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16 papers found.
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International migration patterns of Red-throated Loons (Gavia stellata) from four breeding populations in Alaska

. Geological Survey Alaska Science Center [ 59 ]. Author Contributions Conceptualization: Joel A. Schmutz. Data curation: Sarah E. McCloskey, Brian D. Uher-Koch. Formal analysis: Sarah E. McCloskey ... . Funding acquisition: Joel A. Schmutz. Investigation: Sarah E. McCloskey, Brian D. Uher-Koch, Joel A. Schmutz, Thomas F. Fondell. Methodology: Sarah E. McCloskey, Brian D. Uher-Koch, Joel A. Schmutz, Thomas

Metabolic shift in density-dependent stem cell differentiation

Vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) are a valuable source for cell- and tissue-based therapeutic strategies. During the optimization of endothelial cell (EC) inductions from mouse ESCs using our staged and chemically-defined induction methods, we found that cell seeding density but not VEGF treatment between 10 ng/mL and 40 ng/mL was a...

Epidemiology of fractures in Armenia: development of a country-specific FRAX model and comparison to its surrogate

Summary Fracture probabilities derived from the surrogate FRAX model for Armenia were compared to those from the model based on regional estimates of the incidence of hip fracture. Disparities between the surrogate and authentic FRAX models indicate the importance of developing country-specific FRAX models. Despite large differences between models, differences in the rank order...

Multifactorial Optimizations for Directing Endothelial Fate from Stem Cells

Embryonic stem cells (ESC) and induced pluripotent stem (iPS) cells are attractive in vitro models of vascular development, therapeutic angiogenesis, and tissue engineering. However, distinct ESC and iPS cell lines respond differentially to the same microenvironmental factors. Developing improved/optimized differentiation methodologies tailored/applicable in a number of distinct...

Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting

Summary Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap. Identification of patients who are at particularly high risk will help clinicians target appropriate treatment more precisely and cost-effectively, and should be the focus of future...

The US FRAX® filter: avoiding confusion or hindering progress?

I don’t do quagmiresDonald RumsfeldUS Department of Defence News Briefing, July 2003“The leadership of NOF and ISCD has decided after long and careful consideration that a FRAX® filter should be available, and this will happen in the USA.” So speak the proponents of the US FRAX® filter. Unfortunately, the careful consideration appears to have been driven more by threat than...

S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion

Neoplastic growth is associated with increased polyamine biosynthetic activity and content. Tumor promoter treatment induces the rate-limiting enzymes in polyamine biosynthesis, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC), and targeted ODC overexpression is sufficient for tumor promotion in initiated mouse skin. We generated a mouse model with...

FRAX™ and the assessment of fracture probability in men and women from the UK

Bone Diseases, University of Sheffield Medical School , Beech Hill Road, Sheffield S10 2RX, UK 2 E. McCloskey Osteoporosis Centre, Northern General Hospital , Sheffield, UK Summary A fracture risk

‘Sink or swim’: an evaluation of the clinical characteristics of individuals with high bone mass

Summary High bone mineral density on routine dual energy X-ray absorptiometry (DXA) may indicate an underlying skeletal dysplasia. Two hundred fifty-eight individuals with unexplained high bone mass (HBM), 236 relatives (41% with HBM) and 58 spouses were studied. Cases could not float, had mandible enlargement, extra bone, broad frames, larger shoe sizes and increased body mass...

Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin

The limited induction of spermidine/spermine N1- acetyltransferase (SSAT) activity has been implicated as an important determinant of the reduced response to the spermine analogue N1,N12-bis(ethyl)spermine (BESpm) by the cisplatin or cis-diamminedichloroplatinum(II) (cDDP)- resistant human ovarian carcinoma cell line (C13*). We checked whether or not under conditions of SSAT...

Natural categories: Well defined or fuzzy sets?

Thirty college students made category membership decisions for each of 540 candidate exemplar-category name pairs (e.g.,apple-fruit) in each of two separate sessions. For highly typical category members (e.g., chair for thefurniture category), and for items unrelated to a category (e.g.,cucumber-furniture), subjects agreed with each other and were consistent in their decisions...