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13 papers found.
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Highly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility

S. Goodin. Data curation: Douglas S. Goodin. Formal analysis: Douglas S. Goodin, Pouya Khankhanian, Nicolas Vince. Investigation: Douglas S. Goodin. Methodology: Douglas S. Goodin, Pouya ... Khankhanian, Pierre-Antoine Gourraud, Nicolas Vince. 20 / 23 Software: Douglas S. Goodin, Pouya Khankhanian. Supervision: Douglas S. Goodin. Visualization: Douglas S. Goodin. Writing ± original draft

Single Nucleotide Polymorphism (SNP)-Strings: An Alternative Method for Assessing Genetic Associations

Background Genome-wide association studies (GWAS) identify disease-associations for single-nucleotide-polymorphisms (SNPs) from scattered genomic-locations. However, SNPs frequently reside on several different SNP-haplotypes, only some of which may be disease-associated. This circumstance lowers the observed odds-ratio for disease-association. Methodology/Principal Findings Here we ...

The Genetic and Environmental Bases of Complex Human-Disease: Extending the Utility of Twin-Studies

Making only the assumption that twins are representative of the population from which they are drawn, we here develop a simple mathematical model (using widely available epidemiological information) that sheds considerable light on the pathogenesis of complex human diseases. Specifically, for the case of multiple sclerosis (MS), we demonstrate that the vast majority of patients ...

Incidence and course of depression in multiple sclerosis in the multinational BEYOND trial

Early experience in MS generated concerns that interferon beta treatment might provoke onset or worsening of depression. The objective of the study was to compare depression incidence in relapsing–remitting MS patients receiving interferon beta-1b (IFNB-1b) or glatiramer acetate (GA) in the BEYOND trial. 891/897 (99 %) of English, French, Spanish and Italian speakers among 2244 ...

The genetic basis of multiple sclerosis: a model for MS susceptibility

Douglas S Goodin 0 0 Department of Neurology, University of California , San Francisco, CA , USA Results: For the large majority of cases (possibly all), MS develops, in part, because an individual

Causes of Death among Commercially Insured Multiple Sclerosis Patients in the United States

Background Information on causes of death (CODs) for patients with multiple sclerosis (MS) in the United States is sparse and limited by standard categorizations of underlying and immediate CODs on death certificates. Prior research indicated that excess mortality among MS patients was largely due to greater mortality from infectious, cardiovascular, or pulmonary causes. Objective ...

The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis

Background MS pathogenesis seems to involve both genetic susceptibility and environmental risk factors. Three sequential factors are implicated in the environmental risk. The first acts near birth, the second acts during childhood, and the third acts long thereafter. Two candidate factors (vitamin D deficiency and Epstein-Barr viral infection) seem well suited to the first two ...

Predictors of disease activity in 857 patients with MS treated with interferon beta-1b

Multiple sclerosis (MS) is a chronic demyelinating neurodegenerative disease of the CNS that requires long-term treatment. The identification of patient characteristics that can help predict disease outcomes could improve care for patients with MS. The objective of this study is to identify predictors of disease activity in patients from the BEYOND trial. This regression analysis ...

Retinal Axonal Loss Begins Early in the Course of Multiple Sclerosis and Is Similar between Progressive Phenotypes

Background To determine whether retinal axonal loss is detectable in patients with a clinically isolated syndrome (CIS), a first clinical demyelinating attack suggestive of multiple sclerosis (MS), and examine patterns of retinal axonal loss across MS disease subtypes. Methodology/Principal Findings Spectral-domain Optical Coherence Tomography was performed in 541 patients with MS, ...

Establishing Long-Term Efficacy in Chronic Disease: Use of Recursive Partitioning and Propensity Score Adjustment to Estimate Outcome in MS

Context Establishing the long-term benefit of therapy in chronic diseases has been challenging. Long-term studies require non-randomized designs and, thus, are often confounded by biases. For example, although disease-modifying therapy in MS has a convincing benefit on several short-term outcome-measures in randomized trials, its impact on long-term function remains uncertain. ...

Switching Multiple Sclerosis Patients with Breakthrough Disease to Second-Line Therapy

Background Multiple sclerosis (MS) patients with breakthrough disease on immunomodulatory drugs are frequently offered to switch to natalizumab or immunosuppressants. The effect of natalizumab monotherapy in patients with breakthrough disease is unknown. Methods This is an open-label retrospective cohort study of 993 patients seen at least four times at the University of California ...

Variability in detection and quantification of interferon β-1b–induced neutralizing antibodies

BackgroundInterferon-beta (IFNB) therapy for multiple sclerosis can lead to the induction of neutralizing antibodies (NAbs) against IFNB. Various methods are used for detection and quantification of NAbs.MethodsBlood samples from 125 IFNB-1b–treated patients, which were tested NAb negative or NAb positive after conclusion of a clinical study, were retested three years after first ...

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause of neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report the results of a genome-wide association study performed in a 1000 prospective case series of well-characterized individuals with MS and group-matched controls using the ...