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13 papers found.
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A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR ...

Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae

Background Eukaryotic genomes are replicated during S phase according to a temporal program. Several determinants control the timing of origin firing, including the chromatin environment and epigenetic modifications. However, how chromatin structure influences the timing of the activation of specific origins is still poorly understood. Results By performing high-resolution analysis ...

Letter to the Editor regarding “Lactose does not interfere with the analysis of sialic acids as their 1,2-diamino-4,5-methylenedioxybenzene derivatives”

Dear Sir,Recently, Spichtig et al. [1] published in this journal a Technical Note regarding the analysis of sialic acids from infant formulas using 1,2-diamino-4,5-methylenedioxybenzene derivatives, a method previously proposed by us in 2007 [2]. In this Technical Note, Spichtig et al. stated that lactose does not interfere with the analysis, conversely to what we hypothesized in ...

Gravity or turbulence? – II. Evolving column density probability distribution functions in molecular clouds

It has been recently shown that molecular clouds do not exhibit a unique shape for the column density probability distribution function (N-PDF). Instead, clouds without star formation seem to possess a lognormal distribution, while clouds with active star formation develop a power-law tail at high column densities. The lognormal behaviour of the N-PDF has been interpreted in terms ...

Molecular cloud evolution – IV. Magnetic fields, ambipolar diffusion and the star formation efficiency

We investigate the formation and evolution of giant molecular clouds (GMCs) by the collision of convergent warm neutral medium (WNM) streams in the interstellar medium, in the presence of magnetic fields and ambipolar diffusion (AD), focusing on the evolution of the star formation rate and efficiency (SFE), as well as of the mass-to-magnetic-flux ratio (M2FR) in the forming clouds. ...

Gravity or turbulence? Velocity dispersion–size relation

We discuss the nature of the velocity dispersion versus size relation for molecular clouds. In particular, we add to previous observational results showing that the velocity dispersions in molecular clouds and cores are not purely functions of the spatial scale but involve surface gas densities as well. We emphasize that hydrodynamic turbulence is required to produce the first ...

Dependence of the star formation efficiency on global parameters of molecular clouds

We investigate the response of the star formation efficiency (SFE) to the main parameters of simulations of molecular cloud formation and evolution (growth and star formation) by the collision of warm diffuse medium [warm neutral medium (WNM)] cylindrical streams, and compare our results with theoretical predictions for this dependence. The parameters we vary are the Mach number of ...

On the gravitational content of molecular clouds and their cores

The gravitational term for clouds and cores entering in the virial theorem is usually assumed to be equal to the gravitational energy, since the contribution to the gravitational force from the mass distribution outside the volume of integration is assumed to be negligible. Such approximation may not be valid in the presence of an important external net potential. In the present ...

A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis

Background Non-hereditary colorectal cancer (CRC) is a complex disorder resulting from the combination of genetic and non-genetic factors. Genome–wide association studies (GWAS) are useful for identifying such genetic susceptibility factors. However, the single loci so far associated with CRC only represent a fraction of the genetic risk for CRC development in the general ...

The nature of the velocity field in molecular clouds – I. The non-magnetic case

We present numerical simulations designed to test some of the hypotheses and predictions of recent models of star formation. We consider a set of three numerical simulations of randomly driven, isothermal, non-magnetic, self-gravitating turbulence with different rms Mach numbers Ms and physical sizes L, but with approximately the same value of the virial parameter, α≈ 1.2. We ...

Genetic Structure of the Spanish Population

Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have ...

The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease

Background In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population. Methods We genotyped 1,128 individuals using the Affymetrix Nsp I 250K chip. A sample of 327 sporadic AD patients and 801 controls with unknown cognitive status from the Spanish general population were included in our ...