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The US FRAX® filter: avoiding confusion or hindering progress?

I don’t do quagmiresDonald RumsfeldUS Department of Defence News Briefing, July 2003“The leadership of NOF and ISCD has decided after long and careful consideration that a FRAX® filter should be available, and this will happen in the USA.” So speak the proponents of the US FRAX® filter. Unfortunately, the careful consideration appears to have been driven more by threat than ...

S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion

Neoplastic growth is associated with increased polyamine biosynthetic activity and content. Tumor promoter treatment induces the rate-limiting enzymes in polyamine biosynthesis, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC), and targeted ODC overexpression is sufficient for tumor promotion in initiated mouse skin. We generated a mouse model with ...

FRAX™ and the assessment of fracture probability in men and women from the UK

Bone Diseases, University of Sheffield Medical School , Beech Hill Road, Sheffield S10 2RX, UK 2 E. McCloskey Osteoporosis Centre, Northern General Hospital , Sheffield, UK Summary A fracture risk

‘Sink or swim’: an evaluation of the clinical characteristics of individuals with high bone mass

Summary High bone mineral density on routine dual energy X-ray absorptiometry (DXA) may indicate an underlying skeletal dysplasia. Two hundred fifty-eight individuals with unexplained high bone mass (HBM), 236 relatives (41% with HBM) and 58 spouses were studied. Cases could not float, had mandible enlargement, extra bone, broad frames, larger shoe sizes and increased body mass ...

Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin

The limited induction of spermidine/spermine N1- acetyltransferase (SSAT) activity has been implicated as an important determinant of the reduced response to the spermine analogue N1,N12-bis(ethyl)spermine (BESpm) by the cisplatin or cis-diamminedichloroplatinum(II) (cDDP)- resistant human ovarian carcinoma cell line (C13*). We checked whether or not under conditions of SSAT ...

Natural categories: Well defined or fuzzy sets?

Thirty college students made category membership decisions for each of 540 candidate exemplar-category name pairs (e.g.,apple-fruit) in each of two separate sessions. For highly typical category members (e.g., chair for thefurniture category), and for items unrelated to a category (e.g.,cucumber-furniture), subjects agreed with each other and were consistent in their decisions. ...