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Search: authors:"Ellen V. Rothenberg"

9 papers found.
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Spontaneous Expression of Interleukin-2 In Vivo in Specific Tissues of Young Mice

In situ hybridization and immunohistochemistry were used to determine the spectrum of tissues in which interleukin-2 (IL-2) mRNA and protein are found in healthy, normal young mice. In neonatal animals, IL-2 is expressed specifically by distinct, isolated cells at three major sites: the thymus, skin, and gut. Based on morphology and distribution, the IL-2-expressing cells...

Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture

Background/Objectives A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage. We elucidate how the gene/protein dynamics for a core transcriptional module governs this important process by computational...

Epigenetic mechanisms and developmental choice hierarchies in T-lymphocyte development

Three interlocking problems in gene regulation are: how to explain genome-wide targeting of transcription factors in different cell types, how prior transcription factor action can establish an ‘epigenetic state’ that changes the options for future transcription factor action, and how directly a sequence of developmental decisions can be memorialized in a hierarchy of repression...

Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3

Marissa Morales Del Real 0 Ellen V. Rothenberg 0 0 Division of Biology 156-29, California Institute of Technology , Pasadena, CA 91125 , USA SUMMARY Hematopoiesis is a classic system with which to

Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence

Erica Manesso Vijay Chickarmane Hao Yuan Kueh Ellen V. Rothenberg Carsten Peterson 0 Division of Biology, California Institute of Technology , Pasadena, CA, USA 1 Computational Biology and Biological

Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells

Satoko Adachi 0 Ellen V. Rothenberg 0 0 Division of Biology 156-29, California Institute of Technology , Pasadena, CA 91125, USA T-cells retain cell-type-specific programming for IL-2 inducibility

Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints

A central question in T cell development is what makes cortical thymocytes respond to stimulation in a qualitatively different way than any other thymocyte subset. Part of the answer is that AP-1 function changes drastically at two stages of T cell development. It undergoes striking down-regulation as thymocytes differentiate from immature, CD4–CD8– double-negative (DN) TCR...

Chromatin remodeling of the interleukin-2 gene: Distinct alterations in the proximal versus distal enhancer regions

Known transcription factor-DNA interactions in the minimal enhancer of the murine interleukin-2 gene (IL-2) do not easily explain the T cell specificity of IL-2 regulation. To seek additional determinants of cell type specificity, in vivo methodologies were employed to examine chromatin structure 5′ and 3′ of the 300 bp IL-2 proximal promoter/enhancer region. Restriction enzyme...

Complex expression patterns of lymphocyte-specific genes during the development of cartilaginous fish implicate unique lymphoid tissues in generating an immune repertoire

Cartilaginous fish express canonical B and T cell recognition genes, but their lymphoid organs and lymphocyte development have been poorly defined. Here, the expression of Ig, TCR, recombination-activating gene (Rag)-1 and terminal deoxynucleosidase (TdT) genes has been used to identify roles of various lymphoid tissues throughout development in the cartilaginous fish, Raja...