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7 papers found.
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Protective effect of clusterin on rod photoreceptor in rat model of retinitis pigmentosa

clusterin. Conceptualization: Andrew Vargas, Hwa Sun Kim, Cheryl Mae Craft, Eun-Jin Lee. Data curation: Andrew Vargas, Hwa Sun Kim, Cheryl Mae Craft, Eun-Jin Lee. Formal analysis: Andrew Vargas, Hwa Sun Kim ... , Erika Baral, Wan-Qing Yu, Eun-Jin Lee. Funding acquisition: Cheryl Mae Craft, Eun-Jin Lee. Investigation: Andrew Vargas, Hwa Sun Kim, Erika Baral, Cheryl Mae Craft, Eun-Jin Lee. Methodology: Andrew

Development of a Shear Strength Equation for Beam–Column Connections in Reinforced Concrete and Steel Composite Systems

Yun-Chul Choi Ji-Ho Moon Eun-Jin Lee Keum-Sung Park Kang Seok Lee In this study, we propose a new equation that evaluates the shear strength of beam-column connections in reinforced concrete and steel

Inhibition of Matrix Metalloproteinase 9 Enhances Rod Survival in the S334ter-line3 Retinitis Pigmentosa Model

Retinitis Pigmentosa (RP) is one of the most common forms of inherited visual loss with the initial degeneration of rod photoreceptors, followed by a progressive cone photoreceptor deterioration. Coinciding with this visual loss, the extracellular matrix (ECM) is reorganized, which alters matrix metalloproteinase (MMP) activity levels. A potential pathological role of MMPs, MMP-9...

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

Abstracts Background Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study, we report generation and phenotypic characterization of IL2RG knockout female pigs...

Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of ZO-1 Expression in DL-Alpha-Aminoadipic Acid Reshaping

In S334ter-line-3 rat model of Retinitis Pigmentosa (RP), rod cell death induces the rearrangement of cones into mosaics of rings while the fibrotic processes of Müller cells remodel to fill the center of the rings. In contrast, previous work established that DL-alpha-aminoadipic-acid (AAA), a compound that transiently blocks Müller cell metabolism, abolishes these highly...

High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation

Backgound The formation of bony spurs and ankylosis is a key pathognomic feature in ankylosing spondylitis (AS) and results in functional impairment. The aim of this study was to investigate the role of IL-32γ in osteoblast (OB) differentiation and its association with the pathogenesis of AS. Methods The concentration and expression of IL-32γ were evaluated in synovial fluid and...

Loose Plant Architecture1 (LPA1) determines lamina joint bending by suppressing auxin signalling that interacts with C-22-hydroxylated and 6-deoxo brassinosteroids in rice

Lamina inclination is a key agronomical character that determines plant architecture and is sensitive to auxin and brassinosteroids (BRs). Loose Plant Architecture1 (LPA1) in rice (Oryza sativa) and its Arabidopsis homologues (SGR5/AtIDD15) have been reported to control plant architecture and auxin homeostasis. This study explores the role of LPA1 in determining lamina...