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Search: authors:"E. P. Araújo"

4 papers found.
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Short-term inhibition of peroxisome proliferator-activated receptor-γ coactivator-1α expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice

Aims/hypothesis The coactivator of nuclear receptors, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has been implicated in a series of events that contribute to the control of glucose metabolism. We have recently reported the use of a PGC-1α antisense oligonucleotide (PGC-1αAS) that inhibits up to 60% of PGC-1α expression in pancreatic islets, leading to...

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats

Aim/hypothesis By acting in the brain, insulin suppresses food intake. However, little is known with regard to insulin signalling in the hypothalamus in insulin-resistant states. Methods Western blotting, immunohistochemistry and polymerase chain reaction assays were combined to compare in vivo hypothalamic insulin signalling through the PI3-kinase and MAP kinase pathways between...

Peroxisome proliferator-activated receptor γ coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion

Aims/hypothesis Sympathetic inputs inhibit insulin secretion through α2-adrenergic receptors coupled with Gi protein. High adrenergic tonus generated by exposure of homeothermic animals to cold reduces insulin secretion. In this study we evaluate the participation of UCP-2 in cold-induced regulation of insulin secretion. Methods Static insulin secretion studies, western blotting...