Advanced search    

Search: authors:"Fang Niu"

14 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis

Background Neuroinflammation associated with advanced human immunodeficiency virus (HIV)-1 infection is often exacerbated by chronic cocaine abuse. Cocaine exposure has been demonstrated to mediate up-regulation of inflammatory mediators in in vitro cultures of microglia. The molecular mechanisms involved in this process, however, remain poorly understood. In this study, we...

Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum

Background The marine diatom, Phaeodactylum tricornutum, has become a model for studying lipid metabolism and its triacylglycerol (TAG) synthesis pathway makes it an ideal target for metabolic engineering to improve lipid productivity. However, the genetic background and metabolic networks of fatty acid biosynthesis in diatoms are not well understood. Glycerol-3-phosphate...

In situ loading of Cu2O nanoparticles on a hydroxyl group rich TiO2 precursor as an excellent catalyst for the Ullmann reaction

An in situ method has been used to load Cu2O nanoparticles on the surface of a hydroxyl group rich TiO2 precursor. Cu2O nanoparticles are formed by in situ reduction of Cu(OH)2 with Sn2+ ions linked to the surface of the TiO2 precursor. The initial Cu2O nanoparticles serve as seeds for subsequent particle growth. The resulting Cu2O nanoparticles are evenly dispersed on the...

Antisense knockdown of pyruvate dehydrogenase kinase promotes the neutral lipid accumulation in the diatom Phaeodactylum tricornutum

Background Microalgae have been an emerging biofuel resource; however, the germplasm improvement has been slow due to the lack of molecular tools. Pyruvate dehydrogenase kinase (PDK) deactivates the pyruvate dehydrogenase complex (PDC) which catalyzes the oxidative decarboxylation of pyruvate. Acetyl-CoA production via PDC is important in plant tissues that are active in fatty...

Glycerol and neutral lipid production in the oleaginous marine diatom Phaeodactylum tricornutum promoted by overexpression of glycerol-3-phosphate dehydrogenase

Yang Lu 0 Kun-Tao Peng Tan Huang Ying-Fang Niu Wei-Hong Xie Wei-Dong Yang Jie-Sheng Liu Hong-Ye Li 0 Equal contributors Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher

Stereoselective Regulations of P-Glycoprotein by Ginsenoside Rh2 Epimers and the Potential Mechanisms From the View of Pharmacokinetics

Chirality is an interesting topic and it is meaningful to explore the interactions between chiral small molecules and stereoselective biomacromolecules, with pre-clinical and clinical significances. We have previously demonstrated that 20(S)-ginsenoside Rh2 is an effective P-glycoprotein (P-gp) inhibitor in vitro and in vivo. Considering the stereochemistry of ginsenoside Rh2, in...

Molecular and cellular mechanisms of neutral lipid accumulation in diatom following nitrogen deprivation

Background Nitrogen limitation can induce neutral lipid accumulation in microalgae, as well as inhibiting their growth. Therefore, to obtain cultures with both high biomass and high lipid contents, and explore the lipid accumulation mechanisms, we implemented nitrogen deprivation in a model diatom Phaeodactylum tricornutum at late exponential phase. Results Neutral lipid contents...

A1C and Cardiovascular Outcomes in Type 2 Diabetes: A nested case-control study

DANIELLE C. COLAYCO PHARMD MS FANG NIU MS JEFFREY S. MCCOMBS PHD T. CRAIG CHEETHAM PHARMD MS E p i d e m i o l o g y / H e a l t h OBJECTIVE - Type 2 diabetes is associated with increased

Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response

Background Resveratrol (RES), a natural phytoalexin found at high levels in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. However, the underlying molecular mechanisms are at present only partially understood. Method The effects of RES on activation of unfolded protein responses (UPR) were evaluated using Western...

Aquaporin3 Is Required for FGF-2-Induced Migration of Human Breast Cancers

Purpose The aquaporin (AQP) family consists of a number of small integral membrane proteins that transport water and glycerol. AQPs are critical for trans-epithelial fluid transport. Recent reports demonstrated that AQPs, particularly AQP1 and AQP5, are expressed in high grade tumor cells of a variety of tissue origins, and that AQPs are involved in cell migration and metastasis...

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

of IP‐10 from pericytes: implication for monocyte recruitment into the CNS Fang Niu, Shilpa Buch Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha

A Novel First Aid Stretcher for Immobilization and Transportation of Spine Injured Patients

Effective immobilization and transportation are vital to the life-saving acute medical care needed when treating critically injured people. However, the most common types of stretchers used today are wrought with problems that can lead to further medical complications, difficulty in employment and rescue, and ineffective transitions to hospital treatment. Here we report a novel...

Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1

Background It was reported recently that resveratrol could sensitize a number of cancer cells to the antitumoral effects of some conventional chemotherapy drugs. The current study was designed to investigate whether resveratrol could sensitize leukemic cells to proteasome inhibitors. Methods Leukemic cells were treated with MG132 alone or in combination with resveratrol. Cell...

Soybean Trihelix Transcription Factors GmGT-2A and GmGT-2B Improve Plant Tolerance to Abiotic Stresses in Transgenic Arabidopsis

Background Trihelix transcription factors play important roles in light-regulated responses and other developmental processes. However, their functions in abiotic stress response are largely unclear. In this study, we identified two trihelix transcription factor genes GmGT-2A and GmGT-2B from soybean and further characterized their roles in abiotic stress tolerance. Findings Both...