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Bone Phenotype Assessed by HRpQCT and Associations with Fracture Risk in the GLOW Study

Lifecourse Epidemiology Unit, University of Southampton , Southampton , UK 2 & E. M. Dennison 3 NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford , UK The epidemiology and

Epidemiology of Sarcopenia: Determinants Throughout the Lifecourse

Sarcopenia is an age-related syndrome characterised by progressive and generalised loss of skeletal muscle mass and strength; it is a major contributor to the risk of physical frailty, functional impairment in older people, poor health-related quality of life and premature death. Many different definitions have been used to describe sarcopenia and have resulted in varying estimates ...

Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review

Summary This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be ...

Non-invasive Assessment of Lower Limb Geometry and Strength Using Hip Structural Analysis and Peripheral Quantitative Computed Tomography: A Population-Based Comparison

. J. Denison, K. A. Jameson, M. H. Edwards, A. A. Sayer, P. Taylor, C. Cooper, E. M. Dennison) declare no conflict of interest Human and Animal Rights and Informed Consent Ethical permission for the ... Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford , UK 1 MRC Lifecourse Epidemiology Unit, (University of Southampton) Southampton General Hospital , Southampton SO16 6YD , UK 2 & E. M

Where now with NICE?

E. M. Dennison C. Cooper 0 ) MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital , Southampton SO16 6YD, UK - The National Institute of Clinical Excellence

Impact of clinical osteoarthritis of the hip, knee and hand on self-rated health in six European countries: the European Project on OSteoArthritis

Purpose Osteoarthritis (OA) has been shown to be associated with decreased physical function, which may impact upon a person’s self-rated health (SRH). Only a few studies have examined the association between OA and SRH in the general population, but to date none have used a clinical definition of OA. The objectives are: (1) To examine the cross-sectional association between ...

Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance?

Aims/hypothesis Previous studies have suggested that the high bone density often observed in type 2 diabetic patients may be explained by insulin resistance. We explored this hypothesis in the Hertfordshire Cohort Study. Methods A total of 465 men and 444 women aged 59 to 71 years and with no prior diagnosis of diabetes attended a clinic where a glucose tolerance test was performed ...

Birth Weight, Infant Weight Gain, and Cause-specific Mortality: The Hertfordshire Cohort Study

Low birth weight, a marker of adverse intrauterine circumstances, is known to be associated with a range of disease outcomes in later life, including coronary heart disease, hypertension, type 2 diabetes, and osteoporosis. However, it may also decrease the risk of other common conditions, most notably neoplastic disease. The authors describe the associations between birth weight, ...