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Non-invasive vagus nerve stimulation for treatment of cluster headache: early UK clinical experience

Evidence supports the use of non-invasive vagus nerve stimulation (nVNS; gammaCore®) as a promising therapeutic option for patients with cluster headache (CH). We conducted this audit of real-world data from patients with CH, the majority of whom were treatment refractory, to explore early UK clinical experience with nVNS used acutely, preventively, or both. We retrospectively...

Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study

Background In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric...

Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study

In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes...

Consistent effects of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: additional findings from the randomized, sham-controlled, double-blind PRESTO trial

); Gabriella Egeo, MD, PhD (Subinvestigator); Luisa Fofi, MD (Subinvestigator). electroCore Study Team: Eric Liebler (Senior Vice President, Neurology); Annelie Andersson (Senior Director, Clinical Director

Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial

, PhD (Subinvestigator); Luisa Fofi, MD (Subinvestigator). electroCore Study Team: Eric Liebler (Senior Vice President, Neurology); Annelie Andersson (Senior Director, Clinical Director); Lia Spitzer ... Grazzi, MD, Cristina Tassorelli, MD, PhD, and Eric Liebler contributed to the PRESTO study design and provided detailed input into the development of the manuscript. All primary investigators were involved

Non-invasive Vagus Nerve Stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study

Background Menstrual migraine and menstrually related migraine attacks are typically longer, more disabling, and less responsive to medications than non-menstrual attacks. The aim of this study was to evaluate the efficacy, safety, and tolerability of non-invasive vagus nerve stimulation for the prophylactic treatment of menstrual migraine/menstrually related migraine. Methods...

Non-invasive Vagus Nerve Stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study

Menstrual migraine and menstrually related migraine attacks are typically longer, more disabling, and less responsive to medications than non-menstrual attacks. The aim of this study was to evaluate the efficacy, safety, and tolerability of non-invasive vagus nerve stimulation for the prophylactic treatment of menstrual migraine/menstrually related migraine. Fifty-six enrolled...

Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study

electroCore. Eric Liebler is an employee of electroCore. Dr. Gabriella Egeo, Dr. Gennaro Bussone, and Ms. Anna Maria Padovan have no competing interests to declare. Authors’ contributions PB and LG developed

Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study

electroCore. Dr. Licia Grazzi has also served as a consultant and scientific advisor for Allergan and electroCore. Eric Liebler is an employee of electroCore. Dr. Gabriella Egeo, Dr. Gennaro Bussone, and Ms

Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial

(Principal Investigator); Cinzia Aurilia, MD (Subinvestigator); Gabriella Egeo, MD, PhD (Subinvestigator); Luisa Fofi, MD (Subinvestigator). electroCore Study Team: Eric Liebler (Senior Vice President ... participant data will not be shared. Authors’ contributions Licia Grazzi, MD, Cristina Tassorelli, MD, PhD, and Eric Liebler contributed to the PRESTO study design and provided detailed input into the

Cost-effectiveness analysis of non-invasive vagus nerve stimulation for the treatment of chronic cluster headache

. Simon Walker is an employee of Cogentia Healthcare Consulting Ltd. Eric Liebler is an employee of electroCore, LLC, and receives stock ownership. Charly Gaul has received honoraria from Allergan, Inc

Cost-effectiveness analysis of non-invasive vagus nerve stimulation for the treatment of chronic cluster headache

investigator fees paid to the Walton Centre. Simon Walker is an employee of Cogentia Healthcare Consulting Ltd. Eric Liebler is an employee of electroCore, LLC, and receives stock ownership. Charly Gaul has