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Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

& Salvatore Panico 27 & Alaitz Poveda 28,29 & J. Ramón Quirós 30 & Fulvio Ricceri 31,32 & Ivonne Sluijs 25 & Annemieke M. W. Spijkerman 33 & Anne Tjonneland 34 & Rosario Tumino 35,36 & Anna Winkvist 37

Socioeconomic indicators in epidemiologic research: A practical example from the LIFEPATH study

Raitakari (Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland), Ana Isabel Ribeiro (EPIUnit±Institute of Public Health, University of Porto, Portugal), Fulvio ... Ricceri (Epidemiology Unit, ASL TO3, Piedmont Region, Grugliasco (TO), Italy; Department of Clinical and Biological Science, University of Turin, Italy), Oliver Robinson (Department of Epidemiology and

Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men

. Nomura, Steven E. Oliver, J. Kellogg Parsons, Petra H. Peeters, Elizabeth A. Platz, Elio Riboli, Fulvio Ricceri, Sabina Rinaldi, Harri Rissanen, Norie Sawada, Catherine A. Schaefer, Jeannette M. Schenk ... , Elizabeth A. Platz, Elio Riboli, Fulvio Ricceri, Sabina Rinaldi, Harri Rissanen, Norie Sawada, Catherine A. Schaefer, Jeannette M. Schenk, Frank Z. Stanczyk, Meir Stampfer, PaÈr Stattin, Ulf-Håkan Stenman

The Association between Educational Level and Cardiovascular and Cerebrovascular Diseases within the EPICOR Study: New Evidence for an Old Inequality Problem

Background A consistent association has been reported between low socioeconomic status (SES) and cardiovascular events (CE), whereas the association between SES and cerebrovascular events (CBVD) is less clear. The aim of this study was to investigate the association between SES (measured using education) and CE/CBVD in a cohort study, as well as to investigate lifestyle and...

Dietary Total Antioxidant Capacity and Colorectal Cancer in the Italian EPIC Cohort

Background Colorectal cancer is the third most common cancer worldwide. Diet has been hypothesized as involved in colorectal cancer etiology, but few studies on the influence of total dietary antioxidant intake on colorectal cancer risk have been performed. Methods We investigated the association between colorectal cancer risk and the total antioxidant capacity (TAC) of the diet...

Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

Sieri Amalia Mattiello Rosario Tumino Fulvio Ricceri H. Bas Bueno-de-Mesquita Petra H. M. Peeters Carla H. Van Gils Elisabete Weiderpass Eiliv Lund J. Ramón Quirós Antonio Agudo Maria-José Sánchez María

Seasonality Modifies Methylation Profiles in Healthy People

DNA methylation is a well-characterized epigenetic modification that plays an important role in the regulation of gene expression. There is growing evidence on the involvement of epigenetic mechanisms in disease onset, including cancer. Environmental factors seem to induce changes in DNA methylation affecting human health. However, little is known about basal methylation levels...

Metabolic Syndrome and Breast Cancer Risk: A Case-Cohort Study Nested in a Multicentre Italian Cohort

Background Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, low high-density lipoprotein cholesterol, high blood glucose, and high blood pressure) is emerging as a risk factor for breast cancer; however few studies – most confined to postmenopausal women – have investigated associations between breast cancer risk and metabolic...

454 Pyrosequencing Analysis on Faecal Samples from a Randomized DBPC Trial of Colicky Infants Treated with Lactobacillus reuteri DSM 17938

Objective To analyze the global microbial composition, using large-scale DNA sequencing of 16 S rRNA genes, in faecal samples from colicky infants given L. reuteri DSM 17938 or placebo. Methods Twenty-nine colicky infants (age 10–60 days) were enrolled and randomly assigned to receive either Lactobacillus reuteri (108 cfu) or a placebo once daily for 21 days. Responders were...

Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort

Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. Methods We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR...

Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA...

Validation of the nucleotide excision repair comet assay on cryopreserved PBMCs to measure inter-individual variation in DNA repair capacity

Inter-individual susceptibility to mutagens/carcinogens can be assessed by either genotyping DNA repair genes in different pathways or phenotyping DNA repair capacity (DRC) at the molecular or cellular level. Due to the large number of known DNA repair genes, and the interactions between repair pathways, phenotyping is becoming the preferred approach to measure DRC, and reliable...

Methodological issues in estimating survival in patients with multiple primary cancers: an application to women with breast cancer as a first tumour

responsibility to submit for publication. Acknowledgements This research was partly founded by Regione Piemonte – Ricerca Sanitaria Finalizzata (years 2004 and 2006). Preliminary results were presented by Fulvio ... Ricceri at the GRELL meeting 2006 in Palma de Mallorca awarding the "Enrico Anglesio Prize "offered by the "Anglesio/Moroni Foundation "of Turin, Italy. We thank the researchers and professors of the

Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes

Emily Sonestedt Giovanna Masala Claudia Agnoli Rosario Tumino Annemieke MW Spijkerman Aurelio Barricarte Fulvio Ricceri Saioa Chamosa Ingegerd Johansson Anna Winkvist Anne Tjnneland Diewertje Sluik Heiner

Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking

A single cytosine–guanine dinucleotide (CpG) site within coagulation factor II (thrombin) receptor-like 3 (F2RL3) was recently found to be hypomethylated in peripheral blood genomic DNA from smokers compared with former and non-smokers. We performed two epigenome-wide association studies (EWAS) nested in a prospective healthy cohort using the Illumina 450K Methylation Beadchip...

Telomere Length Variation in Juvenile Acute Myocardial Infarction

Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the predictive value of LTL on the onset of major cardiovascular events, 199 patients...

Dietary Glycemic Load and Glycemic Index and Risk of Cerebrovascular Disease in the EPICOR Cohort

Background Studies on the association of stroke risk to dietary glycemic index (GI) and glycemic load (GL) have produced contrasting results. Objective To investigate the relation of dietary GI and GL to stroke risk in the large EPIC-Italy cohort (EPICOR) recruited from widely dispersed geographic areas of Italy. Design We studied 44099 participants (13,646 men and 30,453 women...

Association Between Total Number of Deaths, Diabetes Mellitus, Incident Cancers, and Haplotypes in Chromosomal Region 8q24 in a Prospective Study

metabolic syndrome, potentially leading to common preventive measures and/or therapies. ACKNOWLEDGMENTS Author affiliations: Human Genetics Foundation, Torino, Italy (Simonetta Guarrera, Fulvio Ricceri ... , Torino, Italy (Fulvio Ricceri, Carlotta Sacerdote, Giuseppe Matullo); Centro di Prevenzione-Piemonte, Torino, Italy (Carlotta Sacerdote); and Medical Research CouncilHealth Protection Agency Centre for

Compliance with clinical practice guidelines for breast cancer treatment: a population-based study of quality-of-care indicators in Italy

Background It has been documented that variations exist in breast cancer treatment despite wide dissemination of clinical practice guidelines. The aim of this population-based study was to evaluate the impact of regional guidelines (Piedmont guidelines, PGL) for breast cancer diagnosis and treatment on quality-of-care indicators in the Northwestern Italian region of Piedmont...

Lifestyle factors and mortality risk in individuals with diabetes mellitus: are the associations different from those in individuals without diabetes?

Aims/hypothesis Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. Methods Within the European Prospective Investigation into Cancer and Nutrition (EPIC...