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15 papers found.
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Genetic lesions in diffuse large B-cell lymphomas

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults, accounting for 35%–40% of all cases. The combination of the anti-CD20 monoclonal antibody rituximab with anthracycline-based combination chemotherapy (R-CHOP, rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) lead to complete remission in most and can cure more than half of...

Large genomic aberrations detected by SNP array are independent prognosticators of a shorter time to first treatment in chronic lymphocytic leukemia patients with normal FISH

Background Genomic complexity can predict the clinical course of patients affected by chronic lymphocytic leukemia (CLL) with a normal FISH. However, large studies are still lacking. Here, we analyzed a large series of CLL patients and also carried out the so far largest comparison of FISH versus single-nucleotide polymorphism (SNP) array in this disease.

Long-term outcome following Helicobacter pylori eradication in a retrospective study of 105 patients with localized gastric marginal zone B-cell lymphoma of MALT type

Background: Treatment aimed at eradicating Helicobacter pylori infection results in lymphoma remission in most localized gastric mucosa-associated lymphoid tissue (MALT) lymphomas. The aim of this survey is to investigate the long-term effect of this therapeutic approach in a large series of patients. Methods: One hundred and five patients with localized gastric MALT lymphoma...

cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter

Cyclic adenosine 3′-5′-monophosphate (cAMP) is a second messenger, which exerts an important role in the control of human first-trimester trophoblast functions. In the present study we demonstrate the existence of a mechanism that is able to extrude cAMP from trophoblast-derived cell lines, and show evidence indicating the involvement of multidrug resistance protein (MRP) 1, a...

Clinical and molecular characterization of diffuse large B-cell lymphomas with 13q14.3 deletion

Background: Deletions at 13q14.3 are common in chronic lymphocytic leukemia and are also present in diffuse large B-cell lymphomas (DLBCL) but never in immunodeficiency-related DLBCL. To characterize DLBCL with 13q14.3 deletions, we combined genome-wide DNA profiling, gene expression and clinical data in a large DLBCL series treated with rituximab, cyclophosphamide, doxorubicine...

Predictive factors of disease-free survival for non-metastatic osteosarcoma of the extremity: An analysis of 300 patients treated at the Rizzoli Institute

S. Ferrari F. Bertoni M. Mercuri P. Picci 0 S. Giacomini A. Longhi G. Bacci 0 Laboratory of Oncologic Research of the Musculoskeletal Oncology Department of the Islitnti Ortopedici Rizzoli , Bologna

In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas†

Background:: Mantle cell lymphoma (MCL) has the worst prognosis of all B-cell lymphomas and has poor response to conventional therapy. It is characterized by the presence of a chromosomal translocation t(11:14) (q13;q32) which results in deregulated cyclin D1 expression. Since defects in cell cycle regulation and apoptosis are primary events in MCL, small-molecule inhibitors of...

Allelic expression of p73 in human ovarian cancers

M. Broggini 1 0 Ospedale S. Gerardo, University of Milan , Monza (MI) , Italy 1 A. M. Codegoni , F. Bertoni, C. Patregnani, E. Marinetti, M. D'lncalci 2 Molecular Pharmacology Unit, Department of

Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone

G. Gamberi M. S. Benassi P. Ragazzini L. Pazzaglia F. Ponticelli C. Ferrari A. Balladelli M. Mercuri M. Gigli F. Bertoni 0 P. Picci 0 Pathology, Department of Musculoskeletal Oncology, Istituto

Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide

Background: Effective adjuvant or neoadjuvant regimens of chemotherapy have dramatically improved the prognosis of patients with high-grade osteosarcoma of the extremity, localized at diagnosis. Currently, little is known about patients with metastatic disease at presentation. Patients and methods: From May 1995 to May 2000, 57 patients with osteosarcoma of the extremity...

Clinical significance of bcl-2 (MBR)/JH rearrangement in the peripheral blood of patients with diffuse large B-cell lymphomas

E. Zucca F. Bertoni G. Bosshard E. Roggero E. Ceresa P. Sanna E. Pedrinis 0 F. Cavalli 0 Istituto Cantonale di Patologia , Locarno , Switzerland Summary Background: Approximately one-fourth of

Microsatellite instability in gastric MALT lymphomas and other associated neoplasms

Background: Microsatellite instability (MSI), caused by a reduced efficacy of the DNA mismatch repair (MMR) machinery, represents a type of genomic instability frequently detected in HNPCC spectrum cancers and in a subset of sporadic carcinomas. The involvement of MSI in the pathogenesis of gastric lymphoma of mucosa-associated lymphoid tissue (MALT) has never been conclusively...

Metalloproteinase expression and prognosis in soft tissue sarcomas

Background Degradation of extracellular matrix by tumor-associated proteases can promote cell invasion and metastasis This study assessed the prognostic role of MMP2, MMP9 metalloproteinases, and of the metalloproteinase inhibitor TIMP2, related to disease-free survival (DFS), in soft tissue sarcoma (STS) patients Materials and methods Level and distribution of MMP2, MMP9, and...

Treatment and prognosis in a series of primary extranodal lymphomas of the ocular adnexa

L. Baldini M. Blini 0 A. Guffanti V. Fossati A. Alietti A. Neri G. Bertoni 0 M. Colombi M. L. LaTargia F. Bertoni 0 Clinica Oculislica deliliniversila di Milano , Ospedale L. Sacco 1 Dipartimento di