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11 papers found.
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LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

Samaniego 0 0 Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center , 1515 Holcombe Blvd., Houston, TX 77030 , USA 1 Department of Internal Medicine, Lankenau Medical Center

The risk of central nervous system relapses in patients with peripheral T-cell lymphoma

. Hagemeister, Luis E. Fayad, Jorge E. Romaguera, Felipe Samaniego, Francesco Turturro, Hun J. Lee, Sattva S. Neelapu, M. Alma Rodriguez, Michael Wang, Nathan H. Fowler, L. Jeffrey Medeiros. Supervision ... , Fredrick B. Hagemeister, Luis E. Fayad, Jorge E. Romaguera, Felipe Samaniego, Francesco Turturro, Hun J. Lee, Sattva S. Neelapu, M. Alma Rodriguez, Michael Wang, Nathan H. Fowler, Richard E. Davis, L

Inhibition of Methyltransferases Accelerates Degradation of cFLIP and Sensitizes B-Cell Lymphoma Cells to TRAIL-Induced Apoptosis

Non-Hodgkin lymphomas (NHLs) are characterized by specific abnormalities that alter cell cycle regulation, DNA damage response, and apoptotic signaling. It is believed that cancer cells are particularly sensitive to cell death induced by tumor necrosis factor α–related apoptosis-inducing ligand (TRAIL). However, many cancer cells show blocked TRAIL signaling due to up-regulated...

Targeting Wnt pathway in mantle cell lymphoma-initiating cells

Background Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin’s lymphoma. Despite initial intense chemotherapy, up to 50 % of cases of MCL relapse often in a chemoresistant form. We hypothesized that the recently identified MCL-initiating cells (MCL-ICs) are the main reason for relapse and chemoresistance of MCL. Cancer stem cell-related pathways such...

CD74 interferes with the expression of fas receptor on the surface of lymphoma cells

Background Resistance to Fas-mediated apoptosis limits the efficacy of currently available chemotherapy regimens. We identified CD74, which is known to be overexpressed in hematological malignancies, as one of the factors interfering with Fas-mediated apoptosis. Methods CD74 expression was suppressed in human B-lymphoma cell lines, BJAB and Raji, by either transduction with...

The peptide derived from the Ig-like domain of human herpesvirus 8 K1 protein induces death in hematological cancer cells

BackgroundAlthough significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas signaling, which remains poorly understood. We previously reported that cells expressing the K1 protein of human herpesvirus 8 (HHV-8) resist death through the complex formation of the Ig-like domain of K1 with Fas...

Mechanism of Fas Signaling Regulation by Human Herpesvirus 8 K1 Oncoprotein

Background Herpesvirus 8 (HHV-8) oncoprotein K1 is linked to lymphoproliferation and suppression of apoptosis mediated by the Fas death receptor. Expression of K1 in transgenic mice induces accumulation of lymphoid tissue cells and lymphoma.

14-3-3γ-mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo

Borde Amol S. Hosing Milind M. Vaidya Rahul Thorat Felipe Samaniego Ullas Kolthur-Seetharam Sorab N. Dalal () The regulation of cell-cell adhesion is important for the processes of tissue formation and

Tumorigenesis and Aberrant Signaling in Transgenic Mice Expressing the Human Herpesvirus-8 K1 Gene

Background: The K1 gene of human herpesvirus-8 (HHV-8; also known as Kaposi's sarcoma-associated herpesvirus) encodes a transmembrane signaling protein that elicits cellular activation events. To evaluate the potential role of K1 in HHV-8-associated pathogenesis, we produced transgenic mice expressing the HHV-8 K1 gene under the transcriptional control of the simian virus 40...

Human Kaposi's Sarcoma Cell-Mediated Tumorigenesis in Human Immunodeficiency Type 1 Tat-Expressing Transgenic Mice

Background: The human immunodeficiency virus type 1 (HIV-1) transactivator (Tat) protein has been linked to the development and course of Kaposi's sarcoma (KS) associated with acquired immunodeficiency disease syndrome (AIDS–KS). Tat is an 86–101 amino-acid protein encoded by two exons. To evaluate the growth-promoting effects of Tat in AIDS–KS in vivo, we developed transgenic...

Induction of Programmed Cell Death in Kaposi's Sarcoma Cells by Preparations of Human Chorionic Gonadotropin

BACKGROUND: Isolation of the first neoplastic acquired immunodeficiency syndrome-related Kaposi's sarcoma (KS) cell line (KS Y-1) has furthered understanding of the pathogenesis of KS. Studies with KS Y-1 cells have indicated that inhibition of KS cell proliferation occurs in early pregnancy in mice and after treatment with certain commercial preparations of human chorionic...