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Modern work-up and extended resection in perihilar cholangiocarcinoma: the AMC experience

. They are sub-classified according to their location, in intrahepatic, perihilar and distal cholangiocarcinoma [2]. Each entity comes with F. Rassam and E. Roos contributed equally to this work ... , acquisition of data, analysis and interpretation of data, drafting of manuscript. E. Roos: study conception and design, acquisition of data, analysis and interpretation of data, drafting of manuscript. K.P. van

Motor control strategies during double leg squat following anterior cruciate ligament rupture and reconstruction: an observational study

Background Anterior cruciate ligament (ACL) injured individuals often show asymmetries between the injured and non-injured leg. A better understanding of the underlying motor control could help to improve rehabilitation. Double leg squat exercises allow for compensation strategies. This study therefore investigated motor control strategies during a double leg squat with the aim...

A quantitative account of genomic island acquisitions in prokaryotes

Background Microbial genomes do not merely evolve through the slow accumulation of mutations, but also, and often more dramatically, by taking up new DNA in a process called horizontal gene transfer. These innovation leaps in the acquisition of new traits can take place via the introgression of single genes, but also through the acquisition of large gene clusters, which are...

Optimal Dose Levels in Screening Chest CT for Unimpaired Detection and Volumetry of Lung Nodules, with and without Computer Assisted Detection at Minimal Patient Radiation

Objectives The aim of this phantom study was to minimize the radiation dose by finding the best combination of low tube current and low voltage that would result in accurate volume measurements when compared to standard CT imaging without significantly decreasing the sensitivity of detecting lung nodules both with and without the assistance of CAD. Methods An anthropomorphic...

Effect of tubulin-binding agents on the infiltration of tumour cells into primary hepatocyte cultures

interaction with MB6A cells (O. P. Middelkoop & E. Roos, 244 unpublished data). We found that Fab fragments prepared from antisera against sinusoidal surface-enriched, and against contiguous surface-enriched