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Short-term high glucose culture potentiates pancreatic beta cell function

AbdulkaderOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University, Oxford, United KingdomPatrik Rorsman AuthorsSearch for Eduardo Rebelato in:Nature Research journals • PubMed • Google Scholar ... authors declare no competing interests. Corresponding author Correspondence to Eduardo Rebelato. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0

Control of the Intracellular Redox State by Glucose Participates in the Insulin Secretion Mechanism

Background Production of reactive oxygen species (ROS) due to chronic exposure to glucose has been associated with impaired beta cell function and diabetes. However, physiologically, beta cells are well equipped to deal with episodic glucose loads, to which they respond with a fine tuned glucose-stimulated insulin secretion (GSIS). In the present study, a systematic investigation...