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Search: authors:"Francesco Nappo"

6 papers found.
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Cytokine Milieu Tends Toward Inflammation in Type 2 Diabetes

ESPOSITO, MD FRANCESCO NAPPO, MD, PHD FRANCESCO GIUGLIANO CARMEN DI PALO MYRIAM CIOTOLA MICHELANGELA BARBIERI, MD GIUSEPPE PAOLISSO, MD DARIO GIUGLIANO, MD, PHD

Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat

This study investigated coronary perfusion pressure, nitric oxide (NO) and superoxide production, nitrotyrosine (NT) formation, and cardiac cell apoptosis in isolated hearts perfused with high glucose concentration. Coronary perfusion pressure; NO and superoxide anion generation; immunostaining for NT, inducible NO synthase (iNOS), and the constitutive type of NO synthase (NOS...

Absence of Inducible Nitric Oxide Synthase Reduces Myocardial Damage During Ischemia Reperfusion in Streptozotocin-Induced Hyperglycemic Mice

We investigated the role of inducible nitric oxide synthase (iNOS) on ischemic myocardial damage and angiogenic process in genetically deficient iNOS (iNOS−/−) mice and wild-type littermates (iNOS+/+), with and without streptozotocin-induced (70 mg/kg intravenously) diabetes. After ischemia (25 min) and reperfusion (120 min), both iNOS+/+ and iNOS−/− diabetic mice (blood glucose...

Expression of Angiogenic Factors During Acute Coronary Syndromes in Human Type 2 Diabetes

Inadequate angiogenic response to ischemia in diabetic myocardium could result in poor collateral formation. Because hypoxia-inducible factor (HIF)-1α is a transcriptional activator of vascular endothelial growth factor (VEGF) and is critical for initiating angiogenic responses to hypoxia, we investigated the expression of HIF-1α and VEGF in specimens of human heart tissue to...

Effects of Stress Hyperglycemia on Acute Myocardial Infarction: Role of inflammatory immune process in functional cardiac outcome

OBJECTIVE—Stress hyperglycemia has been associated with increased mortality in patients with myocardial infarction (MI). We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI. RESEARCH DESIGN AND METHODS—Echocardiographic parameters, circulating levels of interleukin...