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Choosing Important Health Outcomes for Comparative Effectiveness Research: An Updated Review and Identification of Gaps

Background The COMET (Core Outcome Measures in Effectiveness Trials) Initiative promotes the development and application of core outcome sets (COS), including relevant studies in an online database. In order to keep the database current, an annual search of the literature is undertaken. This study aimed to update a previous systematic review, in order to identify any further ...

The COMET initiative database: progress and activities update (2014)

The COMET Initiative database is a repository of studies relevant to the development of core outcome sets (COS). Use of the website continues to increase, with more than 16,500 visits in 2014 (36 % increase over 2013), 12,257 unique visitors (47 % increase), 9780 new visitors (43 % increase) and a rise in the proportion of visits from outside the UK (8565 visits; 51 % of all ...

Collating the knowledge base for core outcome set development: developing and appraising the search strategy for a systematic review

Background The COMET (Core Outcome Measures in Effectiveness Trials) Initiative is developing a publicly accessible online resource to collate the knowledge base for core outcome set development (COS) and the applied work from different health conditions. Ensuring that the database is as comprehensive as possible and keeping it up to date are key to its value for users. This ...

Choosing Important Health Outcomes for Comparative Effectiveness Research: An Updated Review and User Survey

Background A COS represents an agreed minimum set of outcomes that should be measured and reported in all trials of a specific condition. The COMET (Core Outcome Measures in Effectiveness Trials) initiative aims to collate and stimulate the development and application of COS, by including data on relevant studies within a publically available internet-based resource. In recent ...

Towards core outcome set (COS) development: a follow-up descriptive survey of outcomes in Cochrane reviews

Paula Williamson 4 Elizabeth Gargon 4 0 School of Nursing & Midwifery, Trinity College Dublin , 24 D'Olier Street, Dublin 2 , Ireland 1 All-Ireland Hub for Trials Methodology Research, Queens University

COS-STAR: a reporting guideline for studies developing core outcome sets (protocol)

Trials Methodology Research (HTMR)), Mike Clarke (Director of the MRC All-Ireland HTMR) and Elizabeth Gargon (Project Coordinator for the COMET Initiative) form the COMET Management Group (COMET MG). For

The COMET Initiative database: progress and activities from 2011 to 2013

The Core Outcome Measures in Effectiveness Trials (COMET) Initiative database is an international repository of studies relevant to the development of core outcome sets. By the end of 2013, it included a unique collection of 306 studies. The website is increasingly being used, with more than 12,000 visits in 2013 (a 55% increase over 2012), 8,369 unique visitors (a 53% increase) ...

Can a core outcome set improve the quality of systematic reviews? – a survey of the Co-ordinating Editors of Cochrane review groups

Background Missing outcome data or the inconsistent reporting of outcome data in clinical research can affect the quality of evidence within a systematic review. A potential solution is an agreed standardized set of outcomes known as a core outcome set (COS) to be measured in all studies for a specific condition. We investigated the amount of missing patient data for primary ...

Choosing Important Health Outcomes for Comparative Effectiveness Research: A Systematic Review

Background A core outcome set (COS) is a standardised set of outcomes which should be measured and reported, as a minimum, in all effectiveness trials for a specific health area. This will allow results of studies to be compared, contrasted and combined as appropriate, as well as ensuring that all trials contribute usable information. The COMET (Core Outcome Measures for ...

Adverse Drug Reactions in Children—A Systematic Review

Background Adverse drug reactions in children are an important public health problem. We have undertaken a systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community. We were particularly interested in understanding how ADRs might be better detected, assessed and avoided. ...

Developing core outcome sets for clinical trials: issues to consider

Paula R Williamson 0 Douglas G Altman Jane M Blazeby Mike Clarke Declan Devane Elizabeth Gargon 0 Peter Tugwell 0 Department of Biostatistics, University of Liverpool , Shelley's Cottage, Brownlow

Using qualitative methods to inform the trade-off between content validity and consistency in utility assessment: the example of type 2 diabetes and Alzheimer's Disease

publicly traded or in a publicly traded company. Furthermore, she is not a member of an advisory board or board of directors. Elizabeth Gargon worked as a Research Associate at Mapi Values. She provided ... support to Diana Rofail on this project in terms of the presentation and interpretation of results. Elizabeth Gargon does not have ownerships intents (including stock options) in a start up company, the