curation: L´ıvia C. Ferreira, Francesca Orso, Je´ssica Z. Lacerda, Thaiz F. Borin. Funding acquisition: Thaiz F. Borin. Methodology: L´ıvia C. Ferreira, Francesca Orso, Daniela Dettori, Je´ssica Z. Lacerda ... , Daniela Taverna. Supervision: Daniela Dettori, Daniela Taverna. Validation: L´ıvia C. Ferreira, Francesca Orso. Visualization: Daniela Taverna. Writing – original draft: L´ıvia C. Ferreira. Writing
Background Biological research increasingly relies on network models to study complex phenomena. Signal Transduction Pathways are molecular circuits that model how cells receive, process, and respond to information from the environment providing snapshots of the overall cell dynamics. Most of the attempts to reconstruct signal transduction pathways are limited to single regulator...
Accademia Albertina, 13, Torino, 10123, ItalyFrancesca Orso & Daniela Taverna AuthorsSearch for Gianfranco Politano in:PubMed • Google Scholar Search for Francesca Orso in:PubMed • Google Scholar Search for
ErbB2 overexpression is detected in approximately 20% of breast cancers and is correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of ErbB2 transformation and that its overexpression confers invasive properties to ErbB2-positive human mammary epithelial cells. We herein prove, for the first time, that the...
Francesca Orso 0 Davide Cor Benedetta Ubezio 0 Paolo Provero Michele Caselle Daniela Taverna 0 0 Molecular Biotechnology Center (MBC) and Department of Oncological Sciences, University of Torino
MicroRNAs are single-stranded non-coding RNAs that simultaneously down-modulate the expression of multiple genes post-transcriptionally by binding to the 3′UTRs of target mRNAs. Here we used computational methods to predict microRNAs relevant in breast cancer progression. Specifically, we applied different microRNA target prediction algorithms to various groups of differentially...
Background Neuronal migration is a crucial process that allows neurons to reach their correct target location to allow the nervous system to function properly. AP-2α is a transcription factor essential for neural crest cell migration and its mutation results in apoptosis within this cell population, as demonstrated by genetic models. Results We down-modulated AP-2α expression in...
Background Activator Protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis and have also been implicated in carcinogenesis. Expression of the family members AP-2α and AP-2γ is particularly well documented in malignancies of the female breast. Despite increasing evaluation...
Science, National University of Ireland, Galway, IrelandRichard Jäger AuthorsSearch for Verena Thewes in:PubMed • Google Scholar Search for Francesca Orso in:PubMed • Google Scholar Search for Richard ... , writing and revision. All authors read and approved the final manuscript. Verena Thewes, Francesca Orso contributed equally to this work. Electronic supplementary material Additional file 1: Table
Neuronal migration is a crucial process that allows neurons to reach their correct target location to allow the nervous system to function properly. AP-2α is a transcription factor essential for neural crest cell migration and its mutation results in apoptosis within this cell population, as demonstrated by genetic models. We down-modulated AP-2α expression in GN-11 neurons by...
Introduction Intrinsic plasticity of breast carcinoma cells allows them to undergo a transient and reversible conversion into mesenchymal cells to disseminate into distant organs, where they can re-differentiate to an epithelial-like status to form a cohesive secondary mass. The p130Cas scaffold protein is overexpressed in human ER+ and HER2+ breast cancer where it contributes to...
Biotechnology and Health Sciences, University of Torino, Via Nizza 52, Torino, 10126, ItalyBrigitte Bisaro, Francesca Orso, Annalisa Camporeale, Shana M Colombo, Paola Di Stefano, Giusy Tornillo, Maria P Camacho ... • Google Scholar Search for Manuela Iezzi in:PubMed • Google Scholar Search for Mirco Galiè in:PubMed • Google Scholar Search for Francesca Orso in:PubMed • Google Scholar Search for Annalisa Camporeale
