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Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

A review of studies on the body fluid levels of neuroactive amino acids, including glutamate, glutamine, taurine, gamma-aminobutyric acid (GABA), glycine, tryptophan, d-serine, and others, in autism spectrum disorders (ASD) is given. The results reported in the literature are generally inconclusive and contradictory, but there has been considerable variation among the previous...

PEP-1-SOD1 fusion proteins block cardiac myofibroblast activation and angiotensin II-induced collagen production

Background Oxidative stress is closely associated with cardiac fibrosis. However, the effect of copper, zinc-superoxide dismutase (SOD1) as a therapeutic agent is limited due to the insufficient transduction. This study was aimed to investigate the effect of PEP-1-SOD1 fusion protein on angiotensin II (ANG II)-induced collagen metabolism in rat cardiac myofibroblasts (MCFs...

3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging

Background The treatment of microcirculatory impairment will have great impact if it can be applied to myocardial infarction (MI) patients. The problem is how to study these tiny structures and microphenomenon in heart. Methods We investigated the visualization of cardiac microvessels embolization by the mean of X-ray phase contrast imaging (XPCI), which is a recently emerged...

Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury

Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated the value of the PLR in predicting the outcomes of critically ill patients with AKI...

Relationship between toll-like receptor 4 levels in aorta and severity of atherosclerosis

Objective To investigate the relationship between levels of toll-like receptor 4 (TLR4) protein in aortic tissue and the severity of atherosclerosis in patients undergoing coronary artery bypass graft (CABG) surgery.

Dual effects of VEGF-B on activating cardiomyocytes and cardiac stem cells to protect the heart against short- and long-term ischemia–reperfusion injury

Aims To investigate whether vascular endothelial growth factor B (VEGF-B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia–reperfusion (I/R) heart and promotes CSC mobilization and angiogenesis. Methods and results One hour after myocardial ischemia and infarction, rats were treated with recombinant human VEGF-B protein following 24 h or 7 days of...

PEP-1-CAT protects hypoxia/reoxygenation-induced cardiomyocyte apoptosis through multiple sigaling pathways

Background Catalase (CAT) breaks down H2O2 into H2O and O2 to protects cells from oxidative damage. However, its translational potential is limited because exogenous CAT cannot enter living cells automatically. This study is aimed to investigate if PEP-1-CAT fusion protein can effectively protect cardiomyocytes from oxidative stress due to hypoxia/reoxygenation (H/R)-induced...

The combined transduction of copper, zinc-superoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury

Background Our previous studies indicate that either PEP-1-superoxide dismutase 1 (SOD1) or PEP-1-catalase (CAT) fusion proteins protects myocardium from ischemia-reperfusion-induced injury in rats. The aim of this study is to explore whether combined use of PEP-1-SOD1 and PEP-1-CAT enhances their protective effects. Methods SOD1, PEP-1-SOD1, CAT or PEP-1-CAT fusion proteins were...

Protective effect of L-carnitine in cyclophosphamide-induced germ cell apoptosis

. Based on our results, further human and animal studies are needed to give clearer evidence of L-carnitine in relation to male infertility. Compliance with ethics guidelines Bin ZHU, Yan-fei ZHENG, Yue

Subsumption resolution: an efficient and effective technique for semi-naive Bayesian learning

Fei Zheng Geoffrey I. Webb Pramuditha Suraweera Liguang Zhu Editors: Mark Craven and Johannes Frnkranz. Semi-naive Bayesian techniques seek to improve the accuracy of naive Bayes (NB) by relaxing

Learning by extrapolation from marginal to full-multivariate probability distributions: decreasingly naive Bayesian classification

Averaged n-Dependence Estimators (AnDE) is an approach to probabilistic classification learning that learns by extrapolation from marginal to full-multivariate probability distributions. It utilizes a single parameter that transforms the approach between a low-variance high-bias learner (Naive Bayes) and a high-variance low-bias learner with Bayes optimal asymptotic error. It...

Adenovirus-mediated stromal cell-derived factor-1 alpha gene transfer improves cardiac structure and function after experimental myocardial infarction through angiogenic and antifibrotic actions

Stromal cell-derived factor 1α (SDF-1) is not only a major chemotactic factor, but also an inducer of angiogenesis. The effects of SDF-1α on the left ventricular remodeling in a rat myocardial infarction (MI) model were analyzed. Myocardial infarction was induced by ligation of the left coronary artery in rats. 0.5 × 1010 pfu/ml AdV-SDF-1 or 0.5 × 1010 pfu/ml Adv-LacZ were...

Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway

The transforming growth factor-β (TGF-β) signalling pathway participates in various biological processes. Dysregulation of Smad4, a central cellular transducer of TGF-β signalling, is implicated in a wide range of human diseases and developmental disorders. However, the mechanisms underlying Smad4 dysregulation are not fully understood. Using a functional screening approach based...

Injectable silicone rubber for ocular implantation after evisceration

. Ethical approval form. (PDF) Author Contributions Data curation: Peng Fei Zheng, Hong Yan Deng. Formal analysis: Peng Fei Zheng. Funding acquisition: Qi Sheng You, Xiao Yan Peng. Investigation: Hong ... : Qi Sheng You. Conceptualization: Peng Fei Zheng, Qian Li, Hong Yan Deng, Xiao Yan Peng. Writing ± review & editing: Qi Sheng You, Ian Y. H. Wong, Xiao Yan Peng. 9 / 10 1. Perman KI , Baylis HI

Improvement of the catalytic efficiency of a hyperthermophilic xylanase from Bispora sp. MEY-1

Zheng, Yuan Wang. Data curation: Xiaoyu Wang, Xiangming Xie, Huiying Luo. Formal analysis: Xiaoyu Wang, Fei Zheng, Tao Tu. Funding acquisition: Bin Yao, Huiying Luo. Methodology: Xiaoyu Wang, Shuai You ... Agriculture Research System (no. CARS-42). We would like to thank LetPub for providing linguistic assistance during the preparation of this manuscript. Author Contributions Conceptualization: Xiaoyu Wang, Fei

Genetic mapping of QTL for maize leaf width combining RIL and IF2 populations

Conceptualization: Qingchang Meng. Data curation: Ruixiang Liu. Investigation: Fei Zheng. Methodology: Lingjie Kong. Writing ± original draft: Ruixiang Liu. Writing ± review & editing: Jianhua Yuan, Thomas

Plasma metabolomics profiles in rats with acute traumatic brain injury

Cui. Software: Yi-Fu Zeng. Supervision: Jie-Kun Luo, Peng Sun, Han-Jin Cui. Validation: Han-Jin Cui. Visualization: Jie-Kun Luo, Peng Sun. Writing ± original draft: Fei Zheng. Writing ± review

Choroidal thickness in school children: The Gobi Desert Children Eye Study

Purpose To investigate choroidal thickness (CT) and its associations in children in a school-based study. Methods The cross-sectional school-based Gobi Desert Children Eye Study included 1565 out of 1911 (81.9%) eligible children from all schools in the oasis region of Ejina in the Gobi Desert. A detailed ophthalmic examination was performed, including spectral-domain optical...

PEP-1-CAT-Transduced Mesenchymal Stem Cells Acquire an Enhanced Viability and Promote Ischemia-Induced Angiogenesis

Objective Poor survival of mesenchymal stem cells (MSC) compromised the efficacy of stem cell therapy for ischemic diseases. The aim of this study is to investigate the role of PEP-1-CAT transduction in MSC survival and its effect on ischemia-induced angiogenesis. Methods MSC apoptosis was evaluated by DAPI staining and quantified by Annexin V and PI double staining and Flow...

Regulation of Brain-Derived Neurotrophic Factor Exon IV Transcription through Calcium Responsive Elements in Cortical Neurons

Activity-dependent transcription of brain-derived neurotrophic factor (BDNF) has been studied as an important model to elucidate the mechanisms underlying numerous aspects of neuroplasticity. It has been extensively emphasized that Ca2+ influx through different routes may have significantly different effects on BDNF transcription. Here, we examined the regulatory property of the...