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Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways

Multiple myeloma (MM) is a malignant tumor of transformed plasma cells. MM pathogenesis is a multistep process. This cancer can occur de novo (rarely) or it can develop from monoclonal gammopathy of undetermined significance (most of the cases). MM can be asymptomatic (smoldering myeloma) or clinically active. Malignant plasma cells exploit intrinsic and extrinsic bone marrow...

Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces

In this paper we introduce a fully flexible coarse-grained model of immunoglobulin G (IgG) antibodies parametrized directly on cryo-EM data and simulate the binding dynamics of many IgGs to antigens adsorbed on a surface at increasing densities. Moreover, we work out a theoretical model that allows to explain all the features observed in the simulations. Our combined...

Adaptive Linear Prediction Filtering in DWT Domain for Real-Time Musical Onset Detection

Francesco Piazza 0 Stefano Squartini 0 Federico Fontana 0 3MediaLabs, Department of Bioengineering, Electronics and Telecommunications, Universita` Politecnica delle Marche , 60121 Ancona , Italy Onset

Stereophonic hands-free communication system based on microphone array fixed beamforming: real-time implementation and evaluation

In this article, the authors propose an optimally designed fixed beamformer (BF) for stereophonic acoustic echo cancelation (SAEC) in real hands-free communication applications. Several contributions related to the combination of beamforming and echo cancelation have appeared in the literature so far, but, up to the authors’ knowledge, the idea of using optimal fixed BFs in a...

Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

Background The involvement of protein kinase CK2 in sustaining cancer cell survival could have implications also in the resistance to conventional and unconventional therapies. Moreover, CK2 role in blood tumors is rapidly emerging and this kinase has been recognized as a potential therapeutic target. Phase I clinical trials with the oral small ATP-competitive CK2 inhibitor CX...

Protein Kinase CK2 Inhibition Down Modulates the NF-κB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells

Padova ( grant nu CPDA114940/11 "Progetti di Ricerca di Ateneo" to Francesco Piazza and from the Associazione Italiana per la Ricerca sul Cancro (A.I.R.C., Milan; to Gianpietro

Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death

Background Glycogen Synthase Kinase-3 (GSK-3) α and β are two serine-threonine kinases controlling insulin, Wnt/β-catenin, NF-κB signaling and other cancer-associated transduction pathways. Recent evidence suggests that GSK-3 could function as growth-promoting kinases, especially in malignant cells. In this study, we have investigated GSK-3α and GSK-3β function in multiple...

Bottleneck Genes and Community Structure in the Cell Cycle Network of S. pombe

The identification of cell cycle–related genes is still a difficult task, even for organisms with relatively few genes such as the fission yeast. Several gene expression studies have been published on S. pombe showing similarities but also discrepancies in their results. We introduce a network in which the weight of each link is a function of the phase difference between the...