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The promise of stromal cell-derived factor-1 in novel heart disease treatments

Charité Medical Faculty , Lindenberger Weg 80, 13125 Berlin , Germany 1 Friedrich C. Luft - The stromal cell-derived factor 1 (SDF-1), also known as CX-C motif chemokine 12 (CXCL12), is a chemokine that ... robustness of the hypoxiachampion in the rodent world is the naked mole rat [ 18 ]. Surely, we should scrutinize this model. Respectfully, Friedrich C. Luft 1. Nagasawa T ( 2014 ) CXC chemokine ligand 12

Berlin Wild—and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch

deserves to be retold. Respectfully, Friedrich C. Luft I am taking the liberty of writing a post-script to Friedrich (Fred) Luft’s comment on an important episode in the history of science in Berlin-Buch

The renin-angiotensin system and prolylcarboxypeptidase

degradation of Ang II to Ang (1–7) should be vigorously pursued. Respectfully, Friedrich C. Luft Experimental and Clinical Research Center 13125 Berlin 1. Qaradakhi T , Apostolopoulos V , Zulli A ( 2016

Mesangial renal disease, oxygen sensing, and prolyl hydroxylase

is sufficiently common and severe enough that a rigorous search should be made. As a matter of fact, human biopsy tissue specimens are currently available for analysis [17]. Respectfully Friedrich C ... . Luft 1. Klimova T , Chandel NS ( 2008 ) Mitochondrial complex III regulates hypoxic activation of HIF . Cell Death Differ 15 : 660 - 666 2. Speer RE , Karuppagounder SS , Basso M , Sleiman SF , Kumar A

Mesenchymal stem cells provide novel insights into ankylosing spondylitis

, potential animal models are also available to test the MCP-1 hypothesis. Respectfully, Friedrich C. Luft 1. Taurog JD , Chhabra A , Colbert RA ( 2016 ) Ankylosing spondylitis and axial spondyloarthritis

Could licorice lick inflammasomes?

Weg 80, 13125 Berlin , Germany 1 Friedrich C. Luft Inflammasomes are multiprotein complexes of more than 700 kDa that release cytokines, interleukin-1β (IL-1β), and interferon-γ-inducing interleukin-18 ... must leave some questions unanswered for the next experiments. Respectfully, Friedrich C. Luft 1. Schroder K , Tschopp J ( 2010 ) The inflammasomes . Cell 140 : 821 - 832 2. Franchi L , Munoz-Planillo

Asian flushing presents opportunities for disease prevention

Faculty , Lindenberger Weg 80, 13125 Berlin , Germany 1 Friedrich C. Luft The aldehyde dehydrogenases are a family of detoxifying enzymes that oxidize aldehydes to carboxylic acids. ALDH1 and ALDH2 are the ... C. Luft 1. Chen CH , Ferreira JC , Gross ER , Mochly-Rosen D ( 2014 ) Targeting aldehyde dehydrogenase 2: new therapeutic opportunities . Phys Rev 94 : 1 - 34 2. Dandre F , Cassaigne A , Iron A

NFAT5 moves to Fat City

activation through osmolal mechanisms could conceivably be responsible for the local effects observed by the authors. Respectfully, Friedrich C. Luft 1. Cheung CY , Ko BC ( 2013 ) NFAT5 in cellular

An osteoarthritis triple play

, Berlin 13125 , Germany 1 Friedrich C. Luft - In American baseball, a triple play is the rare act of making three outs during the same continuous play. In this issue of J Mol Med, we feature a triple play ... about angiogenesis. All of these findings are important in unraveling a major, clinically important puzzle. Respectfully, Friedrich C. Luft 1. Goldring MB , Berenbaum F ( 2015 ) Emerging targets in

ATP–ADP translocase and effects on ischemic heart

. Preserved ANT1 activity seems most important to that end. Respectfully, Friedrich C. Luft. 1. Lohmann K ( 1929 ) Über die pyrophosphatfraktion im muskel . Naturwissenschaften 17 : 624 - 625 2. Klumpe ISK

A visionary scientist selects clinicians for clinical research

speak for my clinician/scientist colleagues. Respectfully, Friedrich C. Luft 10. 1. Ganten D , Hayduk K , Brecht HM , Boucher R , Genest J ( 1970 ) Evidence of renin release or production in splanchnic

Hypoxemia as a model for high altitude and cardiovascular risk reduction

, Berlin , Germany 1 Friedrich C. Luft - Is high-altitude living healthy? Perhaps in wealthy Aspen, Colorado. Data from China suggest that the least healthy place to live there is in Tibet [ 1 ]. Of ... -altitude and heart (cardiovascular) disease remains a bit muddled; the current results are interesting nonetheless. Respectfully, Friedrich C. Luft 1. Zhou M , Wang H , Zhu J , Chen W , Wang L , Liu S

High-mobility group box 1 protein, angiotensins, ACE2, and target organ damage

Delbrück Center for Molecular Medicine , Lindenbergerweg 80, 13125 Berlin , Germany 1 Friedrich C. Luft High-mobility group box 1 (HMGB1) protein is an important chromatin protein. In the nucleus, HMGB1

Osteoarthritis is what the people have

area are enormous and the field should be watched with extreme interest! Respectfully, Friedrich C. Luft Fig 1 Entirely speculative notion on how the authors’ findings might work. Panx3 is a

Targeting epithelial–mesenchymal transition

, the role of EMT in these models should be more precisely defined. Respectfully, Friedrich C. Luft 1. Thiery JP , Acloque H , Huang RY , Nieto MA ( 2009 ) Epithelialmesenchymal transitions in

Fitting homocysteine to disease models, as well as adjusting the models to the disease

stubborn, outbred, heterogeneous animal model that has little utility in explaining diseases in rodents. Respectfully, Friedrich C. Luft 1. Dayal S , Lentz SR ( 2008 ) Murine models of

Blood and iron

Friedrich C. Luft 0 0 Experimental and Clinical Research Center, Charite Medical Faculty , Berlin , Germany - Not through speeches and majority decisions will the mechanisms of hemochromatosis be ... in iron homeostasis (Fig. 1). Respectfully, Friedrich C. Luft 1. Helms RA ( 2006 ) Textbook of therapeutics: drug and disease management, 8th edn . Lippincott Williams & Wilkins , United States

Aortic stenosis is largely a boney affair

Friedrich C. Luft 0 ) Experimental and Clinical Research Center, a joint cooperation between the Max-Delbruck Center for Molecular Medicine and the Charite Medical Faculty , Berlin , Germany Aortic