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Rare cell isolation and recovery on open-channel microfluidic chip

The ability to accurately detect and analyze rare cells in a cell population is critical not only for the study of disease progression but also for next flow cytometry systems in clinical application. Here, we report the development of a prototype device, the ‘Rare cell sorter’, for isolating and recovering single rare cells from whole blood samples. On this device, we utilized...

An angiogenesis platform using a cubic artificial eggshell with patterned blood vessels on chicken chorioallantoic membrane

The chorioallantoic membrane (CAM) containing tiny blood vessels is an alternative to large animals for studies involving angiogenesis and tissue engineering. However, there is no technique to design the direction of growing blood vessels on the CAM at the microscale level for tissue engineering experiments. Here, a methodology is provided to direct blood vessel formation on the...

Retinal vessel model fabricated on a curved surface structure for a simulation of microcannulation

A remarkable number of vitreoretinal surgeries are performed each year despite their difficulty. As a result, a high demand exists for a mock-up simulator of retinal vessels to simulate these surgeries. Thus, we propose an artificial retinal vessel model for simulating microcannulation surgery. Using laser lithography, polydimethylsiloxane molding, and hydraulic transfer...

Egg-in-Cube: Design and Fabrication of a Novel Artificial Eggshell with Functionalized Surface

An eggshell is a porous microstructure that regulates the passage of gases to allow respiration. The chick embryo and its circulatory system enclosed by the eggshell has become an important model for biomedical research such as the control of angiogenesis, cancer therapy, and drug delivery test, because the use of embryo is ethically acceptable and it is inexpensive and small...

Miniaturized load sensor using quartz crystal resonator constructed through microfabrication and bonding

Highly sensitive, wide-measurement-range compact load sensors are desirable for various applications, including measurement of biosignals, manipulation and stiffness measurement of cells, and so on. Conventional load sensors are highly sensitive but have relatively small measurement ranges. A load sensor using an AT-cut quartz crystal resonator (QCR) has superior characteristics...

On-Chip Gel-Valve Using Photoprocessable Thermoresponsive Gel

Microfluidic chips are powerful tools for biochemical experiments. High speed and precise flow control can be achieved by using microvalves on a chip. Several types of microvalves that can be integrated into a microfluidic chip have been reported. Among them, gel microvalves have certain advantages over other valves because of their soft structure, which will contribute to...

Virus Enrichment for Single Virus Infection by Using 3D Insulator Based Dielectrophoresis

Fumihito Arai 0 Suryaprakash Sambhara, Centers for Disease Control and Prevention, United States of America 0 1 Department of Micro-Nano Systems Engineering, Graduate School of Engineering, Nagoya University

A Novel Single Virus Infection System Reveals That Influenza Virus Preferentially Infects Cells in G1 Phase

Background Influenza virus attaches to sialic acid residues on the surface of host cells via the hemagglutinin (HA), a glycoprotein expressed on the viral envelope, and enters into the cytoplasm by receptor-mediated endocytosis. The viral genome is released and transported in to the nucleus, where transcription and replication take place. However, cellular factors affecting the...

Development of a New Rapid Isolation Device for Circulating Tumor Cells (CTCs) Using 3D Palladium Filter and Its Application for Genetic Analysis

Seiji Ito Shuhei Yamamoto Mina Okochi Naoto Kondo Hiroji Iwata Yasushi Yatabe Yoshiyuki Ichinosawa Seichin Kinuta Eisaku Kondo Hiroyuki Honda Fumihito Arai Hayao Nakanishi Michiya Matsusaki, Osaka