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Injectable silicone rubber for ocular implantation after evisceration

. Ethical approval form. (PDF) Author Contributions Data curation: Peng Fei Zheng, Hong Yan Deng. Formal analysis: Peng Fei Zheng. Funding acquisition: Qi Sheng You, Xiao Yan Peng. Investigation: Hong ... : Qi Sheng You. Conceptualization: Peng Fei Zheng, Qian Li, Hong Yan Deng, Xiao Yan Peng. Writing ± review & editing: Qi Sheng You, Ian Y. H. Wong, Xiao Yan Peng. 9 / 10 1. Perman KI , Baylis HI

Improvement of the catalytic efficiency of a hyperthermophilic xylanase from Bispora sp. MEY-1

Zheng, Yuan Wang. Data curation: Xiaoyu Wang, Xiangming Xie, Huiying Luo. Formal analysis: Xiaoyu Wang, Fei Zheng, Tao Tu. Funding acquisition: Bin Yao, Huiying Luo. Methodology: Xiaoyu Wang, Shuai You ... Agriculture Research System (no. CARS-42). We would like to thank LetPub for providing linguistic assistance during the preparation of this manuscript. Author Contributions Conceptualization: Xiaoyu Wang, Fei

Genetic mapping of QTL for maize leaf width combining RIL and IF2 populations

Conceptualization: Qingchang Meng. Data curation: Ruixiang Liu. Investigation: Fei Zheng. Methodology: Lingjie Kong. Writing ± original draft: Ruixiang Liu. Writing ± review & editing: Jianhua Yuan, Thomas

Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury

Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated the value of the PLR in predicting the outcomes of critically ill patients with AKI...

Plasma metabolomics profiles in rats with acute traumatic brain injury

Cui. Software: Yi-Fu Zeng. Supervision: Jie-Kun Luo, Peng Sun, Han-Jin Cui. Validation: Han-Jin Cui. Visualization: Jie-Kun Luo, Peng Sun. Writing ± original draft: Fei Zheng. Writing ± review

Choroidal thickness in school children: The Gobi Desert Children Eye Study

Purpose To investigate choroidal thickness (CT) and its associations in children in a school-based study. Methods The cross-sectional school-based Gobi Desert Children Eye Study included 1565 out of 1911 (81.9%) eligible children from all schools in the oasis region of Ejina in the Gobi Desert. A detailed ophthalmic examination was performed, including spectral-domain optical...

Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

A review of studies on the body fluid levels of neuroactive amino acids, including glutamate, glutamine, taurine, gamma-aminobutyric acid (GABA), glycine, tryptophan, d-serine, and others, in autism spectrum disorders (ASD) is given. The results reported in the literature are generally inconclusive and contradictory, but there has been considerable variation among the previous...

Dual effects of VEGF-B on activating cardiomyocytes and cardiac stem cells to protect the heart against short- and long-term ischemia–reperfusion injury

Aims To investigate whether vascular endothelial growth factor B (VEGF-B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia–reperfusion (I/R) heart and promotes CSC mobilization and angiogenesis. Methods and results One hour after myocardial ischemia and infarction, rats were treated with recombinant human VEGF-B protein following 24 h or 7 days of...

Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice

Autism spectrum disorders (ASDs) are a group of neurodevelopmental afflictions characterized by repetitive behaviors, deficits in social interaction, and impaired communication skills. For most ASD patients, the underlying causes are unknown. Genetic mutations have been identified in about 25 percent of ASD cases, including mutations in epigenetic regulators, suggesting that...

PEP-1-SOD1 fusion proteins block cardiac myofibroblast activation and angiotensin II-induced collagen production

Background Oxidative stress is closely associated with cardiac fibrosis. However, the effect of copper, zinc-superoxide dismutase (SOD1) as a therapeutic agent is limited due to the insufficient transduction. This study was aimed to investigate the effect of PEP-1-SOD1 fusion protein on angiotensin II (ANG II)-induced collagen metabolism in rat cardiac myofibroblasts (MCFs...

Protective effect of L-carnitine in cyclophosphamide-induced germ cell apoptosis

. Based on our results, further human and animal studies are needed to give clearer evidence of L-carnitine in relation to male infertility. Compliance with ethics guidelines Bin ZHU, Yan-fei ZHENG, Yue

Intracameral Interleukin 1β, 6, 8, 10, 12p, Tumor Necrosis Factor α and Vascular Endothelial Growth Factor and Axial Length in Patients with Cataract

Objective To assess associations between the aqueous humour concentration of interleukin IL-1β, IL-6, IL-8, IL-10 and IL-12p, tumor necrosis factor α (TNF-α) and vascular endothelial growth factor (VEGF) and axial length in eyes with cataract. Methods The hospital-based investigation included patients who underwent cataract surgery between March 2014 and April 2014. Using aqueous...

Function of Ca2+-/calmodulin-dependent protein kinase IV in Ca2+-stimulated neuronal signaling and behavior

The activity of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) is sensitive to activity-dependent changes in the level of intracellular Ca2+. Following neuronal stimulation, the activation of CaMKIV may trigger synaptic modifications and transcriptional responses, both of which are involved in regulating cognitive and emotional behavior. Here, we used CaMKIV knockout (KO...

Application of a Novel Alkali-Tolerant Thermostable DyP-Type Peroxidase from Saccharomonospora viridis DSM 43017 in Biobleaching of Eucalyptus Kraft Pulp

Saccharomonospora viridis is a thermophilic actinomycete that may have biotechnological applications because of its dye decolorizing activity, though the enzymatic oxidative system responsible for this activity remains elusive. Bioinformatic analysis revealed a DyP-type peroxidase gene in the genome of S. viridis DSM 43017 with sequence similarity to peroxidase from dye...

miR-34a Inhibits Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting MMP9 and MMP14

Background miR-34a is an important tumor suppressor gene in various cancer types. But little is known about the dysregulation of miR-34a in tongue squamous cell carcinoma (TSCC). In this study, we investigate the expression and potential role of miR-34a in TSCC. Methods We evaluated miR-34a expression and its relationship with clinicopathological characters in 75 pairs of TSCC...

Relationship between toll-like receptor 4 levels in aorta and severity of atherosclerosis

Objective To investigate the relationship between levels of toll-like receptor 4 (TLR4) protein in aortic tissue and the severity of atherosclerosis in patients undergoing coronary artery bypass graft (CABG) surgery.

3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging

Background The treatment of microcirculatory impairment will have great impact if it can be applied to myocardial infarction (MI) patients. The problem is how to study these tiny structures and microphenomenon in heart. Methods We investigated the visualization of cardiac microvessels embolization by the mean of X-ray phase contrast imaging (XPCI), which is a recently emerged...

Analysis of miRNAs and Their Targets during Adventitious Shoot Organogenesis of Acacia crassicarpa

Organogenesis is an important process for plant regeneration by tissue or cell mass differentiation to regenerate a complete plant. MicroRNAs (miRNAs) play an essential role in regulating plant development by mediating target genes at transcriptional and post-transcriptional levels, but the diversity of miRNAs and their potential roles in organogenesis of Acacia crassicarpa have...

Engineering the Expression and Characterization of Two Novel Laccase Isoenzymes from Coprinus comatus in Pichia pastoris by Fusing an Additional Ten Amino Acids Tag at N-Terminus

The detail understanding of physiological/biochemical characteristics of individual laccase isoenzymes in fungi is necessary for fundamental and application purposes, but our knowledge is still limited for most of fungi due to difficult to express laccases heterologously. In this study, two novel laccase genes, named lac3 and lac4, encoding proteins of 547 and 532-amino acids...