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Search: authors:"Emilie Schindler"

3 papers found.
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A Minimal Continuous-Time Markov Pharmacometric Model

In this work, an alternative model to discrete-time Markov model (DTMM) or standard continuous-time Markov model (CTMM) for analyzing ordered categorical data with Markov properties is presented: the minimal CTMM (mCTMM). Through a CTMM reparameterization and under the assumption that the transition rate between two consecutive states is independent on the state, the Markov...

A pharmacokinetic binding model for bevacizumab and VEGF165 in colorectal cancer patients

Purpose To characterize the population pharmacokinetics of bevacizumab, its binding properties to VEGF165 and the effect of demographic data and VEGF-A polymorphisms on the interplay between bevacizumab serum pharmacokinetics and VEGF165 serum concentrations in patients with colorectal cancer stage IV. Methods Bevacizumab and VEGF165 data were collected from 19 adult patients...