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16 papers found.
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CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma

Contributions Conceptualization: Eun Kyoung Kim, Xianglan Zhang, Jin Kim. Data curation: Eun Kyoung Kim, Xianglan Zhang, Jin Kim. Formal analysis: Eun Kyoung Kim. Funding acquisition: Jin Kim. Investigation ... : Eun Kyoung Kim, Sook Moon, Do Kyeong Kim. Methodology: Eun Kyoung Kim, Do Kyeong Kim. Project administration: Xianglan Zhang, Jin Kim. Resources: Jin Kim. Visualization: Do Kyeong Kim, Jin Kim

Segmented inner plexiform layer thickness as a potential biomarker to evaluate open-angle glaucoma: Dendritic degeneration of retinal ganglion cell

the authors has any proprietary interests in any device or drug mentioned in the Author Contributions Data curation: Eun Kyoung Kim. Formal analysis: Eun Kyoung Kim. Investigation: Eun Kyoung Kim ... . Conceptualization: Eun Kyoung Kim, Hae-Young Lopilly Park, Chan Kee Park. Methodology: Eun Kyoung Kim, Hae-Young Lopilly Park, Chan Kee Park. Resources: Eun Kyoung Kim. Software: Eun Kyoung Kim. Supervision: Hae

Enhanced cytomegalovirus infection in human trabecular meshwork cells and its implication in glaucoma pathogenesis

in:Nature Research journals • PubMed • Google ScholarSearch for Eun Kyoung Kim in:Nature Research journals • PubMed • Google ScholarSearch for Chan Kee Park in:Nature Research journals • PubMed • Google ... ScholarSearch for Soon-Young Paik in:Nature Research journals • PubMed • Google Scholar Contributions Jin A Choi wrote the main manuscript text. Jin A Choi, Joo Eun Kim, Seung-Jun Noh and Eun Kyoung Kim performed

Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus

Background Insulin plays diverse roles in the brain. Although insulin produced by pancreatic β-cells that crosses the blood–brain barrier is a major source of brain insulin, recent studies suggest that insulin is also produced locally within the brain. However, the mechanisms underlying the production of brain-derived insulin (BDI) are not yet known. Results Here, we examined the...

Control of adult neurogenesis by programmed cell death in the mammalian brain

The presence of neural stem cells (NSCs) and the production of new neurons in the adult brain have received great attention from scientists and the public because of implications to brain plasticity and their potential use for treating currently incurable brain diseases. Adult neurogenesis is controlled at multiple levels, including proliferation, differentiation, migration, and...

The impact of graduate students on research productivity in Korea

Even though graduate students are critical for carrying out research, they have not been treated as important in the existing literature on research productivity. Accordingly, this paper focuses on whether the number of graduate students has a significant impact on their supervisors’ research productivity. In order to address this question, we have collected a large scale data on...

Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal

Background Programmed cell death (PCD) plays essential roles in the regulation of survival and function of neural stem cells (NSCs). Abnormal regulation of this process is associated with developmental and degenerative neuronal disorders. However, the mechanisms underlying the PCD of NSCs remain largely unknown. Understanding the mechanisms of PCD in NSCs is crucial for exploring...

Atrial Fibrillation in Hypertrophic Cardiomyopathy: Is the Extent of Septal Hypertrophy Important?

Hypertrophic cardiomyopathy (HCM) is a cardiac disease associated with a high incidence of atrial fibrillation (AF). Recent studies have suggested that interventricular septum thickness may influence the risk stratification of patients with AF. We evaluated the effects of septal hypertrophy on morbidity and mortality in patients with HCM. Patients were followed for a median of 6...

Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal

Background Neural stem cells (NSCs) hold great potential for the treatment of neurodegenerative diseases. However, programmed cell death (PCD) provoked by the harsh conditions evident in the diseased brain greatly undermines the potential of NSCs. Currently, the mechanisms of PCD that effect NSCs remain largely unknown. Results We have previously reported that hippocampal neural...

Cathepsin Inhibition-Induced Lysosomal Dysfunction Enhances Pancreatic Beta-Cell Apoptosis in High Glucose

Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism for the survival of pancreatic β-cells. The current study demonstrates that treatment with inhibitors and knockdown of the...

Morphine Does Not Affect Myocardial Salvage in ST-Segment Elevation Myocardial Infarction

Recent studies have proposed intravenous (IV) morphine is associated with delayed action of antiplatelet agents in acute myocardial infarction. However, it is unknown whether morphine results in increased myocardial damage in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). We investigated myocardial salvage...

D-Dimer Levels Predict Myocardial Injury in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study

Objectives Elevated D-dimer levels on admission predict prognosis in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), but the association of D-dimer levels with structural markers of myocardial injury in these patients is unknown. Methods We performed cardiac magnetic resonance (CMR) imaging in 208...

Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation

Modification of hypothalamic fatty acid (FA) metabolism can improve energy homeostasis and prevent hyperphagia and excessive weight gain in diet-induced obesity (DIO) from a diet high in saturated fatty acids. We have shown previously that C75, a stimulator of carnitine palmitoyl transferase-1 (CPT-1) and fatty acid oxidation (FAOx), exerts at least some of its hypophagic effects...

Noncutaneous malignant melanoma: a prognostic model from a retrospective multicenter study

Background We performed multicenter study to define clinical characteristics of noncutaneous melanomas and to establish prognostic factors patients who received curative resection. Methods Of the 141 patients who were diagnosed of non-cutaneous melanoma at 4 institutions in Korea between June 1992 and May 2005, 129 (91.5%) satisfied the selection criteria. Results Of the 129...