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Efficacy and tolerability of rivastigmine patch therapy in patients with mild-to-moderate Alzheimer’s dementia associated with minimal and moderate ischemic white matter hyperintensities: A multicenter prospective open-label clinical trial

Park, Eun-Joo Kim, Seong Hye Choi. Data curation: Kyung Won Park, Eun-Joo Kim, Hyun Jeong Han, Yong S. Shim, Jae C. Kwon, Bon D. Ku, Kee Hyung Park, Hyon-Ah Yi, Kwang K. Kim, Dong Won Yang, Ho Won Lee ... : Kyung Won Park, Seong Hye Choi. Investigation: Kyung Won Park, Eun-Joo Kim, Hyun Jeong Han, Yong S. Shim, Jae C. Kwon, Bon D. Ku, Kee Hyung Park, Hyon-Ah Yi, Kwang K. Kim, Dong Won Yang, Ho-Won Lee

Happier People Show Greater Neural Connectivity during Negative Self-Referential Processing

Life satisfaction is an essential component of subjective well-being and provides a fundamental resource for optimal everyday functioning. The goal of the present study was to examine how life satisfaction influences self-referential processing of emotionally valenced stimuli. Nineteen individuals with high life satisfaction (HLS) and 21 individuals with low life satisfaction (LLS) ...

Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study

Despite the clinical impact of non-motor symptoms (NMS) in Parkinson’s disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor ...

Social Transmission of Fear in Rats: The Role of 22-kHz Ultrasonic Distress Vocalization

Background Social alarm calls alert animals to potential danger and thereby promote group survival. Adult laboratory rats in distress emit 22-kHz ultrasonic vocalization (USV) calls, but the question of whether these USV calls directly elicit defensive behavior in conspecifics is unresolved. Methodology/Principal Findings The present study investigated, in pair-housed male rats, ...

Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia

Behavioral variant frontotemporal dementia (bvFTD) erodes complex social–emotional functions as the anterior cingulate cortex (ACC) and frontoinsula (FI) degenerate, but the early vulnerable neuron within these regions has remained uncertain. Previously, we demonstrated selective loss of ACC von Economo neurons (VENs) in bvFTD. Unlike ACC, FI contains a second conspicuous layer 5 ...

Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells

Human sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that participates in cell death/survival, senescence and metabolism. Although its substrates are well characterized, no direct regulators have been defined. Here, we show that SIRT1 associates with SKI-interacting protein (SKIP) and modulates its activity as a coactivator of retinoic acid receptor (RAR). Binding assays ...

Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML

We performed a yeast two‐hybrid screen using p73α, which is a member of the p53 family, as bait. We found that the p53 family members were functionally associated with Daxx, which was described originally as a cytoplasmic mediator of Fas signaling, but has been identified recently as a nuclear protein that co‐localizes with the promyelocytic leukemia (PML) protein and regulates ...