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Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1α dependent pathway

(Xiaojing Liu), No. 30871118, 30971325 (Fengming Luo), the projects of Science and Technology Bureau of Sichuan Province No.2008FZ0156 (Hua Fu), No. 2009FZ0097 (Li Yang), the project of Science and Technology ... Bureau of Chengdu No. 2008-10(Hua Fu) and grants from Ministry of Education of the peoples Republic of China, No. NCET-08-0374, 20091001-9-3 (Fengming Luo). We would like to acknowledge the assistance and

Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells

, No. 30870596 (Xiaojing Liu), No. 30700149(Yingqiang Guo), No.30500222, No. 30871118 and No. 30971325 (Fengming Luo). We would like to acknowledge the assistance and critical advice provided by Dr. Jue

High glucose upregulates connective tissue growth factor expression in human vascular smooth muscle cells

Background Connective tissue growth factor (CTGF) is a potent profibrotic factor, which is implicated in fibroblast proliferation, angiogenesis and extracellular matrix (ECM) synthesis. It is a downstream mediator of some of the effects of transforming growth factor β (TGFβ) and is potentially induced by hyperglycemia in human renal mesangial cells. However, whether high glucose...

Melatonin promoted chemotaxins expression in lung epithelial cell stimulated with TNF-α

Background Patients with asthma demonstrate circadian variations in the airway inflammation and lung function. Pinealectomy reduces the total inflammatory cell number in the asthmatic rat lung. We hypothesize that melatonin, a circadian rhythm regulator, may modulate the circadian inflammatory variations in asthma by stimulating the chemotaxins expression in the lung epithelial...

Hypoxia-inducible transcription factor-1α promotes hypoxia-induced A549 apoptosis via a mechanism that involves the glycolysis pathway

Luo), from Research Foundation of Science and Technology Bureau of Sichuan Province, No.04GY029-0831(Fengming Luo) and from Research Foundation of West China Hospital of Sichuan University, No.02951181 ... (Fengming Luo).