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Search: authors:"Franziska Hartung"

3 papers found.
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Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin

Resisting cell death is one of the hallmarks of cancer, and represents a common problem resulting in ineffective cancer therapy. To overcome resistance to apoptosis, we designed an antibody-based therapy strategy using Kv10.1 as a target. Kv10.1 is a voltage-gated potassium channel, which has been identified as a tumor marker several years ago. The agent consists of a ...

In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1

The Kv10.1 (Eag1) voltage-gated potassium channel represents a promising molecular target for novel cancer therapies or diagnostic purposes. Physiologically, it is only expressed in the brain, but it was found overexpressed in more than 70 % of tumours of diverse origin. Furthermore, as a plasma membrane protein, it is easily accessible to extracellular interventions. In this study ...

Tumor cell-selective apoptosis induction through targeting of KV10.1 via bifunctional TRAIL antibody

Franziska Hartung 0 Walter Sthmer 0 Luis A Pardo 0 0 Max-Planck-Institut fur experimentelle Medizin , Hermann-Rein-Str. 3, 37075 Gottingen , Germany Background: The search for strategies to target