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39 papers found.
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Incidence of sexually transmitted infections during pregnancy

. Teasdale, Elaine J. Abrams, Mary Ann Chiasson, Kelly Blanchard, Heidi E. Jones. Data curation: Chloe A. Teasdale, Kelly Blanchard. Formal analysis: Chloe A. Teasdale. Methodology: Chloe A. Teasdale, Mary ... Ann Chiasson, Jessica Justman, Kelly Blanchard, Heidi E. Jones. Project administration: Kelly Blanchard. Supervision: Elaine J. Abrams, Heidi E. Jones. Validation: Chloe A. Teasdale. Writing

Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children

, Ashraf Coovadia, Elaine J. Abrams, Caroline T. Tiemessen. Methodology: Maria Paximadis, Bianca Da Costa Dias, Shayne Loubser, Renate Strehlau, Faeezah Patel, Stephanie Shiau, Elaine J. Abrams, Caroline T ... , Ashraf Coovadia, Elaine J. Abrams. 12 / 14 J Infect Dis. 2013; 208(8):1202±11. Epub 2013/07/16. https://doi.org/10.1093/infdis/jit311 PMID: 23852127 13 / 14 1. Ananworanich J , Chomont N , Eller LA

Burnout and self-reported suboptimal patient care amongst health care workers providing HIV care in Malawi

) Acknowledgments Disclaimer Government. Author Contributions Nyasulu, Elaine J. Abrams. Conceptualization: Maria H. Kim, Alick C. Mazenga, Katie Simon, Saeed Ahmed, Phoebe We thank the Malawi Ministry of Health ... . Mazenga, Katie Simon. Writing ± original draft: Maria H. Kim, Alick C. Mazenga, Xiaoying Yu, Elaine J. Abrams. Writing ± review & editing: Maria H. Kim, Alick C. Mazenga, Katie Simon, Xiaoying Yu, Saeed

Decline in CD4 T lymphocytes with monotherapy bridging strategy for non-adherent adolescents living with HIV infection: Results of the IMPAACT P1094 randomized trial

Introduction Management of persistently non-adherent youth living with HIV (YLHIV) with virologic failure (VF) on combination antiretroviral therapy (cART) remains challenging. One strategy has been using 3TC/ FTC monotherapy (3TC/FTC), which in the presence of the M184V resistance mutation, does not suppress viral replication nor select for additional drug resistance mutations...

Self-Reported Side Effects and Adherence to Antiretroviral Therapy in HIV-Infected Pregnant Women under Option B+: A Prospective Study

Background Antiretroviral therapy (ART) regimens containing efavirenz (EFV) are recommended as part of universal ART for pregnant and breastfeeding women. EFV may have appreciable side effects (SE), and ART adherence in pregnancy is a major concern, but little is known about ART SE and associations with adherence in pregnancy. Methods We investigated the distribution of patient...

Risk factors for loss to follow-up prior to ART initiation among patients enrolling in HIV care with CD4+ cell count ≥200 cells/μL in the multi-country MTCT-Plus Initiative

Background In resource-limited settings, many HIV-infected patients are lost to follow-up (LTF) before starting ART; risk factors among those not eligible for ART at enrollment into care are not well described. Methods We examined data from 4,278 adults (3,613 women, 665 men) enrolled in HIV care through March 2007 in the MTCT-Plus Initiative with a CD4 count ≥200 cells/mm 3 and...

Clinical Impact and Cost-effectiveness of Diagnosing HIV Infection During Early Infancy in South Africa: Test Timing and Frequency

Background. Diagnosis of human immunodeficiency virus (HIV) infection during early infancy (commonly known as “early infant HIV diagnosis” [EID]) followed by prompt initiation of antiretroviral therapy dramatically reduces mortality. EID testing is recommended at 6 weeks of age, but many infant infections are missed. Design/Methods. We simulated 4 EID testing strategies for HIV...

Why Did I Stop? Barriers and Facilitators to Uptake and Adherence to ART in Option B+ HIV Care in Lilongwe, Malawi

Causes for loss-to-follow-up, including early refusals of and stopping antiretroviral therapy (ART), in Malawi’s Option B+ program are poorly understood. This study examines the main barriers and facilitators to uptake and adherence to ART under Option B+. In depth interviews were conducted with HIV-infected women who were pregnant or postpartum in Lilongwe, Malawi (N = 65...

Characteristics and outcomes of adult Ethiopian patients enrolled in HIV care and treatment: a multi-clinic observational study

Background We describe trends in characteristics and outcomes among adults initiating HIV care and treatment in Ethiopia from 2006-2011. Methods We conducted a retrospective longitudinal analysis of HIV-positive adults (≥15 years) enrolling at 56 Ethiopian health facilities from 2006–2011. We investigated trends over time in the proportion enrolling through provider-initiated...

Impact of Antiretroviral Drugs in Pregnant Women and Their Children in Africa: HIV Resistance and Treatment Outcomes

The global community has committed itself to eliminating new pediatric HIV infections by 2015 and improving maternal, newborn, and child health and survival in the context of HIV. Such objectives require regimens to prevent mother-to-child transmission (pMTCT) which, while being highly efficacious, protect the efficacy of future first-line antiretroviral therapy (ART). Major...

Adapting Evidence-Based Interventions to Meet the Needs of Adolescents Growing Up with HIV in South Africa: The VUKA Case Example

The VUKA family program is one of the only evidence-based interventions to promote positive psychosocial outcomes in South African HIV-infected pre- and early adolescents and their families. In this paper, we discuss the collaborative process by which a multidisciplinary team of clinicians, researchers, counselors, and artists/educators and families adapted and developed VUKA for...

Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment

Background While studies of HIV-infected adults on antiretroviral treatment (ART) report no sex differences in immune recovery and virologic response but more ART-associated complications in women, sex differences in disease progression and response to ART among children have not been well assessed. The objective of this study was to evaluate for sex differences in response to...

Reviewing progress: 7 year trends in characteristics of adults and children enrolled at HIV care and treatment clinics in the United Republic of Tanzania

Background To evaluate the on-going scale-up of HIV programs, we assessed trends in patient characteristics at enrolment and ART initiation over 7 years of implementation. Methods Data were from Optimal Models, a prospective open cohort study of HIV-infected (HIV+) adults (≥15 years) and children (<15 years) enrolled from January 2005 to December 2011 at 44 HIV clinics in 3...

Gestational Diabetes Mellitus in HIV-Infected and -Uninfected Pregnant Women in Cameroon

MARCIA WONG, MD, MPH2 RUSSELL B. VAN DYKE, MD3 MITCHELL GEFFNER, MD4 EMMANUEL NSHOM, MSC5 DENNIS PALMER, MD5 PIUS T. MUFFIH, PHD5 ELAINE J. ABRAMS, MD6 RHODA S. SPERLING, MD7 DEREK LEROITH, MD, PHD8

Maternal CD4+ Cell Count Decline after Interruption of Antiretroviral Prophylaxis for the Prevention of Mother-to-Child Transmission of HIV

Background We evaluated maternal CD4+ cell count (CD4+) decline after PMTCT prophylaxis in a multi-country HIV care program. Methods Analysis was restricted to antiretroviral therapy (ART)-naive, HIV-infected pregnant women with CD4+ ≥250 cells/mm3 at enrollment. Single-dose nevirapine (sd-NVP) or short-course antiretroviral prophylaxis (sc-ARVp) with zidovudine (AZT) or AZT...

Treatment of Young Children with HIV Infection: Using Evidence to Inform Policymakers

Andrew Prendergast and colleagues consider the evidence for a change in policy for the treatment of young children infected with HIV.

Determinants of Mortality and Loss to Follow-Up among Adults Enrolled in HIV Care Services in Rwanda

Background Antiretroviral therapy (ART) improves morbidity and mortality in patients with HIV, however high rates of loss to follow-up (LTF) and mortality have been documented in HIV care and treatment programs. Methods We analyzed routinely-collected data on HIV-infected patients ≥15 years enrolled at 41 healthcare facilities in Rwanda from 2005 to 2010. LTF was defined as not...

Impact of Antiretroviral Therapy on Incidence of Pregnancy among HIV-Infected Women in Sub-Saharan Africa: A Cohort Study

A multicountry cohort study in sub-Saharan Africa by Landon Myer and colleagues reveals higher pregnancy rates in HIV-infected women on antiretroviral therapy (ART).

Low Rates of Mother-to-Child HIV Transmission in a Routine Programmatic Setting in Lilongwe, Malawi

Background The Tingathe program utilizes community health workers to improve prevention of mother-to-child transmission (PMTCT) service delivery. We evaluated the impact of antiretroviral (ARV) regimen and maternal CD4+ count on HIV transmission within the Tingathe program in Lilongwe, Malawi. Methods We reviewed clinical records of 1088 mother-infant pairs enrolled from March...

Adherence and virologic suppression during the first 24 weeks on antiretroviral therapy among women in Johannesburg, South Africa - a prospective cohort study

Mia Ekstrom Ashraf Coovadia Elaine J Abrams Max Petzold 0 David Katzenstein Lynn Morris Louise Kuhn 0 Nordic School of Public Health (NHV) , Gothenburg , Sweden Background: Adherence is a necessary