Advanced search    

Search: authors:"Fei Luo"

33 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Hypertriglyceridemia and atherosclerosis

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and it has been confirmed that increased low density lipoprotein cholesterol (LDL-C) is an independent risk factor for atherosclerosis. Recently, the increasing evidence has showed that hypertriglyceridemia is associated with incremental ASCVD risk. But the proatherogenic mechanism of triglyceride (TG...

TGFβ3 recruits endogenous mesenchymal stem cells to initiate bone regeneration

Background The recruitment of a sufficient number of endogenous mesenchymal stem cells (MSCs) is the first stage of in-situ tissue regeneration. Transforming growth factor beta-3 (TGFβ3) could recruit stem or progenitor cells and endothelial cells to participate in tissue regeneration. However, the mechanism of TGFβ3 recruiting MSCs toward bone regeneration has remained obscure...

Targeted release of stromal cell-derived factor-1α by reactive oxygen species-sensitive nanoparticles results in bone marrow stromal cell chemotaxis and homing, and repair of vascular injury caused by electrical burns

-Wei Deng for their experimental technical assistance. Author Contributions Conceptualization: Zhi-Bao Huo, Guang-Yi Wang, Zhao-Fan Xia. Formal analysis: Fang He, Peng-Fei Luo, Tao Tang. Funding ... acquisition: Guang-Yi Wang. Investigation: Fang He, Peng-Fei Luo, Tao Tang, Fang Zhang, He Fang, Shi-Zhao Ji. Methodology: Fang He, Peng-Fei Luo, Tao Tang, Yu Sun, Guo-Sheng Wu, Bo-Han Pan. Project

Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions

Atherosclerosis is a chronic inflammatory disease with complex pathological processes. MicroRNA-33 (miR-33), a novel non-coding RNA that coexpresses with sterol regulatory element-binding proteins (SREBPs), affects macrophage actions to prevent atherosclerosis. Fibroblast growth factor 21 (FGF21) is an important regulator of lipid metabolism, especially for macrophage-related...

Predicting potential drug-drug interactions by integrating chemical, biological, phenotypic and network data

Background Drug-drug interactions (DDIs) are one of the major concerns in drug discovery. Accurate prediction of potential DDIs can help to reduce unexpected interactions in the entire lifecycle of drugs, and are important for the drug safety surveillance. Results Since many DDIs are not detected or observed in clinical trials, this work is aimed to predict unobserved or...

A genetic algorithm-based weighted ensemble method for predicting transposon-derived piRNAs

Background Predicting piwi-interacting RNA (piRNA) is an important topic in the small non-coding RNAs, which provides clues for understanding the generation mechanism of gamete. To the best of our knowledge, several machine learning approaches have been proposed for the piRNA prediction, but there is still room for improvements. Results In this paper, we develop a genetic...

Prognostic implications of preoperative anemia in urothelial carcinoma: A meta-analysis

The prognostic significance of preoperative anemia (PA) has been identified in various malignancies. However, its predictive role in urothelial carcinoma (UC) remains controversial. The aim of this study was to investigate the prognostic value of PA in UC patients. We performed a meta-analysis of the association between PA and survival outcome in UC patients. Electronic databases...

The outcomes of chemotherapy only treatment on mild spinal tuberculosis

Background The treatments for spinal tuberculosis (TB) patients without absolute surgical indications have been controversial. Some people believed that most spinal TB patients were indicated for surgery, while other people believed in chemotherapy only. To help clarify the treatment over spinal TB patients without absolute surgical indications, we characterized a subtype spinal...

Induction of granulation tissue for the secretion of growth factors and the promotion of bone defect repair

Background The use of the Masquelet technique in the repair of large bone defects has gained increased acceptance in recent years. The core of this technique is the induction of granulation tissue membrane formation and the implantation of an autologous cancellous bone to reconstruct bone defects in the membrane. In this study, we purpose to explore the structure of induced...

Overexpression of Hypo-Phosphorylated IκBβ at Ser313 Protects the Heart against Sepsis

IκBβis an inhibitor of nuclear factor kappa B(NF-κB) and participates in the cardiac response to sepsis. However, the role of the hypo-phosphorylated form of IκBβ at Ser313, which can be detected during sepsis, is unknown. Here, we examined the effects of IκBβ with a mutation at Ser313→Ala313 on cardiac damage induced by sepsis. Transgenic (Tg) mice were generated to overexpress...

Treatment effect, postoperative complications, and their reasons in juvenile thoracic and lumbar spinal tuberculosis surgery

Objective Fifty-four juvenile cases under 18 years of age with thoracic and lumbar spinal tuberculosis underwent focus debridement, deformity correction, bone graft fusion, and internal fixation. The treatment effects, complications, and reasons were analyzed retrospectively. Material and method There were 54 juvenile cases under 18 years of age with thoracolumbar spinal...

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases Zhi-ming Zeng,1 Fei-fei Luo,2 Lin-xia Zou,3 Rong-quan He,1 Deng-hua Pan,2 Xin Chen,2 Ting-ting Xie,2

Predicting target-ligand interactions using protein ligand-binding site and ligand substructures

Background Cell proliferation, differentiation, Gene expression, metabolism, immunization and signal transduction require the participation of ligands and targets. It is a great challenge to identify rules governing molecular recognition between chemical topological substructures of ligands and the binding sites of the targets. Methods We suppose that the ligand-target...

Could high-concentration rifampicin kill rifampicin-resistant M. tuberculosis? Rifampicin MIC test in rifampicin-resistant isolates from patients with osteoarticular tuberculosis

Purpose Several studies have shown that the intralesional concentration of rifampicin in osteoarticular tuberculosis is typically at a subtherapeutic level. Sustained or controlled release by novel drug delivery systems has been investigated to maintain an effective rifampicin concentration, but the local administration of rifampicin remains controversial. Additionally, it is...

Integrating peptides' sequence and energy of contact residues information improves prediction of peptide and HLA-I binding with unknown alleles

Background The HLA (human leukocyte antigen) class I is a kind of molecule encoded by a large family of genes and is characteristic of high polymorphism. Now the number of the registered HLA-I molecules has exceeded 3000. Slight differences in the amino acid sequences of HLAs would make them bind to different sets of peptides. In the past decades, although many methods have been...

Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis

Logistics Research Plan of PLA (BWS13C014). Author information AffiliationsDepartment of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing, ChinaCe Dou, Tianyong Hou, Fei Luo ... journals • PubMed • Google ScholarSearch for Ning Ding in:Nature Research journals • PubMed • Google ScholarSearch for Tianyong Hou in:Nature Research journals • PubMed • Google ScholarSearch for Fei Luo

Clinical significance of NUCB2 mRNA expression in prostate cancer

Background Nucleobindin 2 (NUCB2) abnormal expression has been reported in gastric cancer and breast cancer. However, the role of NUCB2 in prostate cancer (PCa) remains unclear. The aim of the present study was to investigate the NUCB2 expression in PCa tissues and adjacent non-cancerous tissues and its potential relevance to clinicopathological variables and prognosis. Methods...

Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

Intricate coordinated mechanisms that govern the synchrony of hair growth and melanin synthesis remain largely unclear. These two events can be uncoupled in prematurely gray hair, probably due to oxidative insults that lead to the death of oxidative stress-sensitive melanocytes. In this study, we examined the gene expression profiles of middle (bulge) and lower (hair bulb...