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Effects of the silencing of CmMET1 by RNA interference in chrysanthemum (Chrysanthemum morifolium)

DNA methylation is an epigenetic modification involving many biological processes. It is known that epigenetic mechanisms such as cytosine methylation play a pivotal role in regulating plant development. In this current study, a conservative domain-spliced hairpin RNA (ihpRNA) plant expression vector aimed at gene of DNA METHYLTRANSFERASE1 (CmMET1) has been constructed...

Application of Metabolomics in the Study of Natural Products

LC–MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro...

Deep millimeter spectroscopy observations toward NGC 1068

Aims. We aim for a better understanding of gas properties in the circum-nuclear disk (CND) region of the nearby gas-rich Seyfert 2 galaxy NGC 1068. We focus on line identification and the basic physical parameters estimation of molecular gas in the CND region.Methods. We used the IRAM 30 m telescope to conduct deep millimeter spectroscopy observations toward the center of NGC...

A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis

A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis Xi-xi Xu,1 Jian-ping Bi,2 Li Ping,3 Ping Li,1 Fei Li1,4 1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Orthopedics Department, Shandong Provincial Traditional Chinese Medical Hospital, Affiliated...

New approximation methods for solving elliptic boundary value problems via Picard-Mann iterative processes with mixed errors

In this paper, we introduce and study a class of new Picard-Mann iterative methods with mixed errors for common fixed points of two different nonexpansive and contraction operators. We also give convergence and stability analysis of the new Picard-Mann iterative approximation and propose numerical examples to show that the new Picard-Mann iteration converges more effectively than...

Specialized core bacteria associate with plants adapted to adverse environment with high calcium contents

corporation for the technical support. Author Contributions Conceptualization: Fei Li. Data curation: Fei Li. Formal analysis: Fei Li. Funding acquisition: Fei Li. Investigation: Fei Li, Lunxian Liu ... . Methodology: Fei Li, Ximin Zhang, Jiyi Gong. Resources: Jiyi Gong, Lunxian Liu. Software: Ximin Zhang. Validation: Ximin Zhang. Writing ± original draft: Fei Li. Writing ± review & editing: Fei Li, Yin Yi

Donor lymphocyte infusion for prevention of relapse after unmanipulated haploidentical PBSCT for very high-risk hematologic malignancies

Unmanipulated haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) has been an established treatment to cure high-risk leukemia/lymphoma. Relapse is the main cause of treatment failure for patients with relapsed/refractory disease or with very high-risk gene mutations such as TP53, TET2, and DNMT3a. In this study, we aimed to establish the tolerance and...

A teleost CD46 is involved in the regulation of complement activation and pathogen infection

Academy of Sciences, Qingdao, ChinaMo-fei Li, Zhi-hai Sui & Li SunLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaMo-fei Li & Li ... SunUniversity of Chinese Academy of Sciences, Beijing, ChinaZhi-hai Sui AuthorsSearch for Mo-fei Li in:Nature Research journals • PubMed • Google Scholar Search for Zhi-hai Sui in:Nature Research journals

The current status of clinical trials focusing on nasopharyngeal carcinoma: A comprehensive analysis of database

). Author Contributions Conceptualization: Hao Peng, Lei Chen, Jun Ma. Data curation: Hao Peng, Lei Chen, Yu-Pei Chen. Formal analysis: Hao Peng, Yu-Pei Chen, Wen-Fei Li, Ling-Long Tang, Ai-Hua Lin ... . Funding acquisition: Jun Ma. Methodology: Lei Chen, Yu-Pei Chen. Project administration: Wen-Fei Li. Software: Hao Peng, Yu-Pei Chen, Wen-Fei Li, Ai-Hua Lin. Supervision: Jun Ma. Validation: Hao Peng

Metformin add-on continuous subcutaneous insulin infusion on precise insulin doses in patients with type 2 diabetes

). Author information Author notes Feng-fei Li, Bing-li Liu, Guo-ping Yin, Reng-na Yan and Danfeng Zhang contributed equally to this work. AffiliationsDepartment of Endocrinology, Nanjing First Hospital ... , Nanjing Medical University, Nanjing, ChinaFeng-fei Li, Bing-li Liu, Guo-ping Yin, Reng-na Yan, Dan-feng Zhang, Jin-dan Wu, Xiao-fei Su & Jian-hua MaNational Heart Research Institute Singapore, National

Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells

improve our paper. Author information Author notes Cheng-Fei Li and Jia-Xing Sun contributed equally to this work. Edited by B. Zhivotovsky AffiliationsDepartment of Aerospace Biodynamics, School of ... Aerospace Medicine, Fourth Military Medical University, Xi’an, 710032, ChinaCheng-Fei Li, Yuan Gao, Fei Shi, Yi-Kai Pan & Xi-Qing SunKey lab of Aerospace Medicine, Chinese Ministry of Education, Xi’an

Assessment of municipal infrastructure development and its critical influencing factors in urban China: A FA and STIRPAT approach

and Baoji; Gansu ProvinceÐJiayuguan; Jiangxi ProvinceÐXinyu and Pingxiang; and Ningxia Hui Autonomous RegionÐShizuishan. Author Contributions Conceptualization: Yu Li, Fei Li. Data curation: Ji Zheng ... , Xueting Jin, Chen Xu. Formal analysis: Ji Zheng, Chen Xu. Investigation: Yu Li, Fei Li, Xueting Jin. Methodology: Fei Li. Project administration: Yu Li, Fei Li. Software: Yu Li, Ji Zheng, Fei Li

Differential Treatment Response to Insulin Intensification Therapy: A Post Hoc Analysis of a Randomized Trial Comparing Premixed and Basal-Bolus Insulin Regimens

Lilly and Company for their support in peer review. The authors also thank Fei Li of Eli Lilly and Company for assistance in publication project management. The authors would like to thank all study ... of the data and accuracy of the data analysis. Li Xin Shi was involved in the interpretation of data for the work. Peng Fei Li was involved in the analysis and interpretation of data for the work. Jia

Comparison of Efficacy and Safety of Lispro and Aspart Evaluated by Continuous Glucose Monitoring System in Patients with Newly Diagnosed Type 2 Diabetes

’ Contributions Bing-li Liu, Guo-ping Yin, and Feng-fei Li contributed equally to this work. Acknowledgments The authors thank all patients and control subjects for participating in this study. This study was

Correction: De novo assembly and analysis of the transcriptome of Rumex patientia L. during cold stress

Liu , Yongqing Xu, Liguo Zhang, Wei Li, Zhenxue Cai, Fei Li, Mu Peng, Fenglan Li The affiliations for authors Liguo Zhang and Wei Li are incorrect. Liguo Zhang and Wei Ling are not affiliated with #1

An overview of the mission and technical characteristics of Change’4 Lunar Probe

Change’4 Lunar Probe will softly land on the farside of the Moon for the first time of all mankind and carry out in-situ and rovering exploration. In this paper, the scientific significance and engineering difficulties of Change’4 are introduced and the probe’s general design, including the aspects of landing site selection, relay communication, trajectory design of relay...

mTOR complexes differentially orchestrates eosinophil development in allergy

, Hangzhou, Zhejiang, 310009, ChinaChen Zhu, Lixia Xia, Fei Li, Lingren Zhou, Qingyu Weng, Zhouyang Li, Yinfang Wu, Chao Zhang, Yanping Wu, Miao Li, Songmin Ying, Zhihua Chen, Huahao Shen & Wen LiDepartment of ... AuthorsSearch for Chen Zhu in:Nature Research journals • PubMed • Google Scholar Search for Lixia Xia in:Nature Research journals • PubMed • Google Scholar Search for Fei Li in:Nature Research journals • PubMed

Antimicrobial peptide gene BdPho responds to peptidoglycan infection and mating stimulation in oriental fruit fly, Bactrocera dorsalis (Hendel)

Phormicins belong to defensin family, which are important antimicrobial peptides (AMPs) in insects. These AMPs are inducible upon challenging by immune triggers. In the present study, we identified the cDNA of a phormicin gene (BdPho) in the oriental fruit fly, Bactrocera dorsalis (Hendel), a ruinous agricultural pest causing great economic losses to fruits and vegetables. The...

Research on Learning from Demonstration of Mobile Robot with Autonomous Navigation

A new method of batch learning from Demonstration is presented, in order to solve the problem of mobile robot independent navigation. According to the actual situation, the model of the Learning form Demonstration is given, and the neural network is used to realize the robot’s learning. Considering that the single artificial neural network cause dimension disaster, we designed...