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Sources of error in measurement of minimal residual disease in childhood acute lymphoblastic leukemia

acquisition: Alexander Morley. Investigation: Sue Latham, Elizabeth Hughes, Bradley Budgen, Catherine Crock. Methodology: Sue Latham, Elizabeth Hughes, Bradley Budgen, Catherine Crock. Project administration ... Latham, Elizabeth Hughes, Bradley Budgen, Francoise Mechinaud, Catherine Crock, Henry Ekert, Peter Campbell. 9 / 10 1. Brisco MJ , Condon J , Hughes E , Neoh SH , Sykes PJ , Seshadri R et al. Outcome

Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism

Autism spectrum disorder (hereafter referred to as “ASD”) is a heterogeneous neurodevelopmental condition characterized by impaired social communication and interactions, and restricted, repetitive activities or interests. Alterations in network connectivity and memory function are frequently observed in autism patients, often involving the hippocampus. However, specific changes ...

Future enhanced clinical role of pharmacists in Emergency Departments in England: multi-site observational evaluation

Background There are concerns about maintaining appropriate clinical staffing levels in Emergency Departments. Pharmacists may be one possible solution. Objective To determine if Emergency Department attendees could be clinically managed by pharmacists with or without advanced clinical practice training. Setting Prospective 49 site cross-sectional observational study of patients ...

Disentangling psychopathology, substance use and dependence: a factor analysis

Background The notion that substance use can induce symptoms of depression and anxiety is influential in clinical practice, however questions remain about the empirical support for this hypothesis. Methods We analysed mental health and substance dependence screening records for 280 outpatients in addictions treatment. Item-level data for depression (PHQ-9), anxiety (GAD-7), ...

The prevalence of novel psychoactive substances (NPS) use in non-clinical populations: a systematic review protocol

Background Novel psychoactive substances (NPS) are new narcotic or psychotropic drugs that are not controlled by the United Nations drug convention that may pose a serious public health threat due to their wide availability for purchase on the internet and in so called “head shops.” Yet, the extent of their global use remains largely unknown. The aim of this study is to conduct a ...

A Systematic Review and Meta-analysis of Psychosocial Interventions to Reduce Drug and Sexual Blood Borne Virus Risk Behaviours Among People Who Inject Drugs

Opiate substitution treatment and needle exchanges have reduced blood borne virus (BBV) transmission among people who inject drugs (PWID). Psychosocial interventions could further prevent BBV. A systematic review and meta-analysis examined whether psychosocial interventions (e.g. CBT, skills training) compared to control interventions reduced BBV risk behaviours among PWID. 32 and ...

Perceptions and Impact of Mandatory eLearning for Foundation Trainee Doctors: A Qualitative Evaluation

Background Junior doctors in the UK must complete various educational components during their two year Foundation training programme. It is important that mandatory learning is informative and engaging. The aim of this study was to evaluate trainee doctors’ perceptions of a Technology Enhanced Learning (TEL) programme developed to improve prescribing competency. Method Focus groups ...

An evaluation of UK foundation trainee doctors’ learning behaviours in a technology-enhanced learning environment

Background Technology-Enhanced Learning (TEL) can be used to educate Foundation Programme trainee (F1 and F2) doctors. Despite the advantages of TEL, learning behaviours may be exhibited that are not desired by system developers or educators. The aim of this evaluation was to investigate how learner behaviours (e.g. time spent on task) were affected by temporal (e.g. time of year), ...

A new tool to evaluate postgraduate training posts: the Job Evaluation Survey Tool (JEST)

Programme Director for Health Education West Midlands, UK. Elizabeth Hughes BSc MB ChB, FRCP, is postgraduate medical dean at Health Education West Midlands and professor in chemical pathology at Sandwell and

Training in dual diagnosis interventions (the COMO Study): Randomised controlled trial

Background Despite the high prevalence of co-morbid substance use among mental health service users (dual diagnosis), very few mental health workers in the UK have had training and/or clinical experience to equip them to deliver targeted interventions to this client group. Method In a randomised controlled trial of training for dual diagnosis interventions, 79 case managers from 12 ...