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Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies

study received no specific external funding. Authors have disclosed no conflicts of interest. 11 / 14 Author Contributions Data curation: Fei Cheng, Mi Zhang, Xiao Dong, Zhen Gao. Formal analysis: Fei ... Cheng, Mi Zhang, Jiajuan Chen. Investigation: Quan Wang. Methodology: Fei Cheng, Jiajuan Chen. Software: Quan Wang, Haijun Xu, Zhen Gao, Yunjie Wei, Fen Qin. Supervision: Fen Qin. Validation: Haijun

Fungal community structure of fallen pine and oak wood at different stages of decomposition in the Qinling Mountains, China

Author notes Jie Yuan and Xiaofeng Zheng contributed equally to this work. AffiliationsCollege of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaJie Yuan, Xiaofeng Zheng, Fei Cheng ... AuthorsSearch for Jie Yuan in:Nature Research journals • PubMed • Google Scholar Search for Xiaofeng Zheng in:Nature Research journals • PubMed • Google Scholar Search for Fei Cheng in:Nature Research journals

Decay and nutrient dynamics of coarse woody debris in the Qinling Mountains, China

As an ecological unit, coarse woody debris (CWD) plays an essential role in productivity, nutrient cycling, carbon sequestration, community regeneration and biodiversity. However, thus far, the information on quantification the decomposition and nutrient content of CWD in forest ecosystems remains considerably limited. In this study, we conducted a long-term (1996–2013) study on...

Ultrasensitive detection and characterization of molecules with infrared plasmonic metamaterials

AuthorsSearch for Fei Cheng in:Nature Research journals • PubMed • Google ScholarSearch for Xiaodong Yang in:Nature Research journals • PubMed • Google ScholarSearch for Jie Gao in:Nature Research journals

The Prognostic Role of the Platelet-Lymphocytes Ratio in Gastric Cancer: A Meta-Analysis

Background Systemic inflammatory parameters, such as the elevator PLR (platelet-lymphocyte ratio), the NLR (neutrophil-lymphocyte ratio) and the platelet count (PLT), have been found to be associated with the prognosis in gastric cancer; however, these results, especially those relating to the PLR, remain inconsistent. So we aimed to evaluate the prognostic role of the PLR in...

The octanol/water distribution coefficients of ardipusilloside-I and its metabolites, and their permeation characteristics across Caco-2 cell monolayer

Background Ardipusilloside-I (ADS-I) is a triterpenoid saponin extracted from Chinese medicinal herb Ardisiapusill A. DC. Previous studies have demonstrated the potent anti-tumor activities of ADS-I both in vitro and in vivo, and its main metabolites (M1 and M2) from human intestinal bacteria. However, the physicochemical properties and intestinal permeation rate of ADS-I and its...

Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice

This study focused on the unique properties of both the Ldlr knockout defect (closely mimicking the human situation) and the BALB/c (C) inbred mouse strain (Th-2 slanted immune response). We generated two immunodeficient strains with severe combined B- and T-cell immunodeficiency with or without a complete lack of natural killer cells to revisit the role of adaptive immune...

Evaluation of Appropriate Reference Genes for Gene Expression Normalization during Watermelon Fruit Development

Gene expression analysis in watermelon (Citrullus lanatus) fruit has drawn considerable attention with the availability of genome sequences to understand the regulatory mechanism of fruit development and to improve its quality. Real-time quantitative reverse-transcription PCR (qRT-PCR) is a routine technique for gene expression analysis. However, appropriate reference genes for...

Effect of Low pH and Aluminum Toxicity on the Photosynthetic Characteristics of Different Fast-Growing Eucalyptus Vegetatively Propagated Clones

Knowing how acid soils and aluminum in soils may limit the growth of Eucalyptus trees in plantations is important because these plantations grow in many tropical and subtropical regions. Seedlings of four vegetatively propagated Eucalyptus clones, E. grandis × E. urophylla ‘GLGU9’(G9), E. grandis × E. urophylla ‘GLGU12’ (G12), E. urophylla × E. camaldulensis ‘GLUC3’ (G3) and E...

Interactions between 2-Cys peroxiredoxins and ascorbate in autophagosome formation during the heat stress response in Solanum lycopersicum

2-Cys peroxiredoxins (2-CPs) function in the removal of hydrogen peroxide and lipid peroxides but their precise roles in the induction of autophagy have not been characterized. Here we show that heat stress, which is known to induce oxidative stress, leads to the simultaneous accumulation of transcripts encoding 2-CPs and autophagy proteins, as well as autophagosomes, in tomato...

MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin

Jie Liu 0 Fei Cheng 0 Lih-Wen Deng 0 0 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 8 Medical Drive , 117597

Chloroplastic thioredoxin-f and thioredoxin-m1/4 play important roles in brassinosteroids-induced changes in CO2 assimilation and cellular redox homeostasis in tomato

Chloroplast thioredoxins (TRXs) and glutathione function as redox messengers in the regulation of photosynthesis. In this work, the roles of chloroplast TRXs in brassinosteroids (BRs)-induced changes in cellular redox homeostasis and CO2 assimilation were studied in the leaves of tomato plants. BRs-deficient d ^im plants showed decreased transcripts of TRX-f, TRX-m2, TRX-m1/4...

A Test Data Compression Scheme Based on Irrational Numbers Stored Coding

Test question has already become an important factor to restrict the development of integrated circuit industry. A new test data compression scheme, namely irrational numbers stored (INS), is presented. To achieve the goal of compress test data efficiently, test data is converted into floating-point numbers, stored in the form of irrational numbers. The algorithm of converting...

Commutability of Possible External Quality Assessment Materials for Cardiac Troponin Measurement

Background The measurement of cardiac troponin is crucial in the diagnosis of myocardial infarction. The performance of troponin measurement is most conveniently monitored by external quality assessment (EQA) programs. The commutability of EQA samples is often unknown and the effectiveness of EQA programs is limited. Methods Commutability of possible EQA materials was evaluated...

Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis

Clinical and experimental evidence suggests a protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx-1) in the atherogenic process. GPx-1 deficiency accelerates atherosclerosis and increases lesion cellularity in ApoE−/− mice. However, the distribution of GPx-1 within the atherosclerotic lesion as well as the mechanisms leading to increased macrophage numbers in...

Global informetric perspective studies on translational medical research

Background Translational medical research literature has increased rapidly in the last few decades and played a more and more important role during the development of medicine science. The main aim of this study is to evaluate the global performance of translational medical research during the past few decades. Methods Bibliometric, social network analysis, and visualization...

Soil Microbial Biomass, Basal Respiration and Enzyme Activity of Main Forest Types in the Qinling Mountains

Different forest types exert essential impacts on soil physical-chemical characteristics by dominant tree species producing diverse litters and root exudates, thereby further regulating size and activity of soil microbial communities. However, the study accuracy is usually restricted by differences in climate, soil type and forest age. Our objective is to precisely quantify soil...

Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study

Background Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose this disorder. The aim of the present study was to characterize the alternations of glucose metabolites and identify potential diagnostic biomarkers for...

T Cell-Specific Overexpression of TGFß1 Fails to Influence Atherosclerosis in ApoE-Deficient Mice

Clinical data have indicated a negative correlation between plasma TGFß1 concentrations and the extent of atherosclerosis and have thus led to the hypothesis that the pleiotropic cytokine may have anti-atherogenic properties. T-cells are currently discussed to significantly participate in atherogenesis, but the precise role of adaptive immunity in atherogenesis remains to be...

High codon adaptation in citrus tristeza virus to its citrus host

BackgroundCitrus tristeza virus (CTV), a member of the genus Closterovirus within the family Closteroviridae, is the causal agent of citrus tristeza disease. Previous studies revealed that the negative selection, RNA recombination and gene flow were the most important forces that drove CTV evolution. However, the CTV codon usage was not studied and thus its role in CTV evolution...