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17 papers found.
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Targeted disruption of Noc4l leads to preimplantation embryonic lethality in mice

Yan, George Fu Gao, and Xiangdong Li declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed. Yongli Qin1

In vitro assembly of Ebola virus nucleocapsid-like complex expressed in E. coli

Ebola virus (EBOV) harbors an RNA genome encapsidated by nucleoprotein (NP) along with other viral proteins to form a nucleocapsid complex. Previous Cryo-eletron tomography and biochemical studies have shown the helical structure of EBOV nucleocapsid at nanometer resolution and the first 450 amino-acid of NP (NPΔ451–739) alone is capable of forming a helical nucleocapsid-like...

Immunoprotection of recombinant Eg.P29 against Echinococcus granulosus in sheep

Objective This study aims to investigate the immunoprotection of recombinant Eg.P29 (rEg.P29) vaccine and analyze the underlying mechanism in sheep. Methods Three groups of male sheep were immunized subcutaneously with rEg.P29 and PBS, Freund’s complete adjuvant as controls, respectively. After prime-boost vaccination, the sheep were challenged with encapsulated Echinococcus...

Insights into battles between Mycobacterium tuberculosis and macrophages

. COMPLIANCE WITH ETHICS GUIDELINES Guanghua Xu, Jing Wang, George Fu Gao, and Cui Hua Liu declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects

Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity

Protein kinase R (PKR) is a vital component of host innate immunity against viral infection. However, the mechanism underlying inactivation of PKR by influenza A virus (IAV) remains elusive. Here, we found that vault RNAs (vtRNAs) were greatly induced in A549 cells and mouse lungs after infection with IAV. The viral NS1 protein was shown to be the inducer triggering the...

Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China

In China, HIV-1-infected patients typically receive antiretroviral therapy (ART) that includes lamivudine (3TC) as a reverse-transcriptase inhibitor (RTI) (ART-3TC). Previous studies from certain developed countries have shown that, in ART-3TC, 3TC-resistant HBV progressively emerges at an annual rate of 15–20% in patients coinfected with HIV-1 and HBV. This scenario in China...

Duck egg drop syndrome virus: an emerging Tembusu-related flavivirus in China

Duck egg drop syndrome virus (DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China. DEDSV infection mainly results in severe egg drop syndrome in domestic poultry, which leads to huge economic losses. Thus, the discovery of ways and means to combat DEDSV is urgent. Since 2010, a remarkable amount of progress concerning DEDSV research has been achieved...

CpG-Oligodeoxynucleotide Treatment Protects against Ionizing Radiation-Induced Intestine Injury

Background the bone marrow and the intestine are the major sites of ionizing radiation (IR)-induced injury. Our previous study demonstrated that CpG-oligodeoxynucleotide (ODN) treatment mitigated IR-induced bone marrow injury, but its effect on the intestine is not known. In this study, we sought to determine if CpG-ODN have protective effect on IR-induced intestine injury, and...

Radioprotection of Bone Marrow Hematopoiesis by CpG-oligodeoxynucleotides Administered to Mice after Total-body Irradiation

Chao ZHANG Jing LIN Jianguo CUI Bailong LI Cong LIU Jichao WANG Fu GAO Jianming CAI - CpG-ODN/Radioprotection/Hematopoiesis. CpG-oligodeoxynucleotide (ODN), a synthetic analog of bacteria DNA, has

Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase

Since the 2009 pandemic H1N1 swine-origin influenza A virus (09 S-OIV) has reminded the world about the global threat of the ever changing influenza virus, many questions regarding the detailed re-assortment of influenza viruses yet remain unanswered. Influenza A virus is the causative agent of the pandemic flu and contains 2 major antigenic glycoproteins on its surface: (i...

Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability

Protein thermostability is an inherent characteristic of proteins from thermophilic microorganisms, and therefore enables these organisms to survive at extreme temperatures. Although it is well-known that thermostable proteins are critical for the growth of thermophilic organisms, the structural basis of protein thermostability is not yet fully understood. The histidine...

Lab methods / biomarkers

Introduction and Aims:Patients with Chronic Kidney Disease (CKD) and/or Diabetes are at a high risk for cardiovascular (CV) disease. Improved outcomes require a better understanding of specific risk factors that distinctly modulate the incidence of atheromatous disease. Herein. we compared the distinct and combined impact of CKD and of diabetes (DM) on the development of...