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Consensus-based cross-European recommendations for the identification, measurement and valuation of costs in health economic evaluations: a European Delphi study

Objectives Differences between country-specific guidelines for economic evaluations complicate the execution of international economic evaluations. The aim of this study was to develop cross-European recommendations for the identification, measurement and valuation of resource use and lost productivity in economic evaluations using a Delphi procedure. Methods A comprehensive...

Moderate alcohol consumption is associated with lower chronic disease burden expressed in disability-adjusted life years: a prospective cohort study

The relation of alcohol consumption with disease burden remains debated partly due to opposite associations with cardiovascular disease (CVD) and cancer. The relation of alcohol consumption with disease burden expressed in disability-adjusted life years (DALYs) summarizes opposing associations of alcohol consumption on chronic diseases. This study aimed to investigate the...

Cost-Effectiveness of Hepatitis C Treatment for People Who Inject Drugs and the Impact of the Type of Epidemic; Extrapolating from Amsterdam, the Netherlands

Background People who inject drugs (PWID) are disproportionally affected by the hepatitis C virus (HCV) infection. The efficacy of HCV treatment has significantly improved in recent years with the introduction of direct-acting antivirals (DAAs). However, DAAs are more costly than pegylated-interferon and ribavirin (PegIFN/RBV). We aimed to assess the cost-effectiveness of four...

The Effect of Including an Opt-Out Option in Discrete Choice Experiments

Objective to determine to what extent the inclusion of an opt-out option in a DCE may have an effect on choice behaviour and therefore might influence the attribute level estimates, the relative importance of the attributes and calculated trade-offs. Methods 781 Dutch Type 2 Diabetes Mellitus patients completed a questionnaire containing nine choice tasks with an opt-out option...

The Predictive Value of Discrete Choice Experiments in Public Health: An Exploratory Application

3 0 A. Jantine Schuit Department of Health Sciences, EMGO Institute for Health and Care Research, VU University , Amsterdam , The Netherlands 1 J. Veldwijk R. E. J. Neslo G. Ardine de Wit Julius ... Center for Health Sciences and Primary Care, University Medical Center Utrecht , Utrecht , The Netherlands 2 B. H. Salampessy J. Veldwijk (&) A. Jantine Schuit G. Ardine de Wit M. S. Lambooij Centre for

Exposure to Famine at a Young Age and Unhealthy Lifestyle Behavior Later in Life

Background A healthy diet is important for normal growth and development. Exposure to undernutrition during important developmental periods such as childhood and adolescence can have effects later in life. Inhabitants of the west of the Netherlands were exposed to severe undernutrition during the famine in the last winter of the second World War (1944–1945). Objective We...

Type 2 diabetes patients’ preferences and willingness to pay for lifestyle programs: a discrete choice experiment

Background Participation rates of lifestyle programs among type 2 diabetes mellitus (T2DM) patients are less than optimal around the globe. Whereas research shows notable delays in the development of the disease among lifestyle program participants. Very little is known about the relative importance of barriers for participation as well as the willingness of T2DM patients to pay...

Cost-Effectiveness of Preoperative Screening and Eradication of Staphylococcus aureus Carriage

Background Preoperative screening for nasal S. aureus carriage, followed by eradication treatment of identified carriers with nasal mupirocine ointment and chlorhexidine soap was highly effective in preventing deep-seated S. aureus infections. It is unknown how cost-effectiveness of this intervention is affected by suboptimal S. aureus screening. We determined cost-effectiveness...

Association between Lifestyle Factors and Quality-Adjusted Life Years in the EPIC-NL Cohort

The aim of our study was to relate four modifiable lifestyle factors (smoking status, body mass index, physical activity and diet) to health expectancy, using quality-adjusted life years (QALYs) in a prospective cohort study. Data of the prospective EPIC-NL study were used, including 33,066 healthy men and women aged 20–70 years at baseline (1993–7), followed until 31-12-2007 for...

Quantifying Cost-Effectiveness of Controlling Nosocomial Spread of Antibiotic-Resistant Bacteria: The Case of MRSA

Background The costs and benefits of controlling nosocomial spread of antibiotic-resistant bacteria are unknown. Methods We developed a mathematical algorithm to determine cost-effectiveness of infection control programs and explored the dynamical interactions between different epidemiological variables and cost-effectiveness. The algorithm includes occurrence of nosocomial...

Development of Methodology for Disability-Adjusted Life Years (DALYs) Calculation Based on Real-Life Data

Background Disability-Adjusted Life Years (DALYs) have the advantage that effects on total health instead of on a specific disease incidence or mortality can be estimated. Our aim was to address several methodological points related to the computation of DALYs at an individual level in a follow-up study. Methods DALYs were computed for 33,507 men and women aged 20–70 years when...

Willingness to participate in a lifestyle intervention program of patients with type 2 diabetes mellitus: a conjoint analysis

Health and the Environment, Bilthoven , the Netherlands 3 G Ardine de Wit 4 Department of Health Sciences, EMGO Institute for Health and Care Research, VU University , Amsterdam , the Netherlands 8 1 0 2

The cost–utility of haemodiafiltration versus haemodialysis in the Convective Transport Study

Background Despite the growing interest in haemodiafiltration (HDF), there is no information on the costs and cost–utility of this dialysis modality yet. It was therefore our objective to study the cost–utility of HDF versus haemodialysis (HD).

Towards a more efficient diabetes control in primary care: six-monthly monitoring compared with three-monthly monitoring in type 2 diabetes - The EFFIMODI trial. Design of a randomised controlled patient-preference equivalence trial in primary care

Background Scientific evidence for the frequency of monitoring of type 2 diabetes patients is lacking. If three-monthly control in general practice could be reduced to six-monthly control in some patients, this would on the one hand reduce the use of medical services including involvement of practice nurses, and thus reduce costs, and on the other hand alleviate the burden of...

Effects of Population Based Screening for Chlamydia Infections in The Netherlands Limited by Declining Participation Rates

Background A large trial to investigate the effectiveness of population based screening for chlamydia infections was conducted in the Netherlands in 2008–2012. The trial was register based and consisted of four rounds of screening of women and men in the age groups 16–29 years in three regions in the Netherlands. Data were collected on participation rates and positivity rates per...

Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial

Gijsen Eric van Breda G Ardine de Wit Carin D Schrder Evelyn M Monninkhof Eline Lindeman Elsken van der Wall Petra HM Peeters 0 Comprehensive Cancer Center Middle Netherlands , Utrecht , the Netherlands

Differences in quality of life of hemodialysis patients between dialysis centers

Purpose Hemodialysis patients undergo frequent and long visits to the clinic to receive adequate dialysis treatment, medical guidance, and support. This may affect health-related quality of life (HRQOL). Although HRQOL is a very important management aspect in hemodialysis patients, there is a paucity of information on the differences in HRQOL between centers. We set out to assess...

Early recognition of heart failure in patients with diabetes type 2 in primary care. A prospective diagnostic efficiency study. (UHFO-DM2)

Background We hypothesize that the prevalence of unknown heart failure in diabetic patients aged 60 years and over is relatively high (15% or more) and that a cost-effective strategy can be developed to detect heart failure in these patients. The strategy is expected to include some signs and symptoms (such as dyspnoea, orthopnoea, pulmonary crepitations and laterally displaced...

Lifetime Medical Costs of Obesity: Prevention No Cure for Increasing Health Expenditure

Background Obesity is a major cause of morbidity and mortality and is associated with high medical expenditures. It has been suggested that obesity prevention could result in cost savings. The objective of this study was to estimate the annual and lifetime medical costs attributable to obesity, to compare those to similar costs attributable to smoking, and to discuss the...