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Comparison of sentinel lymph node biopsy guided by indocyanine green, blue dye, and their combination in breast cancer patients: a prospective cohort study

study Jiajia Guo 0 Houpu Yang 0 Shu Wang Yingming Cao Miao Liu Fei Xie Peng Liu Bo Zhou Fuzhong Tong Lin Cheng Hongjun Liu Siyuan Wang 0 Equal contributors Peking University People's Hospital Breast

Effect of Twisted Fiber Anisotropy in Cardiac Tissue on Ablation with Pulsed Electric Fields

Background Ablation of cardiac tissue with pulsed electric fields is a promising alternative to current thermal ablation methods, and it critically depends on the electric field distribution in the heart. Methods We developed a model that incorporates the twisted anisotropy of cardiac tissue and computed the electric field distribution in the tissue. We also performed experiments...

Existence of periodic solutions for nonautonomous second-order discrete Hamiltonian systems

In this paper, we consider the existence of periodic solutions for a class of nonautonomous second-order discrete Hamiltonian systems in case the sum on the time variable of potential is periodic. The tools used in our paper are the direct variational minimizing method and Rabinowitz’s saddle point theorem. MSC: 34C25, 58E50.

Thermo-Electrochemical Cells Based on Carbon Nanotube Electrodes by Electrophoretic Deposition

Drawbacks of low efficiency and high cost of the electrode materials have restricted the wide applications of the thermo-electrochemical cells (TECs). Due to high specific areas and electrical conductivities, the low cost multi-walled carbon nanotubes (MWNTs) are promising alternative electrode materials. In this work, the MWNT films of up to 16 cm2 were synthesized on stainless...

Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma

Background O6-methylguanine-DNA methyltransferase (MGMT) methylation status has not been extensively investigated in duodenal adenocarcinoma (DA). The aim of this study was to evaluate the MGMT methylation status and examine its possible prognostic value in patients with stage III DA. Methods Demographics, tumor characteristics and survival were available for 64 patients with...

Somatosensory abnormalities in Chinese patients with painful temporomandibular disorders

and approved the final manuscript. Acknowledgements This study was supported by Capital Health Research and Development (Qiu-Fei Xie, 2011-4025-01) and Peking University School of Stomatology

Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation

Radiotherapy with heavy ions is considered advantageous compared to irradiation with photons due to the characteristics of the Braggs peak and the high linear energy transfer (LET) value. To understand the mechanisms of cellular responses to different LET values and dosages of heavy ion radiation, we analyzed the proteomic profiles of mouse embryo fibroblast MEF cells exposed to...

Ablation of Myocardial Tissue With Nanosecond Pulsed Electric Fields

Background Ablation of cardiac tissue is an essential tool for the treatment of arrhythmias, particularly of atrial fibrillation, atrial flutter, and ventricular tachycardia. Current ablation technologies suffer from substantial recurrence rates, thermal side effects, and long procedure times. We demonstrate that ablation with nanosecond pulsed electric fields (nsPEFs) can...

Intradermal microbubbles and contrast-enhanced ultrasound (CEUS) is a feasible approach for sentinel lymph node identification in early-stage breast cancer

Background Microbubbles and contrast-enhanced ultrasound (CEUS) is a new technique for locating sentinel lymph node (SLN). The aim of this study is to explore the feasibility of SLNs tracing by CEUS using microbubbles in breast cancer patients and the value of enhancing patterns in diagnosing lymph nodes metastases. Methods A clinical trial was registered (trial registration...

Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA)

The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer phage display random peptide library. After one round of prescreening and two rounds of screening, high-stringency screening at the...

26Al/10Be Burial Dating of Xujiayao-Houjiayao Site in Nihewan Basin, Northern China

The Xujiayao-Houjiayao site in Nihewan Basin is among the most important Paleolithic sites in China for having provided a rich collection of hominin and mammalian fossils and lithic artifacts. Based on biostratigraphical correlation and exploratory results from a variety of dating methods, the site has been widely accepted as early Upper Pleistocene in time. However, more recent...

Effect of negative emotions evoked by light, noise and taste on trigeminal thermal sensitivity

Guangju Yang 0 Lene Baad-Hansen Kelun Wang Qiu-Fei Xie 0 Peter Svensson 0 Department of Prosthodontics and Center for Oral Functional Diagnosis, Treatment and Research, Peking University School and

De novo Cloning and Annotation of Genes Associated with Immunity, Detoxification and Energy Metabolism from the Fat Body of the Oriental Fruit Fly, Bactrocera dorsalis

The oriental fruit fly, Bactrocera dorsalis, is a destructive pest in tropical and subtropical areas. In this study, we performed transcriptome-wide analysis of the fat body of B. dorsalis and obtained more than 59 million sequencing reads, which were assembled into 27,787 unigenes with an average length of 591 bp. Among them, 17,442 (62.8%) unigenes matched known proteins in the...

Delivering MC3T3-E1 cells into injectable calcium phosphate cement through alginate-chitosan microcapsules for bone tissue engineering

an injectable CPC scaffold to improve its effectiveness and function. Compliance with ethics guidelines Peng-yan QIAO, Fang-fang LI, Li-min DONG, Tao XU, and Qiu-fei XIE declare that they have no

The Meganuclease I-SceI Containing Nuclear Localization Signal (NLS-I-SceI) Efficiently Mediated Mammalian Germline Transgenesis via Embryo Cytoplasmic Microinjection

The meganuclease I-SceI has been effectively used to facilitate transgenesis in fish eggs for nearly a decade. I-SceI-mediated transgenesis is simply via embryo cytoplasmic microinjection and only involves plasmid vectors containing I-SceI recognition sequences, therefore regarding the transgenesis process and application of resulted transgenic organisms, I-SceI-mediated...

A New Model for Predicting Non-Sentinel Lymph Node Status in Chinese Sentinel Lymph Node Positive Breast Cancer Patients

Background Our goal is to validate the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram and Stanford Online Calculator (SOC) for predicting non-sentinel lymph node (NSLN) metastasis in Chinese patients, and develop a new model for better prediction of NSLN metastasis. Methods The MSKCC nomogram and SOC were used to calculate the probability of NSLN metastasis in 120 breast...

Molecular Characterization and Functions of Fatty Acid and Retinoid Binding Protein Gene (Ab-far-1) in Aphelenchoides besseyi

Rice white tip nematode, Aphelenchoides besseyi, is a kind of plant parasitic nematodes that cause serious losses in rice and many other crops. Fatty acid and retinoid binding protein (FAR) is a specific protein in nematodes and is related to development, reproduction, infection to the host, and disruption of plant defense reactions, so the inhibition of FAR function is the...

High-incidence of PTEN mutations in Chinese patients with primary small cell carcinoma of the esophagus

Background Primary small cell carcinoma of the esophagus (PSCCE) is a rare and aggressive tumor with poor prognosis. The aim of this study was to investigate the existence of EGFR, KRAS, PIK3CA and PTEN mutations in PSCCE. Methods Clinical–pathological data and paraffin-embedded specimens were collected from 38 patients. Exons 18 to 21 of EGFR, KRAS and PIK3CA status were...

iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway

associated with p53 pathway. Acknowledgements Dr JinFeng Chen is a recipient of the UICC international Fellowship. Dr Fei Xie is a recipient of the China Medical Scholarship of Cardiff University. The authors

The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance

Albert Hung Foundation for their support. The authors also thank Sevier Medical Art for their kind permission to produce some of present figures using their prepared images. Dr Fei Xie is a recipient of