, Lakshmy Ramakrishnan, Ruby Gupta, Tanica Lyngdoh; Lucknow

The Association between a Vegetarian Diet and Cardiovascular Disease (CVD) Risk Factors in India: The Indian Migration Study

. Acknowledgments We are grateful to the local investigators, fieldworkers and the participants of the Indian Migration Study. The Indian Migration Study group comprises: New Delhi: K. Srinath Reddy, Dorairaj ... Prabhakaran, Tulsi Patel, Lakshmy Ramakrishnan, Ruby Gupta, Tanica Lyngdoh; Lucknow: R.C. Ahuja, R.K. Saran; Nagpur: Prashant Joshi, N.M. Thakre; Hyderabad: K.V.R. Sarma, S. Mohan Das, R.K Jain, S.S. Potnis

Adolescent undernutrition and early adulthood bone mass in an urbanizing rural community in India

Summary The long-term effects on bone health of nutritional status in adolescence are unclear. The impact of adolescent and current body mass on bone mass in young adulthood in rural India was assessed. Current lean mass was a more important determinant of bone mass than thinness during adolescence in this population. Purpose/introduction Adolescence is a crucial period for ...

Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity

-Shlomo Ruby Gupta Bharati Kulkarni Dorairaj Prabhakaran George Davey Smith Jonathan Wells Shah Ebrahim Sanjay Kinra 0 Clinical Research Department, London School of Hygiene & Tropical Medicine , Keppel

Is the Association between Vitamin D and Cardiovascular Disease Risk Confounded by Obesity? Evidence from the Andhra Pradesh Children and Parents Study (APCAPS)

Background Evidence of an association between serum vitamin D and cardiovascular disease risk is inconsistent and comes predominantly from studies in high-income settings. We assessed the association between serum levels of 25-hydroxyvitamin D3 (25(OH)D) and cardiovascular disease risk factors in a population of young Indian adults. Methods Cross-sectional analyses of data from ...

A cross-sectional study of the prevalence and correlates of tobacco Use in Chennai, Delhi, and Karachi: data from the CARRS study

Mohammed K. Ali Dimple Kondal Hassan M. Khan Roopa Shivashankar Rajendra Pradeepa Deepa Mohan Zafar Fatmi Muhammad M. Kadir Nikhil Tandon Viswanathan Mohan KM Venkat Narayan Dorairaj Prabhakaran 0 Department ... , Vanderbilt University, Emory University, PHFI, NICHD, or the NIH. COECARRS Surveillance Investigators Group. Steering Committee: Dorairaj Prabhakaran, K. M. Venkat Narayan, K Srinath Reddy, Nikhil Tandon, V

‘Decision support system (DSS) for prevention of cardiovascular disease (CVD) among hypertensive (HTN) patients in Andhra Pradesh, India’ – a cluster randomised community intervention trial

Background Very few studies having decision support systems as an intervention report on patient outcomes for cardiovascular disease in the Western world. The potential role of decision support system for the management of blood pressure among Indian hypertensives remains unclear. We propose a cluster randomised trial that aims to test the effectiveness and cost effectiveness of ...

A cluster-randomized controlled trial to evaluate the effects of a simplified cardiovascular management program in Tibet, China and Haryana, India: study design and rationale

Background In resource-poor areas of China and India, the cardiovascular disease burden is high, but availability of and access to quality healthcare is limited. Establishing a management scheme that utilizes the local infrastructure and builds healthcare capacity is essential for cardiovascular disease prevention and management. The study aims to develop, implement, and evaluate ...

Definitions and potential health benefits of the Mediterranean diet: views from experts around the world

Forouhi 6 Shweta Khandelwal 5 Dorairaj Prabhakaran 5 Dariush Mozaffarian 4 Michel de Lorgeril 3 0 CIBER-OBN, Instituto de Salud Carlos III , Madrid , Spain 1 Department of Preventive Medicine and Public ... , particularly, Mediterranean countries. Mediterranean diet: an Indian perspective Shweta Khandelwal, Dorairaj Prabhakaran (Figures 6 and 7) The term Mediterranean Diet is usually employed to indicate the

Global Cardiovascular Research Output, Citations, and Collaborations: A Time-Trend, Bibliometric Analysis (1999–2008)

Introduction Health research is one mechanism to improve population-level health and should generally match the health needs of populations. However, there have been limited data to assess the trends in national-level cardiovascular research output, even as cardiovascular disease [CVD] has become the leading cause of morbidity and mortality worldwide. Materials and Methods We ...

Association between Milk and Milk Product Consumption and Anthropometric Measures in Adult Men and Women in India: A Cross-Sectional Study

Background The nutritional aetiology of obesity remains unclear, especially with regard to the role of dairy products in developing countries. Objective To examine whether milk/milk product consumption is associated with obesity and high waist circumference among adult Indians. Methods Information on plain milk, tea, curd and buttermilk/lassi consumption assessed using a Food ...

A multifaceted strategy using mobile technology to assist rural primary healthcare doctors and frontline health workers in cardiovascular disease risk management: protocol for the SMARTHealth India cluster randomised controlled trial

Background Blood Pressure related disease affected 118 million people in India in the year 2000; this figure will double by 2025. Around one in four adults in rural India have hypertension, and of those, only a minority are accessing appropriate care. Health systems in India face substantial challenges to meet these gaps in care, and innovative solutions are needed. Methods We ...

Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study

Background The decreased number and senescence of circulating endothelial progenitor cells (EPCs) are considered markers of vascular senescence associated with aging, atherosclerosis, and coronary artery disease (CAD) in elderly. In this study, we explore the role of vascular senescence in premature CAD (PCAD) in a developing country by comparing the numerical status and senescence ...