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54 papers found.
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A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

Scheltens 8 Frederik Barkhof 6 7 8 Tania Nikolcheva 6 Elizabeth Ashford 5 Sylvie Retout 9 Carsten Hofmann 9 Paul Delmar 0 Gregory Klein 6 Mirjana Andjelkovic 9 Bruno Dubois 3 Mercè Boada 11 Kaj Blennow 12

Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment

Background Amyloid pathology in subjects with mild cognitive impairment (MCI) is an important risk factor for progression to dementia due to Alzheimer’s disease. Predicting the onset of dementia is challenging even in the presence of amyloid, as time to progression varies considerably among patients and depends on the onset of neurodegeneration. Survival analysis can account for...

The value of subtraction MRI in detection of amyloid-related imaging abnormalities with oedema or effusion in Alzheimer’s patients: An interobserver study

that this work has not received any funding. Compliance with ethical standards Guarantor The scientific guarantor of this publication is Prof. Frederik Barkhof. Conflict of interest The authors of this ... manuscript declare relationships with the following companies: Dr. Frederik Barkhof acts a consultant for Janssen Alzheimer Immunotherapy Research & Development, LLC and H. Michael Arrighi together with H

Regional analysis of volumes and reproducibilities of automatic and manual hippocampal segmentations

Purpose Precise and reproducible hippocampus outlining is important to quantify hippocampal atrophy caused by neurodegenerative diseases and to spare the hippocampus in whole brain radiation therapy when performing prophylactic cranial irradiation or treating brain metastases. This study aimed to quantify systematic differences between methods by comparing regional volume and...

Brain reward responses to food stimuli among female monozygotic twins discordant for BMI

Obese individuals are characterized by altered brain reward responses to food. Despite the latest discovery of obesity-associated genes, the contribution of environmental and genetic factors to brain reward responsiveness to food remains largely unclear. Sixteen female monozygotic twin pairs with a mean BMI discordance of 3.96 ± 2.1 kg/m2 were selected from the Netherlands Twin...

Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET

Objective Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This...

Making better use of our brain MRI research data

Frederik Barkhof 0 ) Department of Radiology, VU University Medical Center , Amsterdam, The Netherlands - Increasingly, MRI is used outside the diagnostic setting to study brain physiology, or the

Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer’s disease

Objective To determine whether lower cerebral blood flow (CBF) is associated with faster cognitive decline in patients with Alzheimer’s disease (AD). Methods We included 88 patients with dementia due to AD from the Amsterdam Dementia Cohort. Mean follow-up was 2 ± 1 years. Linear mixed models were used to determine associations of lower whole brain and regional pseudo-continuous...

Alterations in white matter volume and integrity in obesity and type 2 diabetes

Type 2 diabetes mellitus (T2DM) is characterized by obesity, hyperglycemia and insulin resistance. Both T2DM and obesity are associated with cerebral complications, including an increased risk of cognitive impairment and dementia, however the underlying mechanisms are largely unknown. In the current study, we aimed to determine the relative contributions of obesity and the...

Liraglutide Reduces CNS Activation in Response to Visual Food Cues Only After Short-term Treatment in Patients With Type 2 Diabetes

OBJECTIVE Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are associated with reduced appetite and body weight. We investigated whether these effects could be mediated by the central nervous system (CNS).

Diagnostic relevance of high field MRI in clinical neuroradiology: the advantages and challenges of driving a sports car

Mike P. Wattjes Frederik Barkhof High field MRI operating at 3 T is increasingly being used in the field of neuroradiology on the grounds that higher magnetic field strength should theoretically

Grey Matter Atrophy in Multiple Sclerosis: Clinical Interpretation Depends on Choice of Analysis Method

Background Studies disagree on the location of grey matter (GM) atrophy in the multiple sclerosis (MS) brain. Aim To examine the consistency between FSL, FreeSurfer, SPM for GM atrophy measurement (for volumes, patient/control discrimination, and correlations with cognition). Materials and Methods 127 MS patients and 50 controls were included and cortical and deep grey matter...

Can MS lesion stages be distinguished with MRI? A postmortem MRI and histopathology study

and Related Disorders, Italian MS society and Finnish Academy. Frederik Barkhof serves on the editorial boards of Brain, European Radiology, Neuroradiology, Multiple Sclerosis journal and Radiology and

Head-to-Head Comparison of Two Popular Cortical Thickness Extraction Algorithms: A Cross-Sectional and Longitudinal Study

Revillard; Baptiste Grenier; University of the West of England: Richard McClatchey; Andrew Branson; Kamran Munir; Jetendr Shamdasani; Saad Liaquat; VU University Medical Center Amsterdam: Frederik Barkhof

Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

Aims/hypothesis The central nervous system (CNS) is a major player in the regulation of food intake. The gut hormone glucagon-like peptide-1 (GLP-1) has been proposed to have an important role in this regulation by relaying information about nutritional status to the CNS. We hypothesised that endogenous GLP-1 has effects on CNS reward and satiety circuits. Methods This was a...

GLP-1 Receptor Activation Modulates Appetite- and Reward-Related Brain Areas in Humans

Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in food intake and body weight. We hypothesized that food intake reduction after GLP-1 receptor activation is...

Cerebral perfusion in the predementia stages of Alzheimer’s disease

3D pseudo-continuous ASL sequence that was used to obtain data for this paper. The scientific guarantor of this publication is Frederik Barkhof. The authors of this manuscript declare relationships

High field MRI in the diagnosis of multiple sclerosis: high field–high yield?

Mike P. Wattjes Frederik Barkhof Following the approval of the U.S. Food and Drug Administration (FDA), high field magnetic resonance imaging (MRI) has been increasingly incorporated into the

The effect of galantamine on brain atrophy rate in subjects with mild cognitive impairment is modified by apolipoprotein E genotype: post-hoc analysis of data from a randomized controlled trial

Introduction The aim of this investigation was to assess the effect of galantamine, an acetylcholinesterase inhibitor and allosteric modulator of nicotinic receptors, on brain atrophy in individuals with mild cognitive impairment (MCI), and to assess effect modification by apolipoprotein E (APOE) genotype. Methods We used data from the Galantamine-International-11 (Gal-Int-11...

Resection Probability Maps for Quality Assessment of Glioma Surgery without Brain Location Bias

Background Intraoperative brain stimulation mapping reduces permanent postoperative deficits and extends tumor removal in resective surgery for glioma patients. Successful functional mapping is assumed to depend on the surgical team's expertise. In this study, glioma resection results are quantified and compared using a novel approach, so-called resection probability maps (RPM...