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Search: authors:"Franziska Hartung"

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Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin

Resisting cell death is one of the hallmarks of cancer, and represents a common problem resulting in ineffective cancer therapy. To overcome resistance to apoptosis, we designed an antibody-based therapy strategy using Kv10.1 as a target. Kv10.1 is a voltage-gated potassium channel, which has been identified as a tumor marker several years ago. The agent consists of a ...

Taking Perspective: Personal Pronouns Affect Experiential Aspects of Literary Reading

Personal pronouns have been shown to influence cognitive perspective taking during comprehension. Studies using single sentences found that 3rd person pronouns facilitate the construction of a mental model from an observer’s perspective, whereas 2nd person pronouns support an actor’s perspective. The direction of the effect for 1st person pronouns seems to depend on the situational ...

In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1

The Kv10.1 (Eag1) voltage-gated potassium channel represents a promising molecular target for novel cancer therapies or diagnostic purposes. Physiologically, it is only expressed in the brain, but it was found overexpressed in more than 70 % of tumours of diverse origin. Furthermore, as a plasma membrane protein, it is easily accessible to extracellular interventions. In this study ...

Tumor cell-selective apoptosis induction through targeting of KV10.1 via bifunctional TRAIL antibody

Franziska Hartung 0 Walter Sthmer 0 Luis A Pardo 0 0 Max-Planck-Institut fur experimentelle Medizin , Hermann-Rein-Str. 3, 37075 Gottingen , Germany Background: The search for strategies to target