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Arrestins: structural disorder creates rich functionality

-arrestin2 or hTHY-ARRX), and arrestin-4 (cone or X-arrestin). COMPLIANCE WITH ETHICS GUIDELINES Vsevolod V. Gurevich, Eugenia V. Gurevich, and Vladimir N. Uversky declare that they have no conflict of

The Origin and Evolution of G Protein-Coupled Receptor Kinases

G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling. Direct binding to active GPCRs activates GRKs, so that they selectively phosphorylate only the activated form of the receptor regardless of the accessibility...

Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum

Eugenia V. Gurevich 0 1 Veronique Sgambato-Faure, INSERM/CNRS, France 0 a Current address: Department of Pharmacology, Military Medical Academy , Saint-Petersburg , Russia b Current address: Department of

Arrestins: ubiquitous regulators of cellular signaling pathways

Summary In vertebrates, the arrestins are a family of four proteins that regulate the signaling and trafficking of hundreds of different G-protein-coupled receptors (GPCRs). Arrestin homologs are also found in insects, protochordates and nematodes. Fungi and protists have related proteins but do not have true arrestins. Structural information is available only for free (unbound...

Progressive Reduction of its Expression in Rods Reveals Two Pools of Arrestin-1 in the Outer Segment with Different Roles in Photoresponse Recovery

Light-induced rhodopsin signaling is turned off with sub-second kinetics by rhodopsin phosphorylation followed by arrestin-1 binding. To test the availability of the arrestin-1 pool in dark-adapted outer segment (OS) for rhodopsin shutoff, we measured photoresponse recovery rates of mice with arrestin-1 content in the OS of 2.5%, 5%, 60%, and 100% of wild type (WT) level by two...

Thalamo-cortical Afferents Control Transient Expression of the Dopamine D3 Receptor in the Rat Somatosensory Cortex

The D3 dopamine receptor (D3R) is selectively and transiently expressed in the barrel neurons of the somatosensory cortex (SI) between the first and second postnatal weeks. The D3R expression starts after the initial ingrowth of thalamocortical afferents (TCAs) into the barrel cortex and could be induced or controlled by them. We show that unilateral electrolytic lesion of the...