Most studies that have evaluated the association between anti-diabetic medication and cancer risk have suffered from methodological drawbacks. To avoid time-related biases, we evaluated the effect of treatment duration on the cancer risk among naive users of anti-diabetic medication as compared to non-users. In addition, we addressed the influence of common risk factors such as ...
A diet with restricted energy content reduces the occurrence of cancer in animal experiments. It is not known if the underlying mechanism also exists in human beings. To determine whether cancer incidence is reduced among patients with anorexia nervosa who tend to have a low intake of energy, we carried out a retrospective cohort study of 22 654 women and 1678 men diagnosed with ...
This paper reviews the use of the Finnish Information System on Occupational Exposure (Finnish job-exposure matrix, FINJEM) in different applications in Finland and other countries. We describe and discuss studies on FINJEM and studies utilizing FINJEM in regard to the validity of exposure estimates, occupational epidemiology, hazard surveillance and prevention, the assessment of ...
Recent studies have suggested that statins, an established drug group in the prevention of cardiovascular mortality, could delay or prevent breast cancer recurrence but the effect on disease-specific mortality remains unclear. We evaluated risk of breast cancer death among statin users in a population-based cohort of breast cancer patients. The study cohort included all newly ...
Increased incidence of skin cancers among airline cabin crew has been reported in several studies. We evaluated whether the difference in risk factor prevalence between Finnish airline cabin crew and the general population could explain the increased incidence of skin cancers among cabin crew, and the possible contribution of estimated occupational cosmic radiation exposure. A ...
, Eero Pukkala); Women's Hospital, Helsinki University Hospital , Helsinki, Finland (Heli Lyytinen , Olavi Ylikorkala); and Finnish Cancer Registry, Institute of Statistical and Epidemiological Cancer ... Research , Helsinki , Finland ( Eero Pukkala). This work was supported by the Finnish Cancer Research Foundation. Conflict of interest: none declared American Journal of Epidemiology The Author 2012
. Eriksson 4 5 Harri Rissanen 6 Paul Knekt 6 Eero Pukkala 8 9 Pekka Jousilahti 6 Veikko Salomaa 6 Samuli Ripatti 7 Aarno Palotie 7 Heikki Ja€rvinen Laura Renkonen-Sinisalo Anna Lepisto¨ Jan Bo¨ hm Jukka-Pekka
Weiderpass and Eero Pukkala. EP provided the materials and performed the statistical analysis of the data, helped with the interpretation of results, and commented the manuscript. EW interpreted the data ... studies as decreasing risk for colon cancer, was higher among wealthier women in Finland up to 1980s [ 87 ], and the social class differences in use of these drugs disappeared in the 1990s (Dr. Eero
Background A substantial number of epidemiologic studies have provided estimates of the relation between exposure to benzene at work and the risk of leukemia, but the results have been heterogeneous. To bridge this gap in knowledge, we synthesized the existing epidemiologic evidence on the relation between occupational exposure to benzene and the risk of leukemia, including all ...
Background Trichloroethylene (TCE) is a widely used chlorinated solvent with demonstrated carcinogenicity in animal assays. Some epidemiologic studies have reported increased risk of cancer of the kidney, cervix, liver and biliary passages, non-Hodgkin lymphoma, and esophageal adenocarcinoma.
Aims/hypothesis The evidence on the association between pioglitazone use and bladder cancer is contradictory, with many studies subject to allocation bias. The aim of our study was to examine the effect of exposure to pioglitazone on bladder cancer risk internationally across several cohorts. The potential for allocation bias was minimised by focusing on the cumulative effect of ...
Background Breast cancer incidence continuous to increase. We examined at population level the association between the relative excess risk of breast cancer and previous age of mother at first birth. Method Incidence of breast cancer in 34 industrialized countries was obtained from the GLOBOCAN 2002 and SEER databases. Data on age of mother at first birth was collected through ...
Many cancer predisposition syndromes are rare or have incomplete penetrance, and traditional epidemiological tools are not well suited for their detection. Here we have used an approach that employs the entire population based data in the Finnish Cancer Registry (FCR) for analyzing familial aggregation of all types of cancer, in order to find evidence for previously unrecognized ...
Background Control of reproduction and prevention of reproductive health problems are important reasons for women to use health services, but the proper organisational level of service provision is not clear. The purpose of this study was to investigate whether visits to private gynaecologists correlate with better health outcomes and worse participation in organised screening for ...
Background. The risk factors for Merkel cell carcinoma (MCC), a rare type of skin cancer, are poorly understood. Some evidence suggests that MCC is more common in individuals with abnormal immune function resulting from viral infection, autoimmune disease or organ trans- plantation. Methods. The national Renal Transplant Registry and the Finnish Cancer Registry data were searched ...
Knowledge is limited on mortality of grand multiparous women (≥5 deliveries), whose hormonal, metabolic, and social conditions differ from the average. The authors studied overall and cause-specific mortality in 1974–2001 among 87,922 grand multiparous women including 3,678 grand grand multiparous women (≥10 deliveries) in Finland. Standardized mortality ratios were defined as ...
Epidemiological Cancer Research, Helsinki, Finland (Eero Pukkala); School of Public Health, University of Tampere, Tampere, Finland (Eero Pukkala); Department of Mental Health and Substance Abuse Services, National
Objectives: The objective of this study was to evaluate the performance and effectiveness of a register of employees exposed to carcinogens (the ASA Register) which has been in operation in Finland since 1979, and to study cancer risks among the notified workers. Methods: The impact of ASA at workplaces was studied by questionnaires mailed to 1448 work departments, which were ...
Few studies have suggested that elevated blood pressure might be associated with increased risk of lung cancer and that this association might vary according to smoking status. The aim of this study was to assess the effect of blood pressure and its possible interaction with smoking on lung cancer incidence in hypertensive patients. Lung cancer incidence was determined for 7,908 ...
Background The aim of this study was first, to investigate whether women starting oral contraceptive (OC) use at a young age and before first birth have an increased risk for breast cancer and second, to report difficulties encountered in studying long-term health impacts of medical technologies. Methods Breast cancers occurring up until 1997 among 37153 Helsinki students born ...