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Regulation of Cellular Metabolism and Cytokines by the Medicinal Herb Feverfew in the Human Monocytic THP-1 Cells

The herb feverfew is a folk remedy for various symptoms including inflammation. Inflammation has recently been implicated in the genesis of many diseases including cancers, atherosclerosis and rheumatoid arthritis. The mechanisms of action of feverfew in the human body are largely unknown. To determine the cellular targets of feverfew extracts, we have utilized oligo microarrays...

A LTS Approach to Control in Event-B

In Event-B, people need to use control variables to constrain the order of events, which is a time-consuming and error-prone process. This paper presents a method of combining labeled transition system and iUML-B to complete the behavior modeling of system, which is more convenient and practical for engineers who are accustomed to using the automaton to build a system behavior...

A LTS Approach to Control in Event-B

In Event-B, people need to use control variables to constrain the order of events, which is a time-consuming and error-prone process. This paper presents a method of combining labeled transition system and iUML-B to complete the behavior modeling of system, which is more convenient and practical for engineers who are accustomed to using the automaton to build a system behavior...

Cost-effectiveness of health care service delivery interventions in low and middle income countries: a systematic review

BackgroundLow and middle income countries (LMICs) face severe resource limitations but the highest burden of disease. There is a growing evidence base on effective and cost-effective interventions for these diseases. However, questions remain about the most cost-effective method of delivery for these interventions. We aimed to review the scope, quality, and findings of economic...

One-year survival rate and healthcare costs after cardiac arrest in Taiwan, 2006–2012

speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/Iz72Yl. Author Contributions Conceptualization: Yi-Ming Weng, Cheng-Yu Chien, Kuan-Fu Chen, Jr-Rung Lin, Chee-Jen ... Chien. Software: Jr-Rung Lin, Chee-Jen Chang. Supervision: Chen-June Seak, Kuan-Fu Chen. Validation: Jr-Rung Lin. Writing ± original draft: Yi-Ming Weng, Cheng-Yu Chien. Writing ± review & editing

Low-intensity pulsed ultrasound improves behavioral and histological outcomes after experimental traumatic brain injury

-Yi Yang AuthorsSearch for Wei-Shen Su in:Nature Research journals • PubMed • Google Scholar Search for Chun-Hu Wu in:Nature Research journals • PubMed • Google Scholar Search for Szu-Fu Chen ... authors declare that they have no competing interests. Corresponding authors Correspondence to Szu-Fu Chen or Feng-Yi Yang. Rights and permissions Open Access This article is licensed under a

Effects of decades of physical driving on body movement and motion sickness during virtual driving

. Stoffregen. Formal analysis: Thomas A. Stoffregen, Chih-Hui Chang. Investigation: Fu-Chen Chen, Wei-Jhong Zeng. Methodology: Thomas A. Stoffregen, Chih-Hui Chang. Supervision: Thomas A. Stoffregen, Chih

HawkRank: a new scoring function for protein–protein docking based on weighted energy terms

Deciphering the structural determinants of protein–protein interactions (PPIs) is essential to gain a deep understanding of many important biological functions in the living cells. Computational approaches for the structural modeling of PPIs, such as protein–protein docking, are quite needed to complement existing experimental techniques. The reliability of a protein–protein...

Detection of Plasma Biomarkers Using Immunomagnetic Reduction: A Promising Method for the Early Diagnosis of Alzheimer’s Disease

also holds MagQu stock. Ming-Jang Chiu and Ta-Fu Chen have nothing to disclose. Compliance with Ethics Guidelines. This article is based on previously conducted studies and does not involve any new

Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage

Inflammatory responses significantly contribute to neuronal damage and poor functional outcomes following intracerebral hemorrhage (ICH). Soluble epoxide hydrolase (sEH) is known to induce neuroinflammatory responses via degradation of anti-inflammatory epoxyeicosatrienoic acids (EET), and sEH is upregulated in response to brain injury. The present study investigated the...

Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage

Inflammatory responses significantly contribute to neuronal damage and poor functional outcomes following intracerebral hemorrhage (ICH). Soluble epoxide hydrolase (sEH) is known to induce neuroinflammatory responses via degradation of anti-inflammatory epoxyeicosatrienoic acids (EET), and sEH is upregulated in response to brain injury. The present study investigated the...

Antioxidant Activity of Quercetin and Its Glucosides from Propolis: A Theoretical Study

AffiliationsCollege of Bee Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, P.R. ChinaYan-Zhen Zheng, Qin Liang, Da-Fu Chen, Rui Guo & Rong-Cai LaiKey Laboratory of Bioorganic Phosphorous Chemistry ... • Google Scholar Search for Geng Deng in:Nature Research journals • PubMed • Google Scholar Search for Qin Liang in:Nature Research journals • PubMed • Google Scholar Search for Da-Fu Chen in:Nature

Sequencing of complete mitochondrial genomes confirms synonymization of Hyalomma asiaticum asiaticum and kozlovi, and advances phylogenetic hypotheses for the Ixodidae

-Feng Liu, Chuang-Fu Chen. Data curation: Zhi-Qiang Liu, Deng-Feng Wang, Jun-Wei Wang, Tao Han, Chen-Feng Shen. Formal analysis: Zhi-Qiang Liu, Li Zhao, Tao Han, Yuan-Zhi Wang. Funding acquisition: Zhi ... Chen, Chuang-Fu Chen. Resources: Zhi-Qiang Liu, Nuer Kuermanali, Chen-Feng Shen. Software: Yan-Feng Liu, Jie Wang. Supervision: Zhuang-Zhi Zhang, Chuang-Fu Chen. Validation: Zhi-Qiang Liu, Jun-Wei

Morphological and molecular divergence of Rhipicephalus turanicus tick from Albania and China

Rhipicephalus turanicus is an important tick species potentially carrying tick-borne pathogens. Several tick species have obvious subspecies divergence. However few studies aimed to examine the existence of divergence within R. turanicus. Therefore, a detailed morphological and molecular analysis was conducted for comparing R. turanicus from the Mediterranean Basin (represented...

Bronchiectasis and increased risk of ischemic stroke: a nationwide population-based cohort study

Bronchiectasis and increased risk of ischemic stroke: a nationwide population-based cohort study Yung-Fu Chen,1–3,* Hsuan-Hung Lin,4,* Chih-Sheng Lin,5 Battsetseg Turbat,1 Kuo-An Wang,4,6 Wei-Sheng

Noninvasive prenatal diagnosis of fetal aneuploidy by circulating fetal nucleated red blood cells and extravillous trophoblasts using silicon-based nanostructured microfluidics

Noninvasive prenatal testing (NIPT) based on cell-free DNA in maternal circulation has been accepted worldwide by the clinical community since 2011 but limitations, such as maternal malignancy and fetoplacental mosaicism, preclude its full replacement of invasive prenatal diagnosis. We present a novel silicon-based nanostructured microfluidics platform named as “Cell Reveal™” to...

Noninvasive prenatal diagnosis of fetal aneuploidy by circulating fetal nucleated red blood cells and extravillous trophoblasts using silicon-based nanostructured microfluidics

Noninvasive prenatal testing (NIPT) based on cell-free DNA in maternal circulation has been accepted worldwide by the clinical community since 2011 but limitations, such as maternal malignancy and fetoplacental mosaicism, preclude its full replacement of invasive prenatal diagnosis. We present a novel silicon-based nanostructured microfluidics platform named as “Cell Reveal™” to...

PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

1R35GM118279. P.L.T.T., C.-F.C. and T.J.P. are supported by fellowships from EMBO, NJCCR, FORD Foundation and Burroughs Wellcome. Author information Author notesThomas J. Pohl & Chi-Fu Chen These authors ... contributed equally to this work. AffiliationsDepartment of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USAPhong Lan Thao Tran, Thomas J. Pohl, Chi-Fu Chen

Comparative analyses of structural features and scaffold diversity for purchasable compound libraries

Large purchasable screening libraries of small molecules afforded by commercial vendors are indispensable sources for virtual screening (VS). Selecting an optimal screening library for a specific VS campaign is quite important to improve the success rates and avoid wasting resources in later experimental phases. Analysis of the structural features and molecular diversity for...

Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases

• Google Scholar Search for Chung-Jung Liu in:Nature Research journals • PubMed • Google Scholar Search for Bi-Chuang Weng in:Nature Research journals • PubMed • Google Scholar Search for Fu-Chen Kuo ... implementing the research protocol, interpreting the data, guiding discussions of the results, and drafting the manuscript. Wen-Hung Hsu, Chung-Jung Liu, Bi-Chuang Weng, Fu-Chen Kuo, Chao-Hung Kuo, were