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Side-to-side asymmetries in landing mechanics from a drop vertical jump test are not related to asymmetries in knee joint laxity following anterior cruciate ligament reconstruction

Purpose Asymmetries in knee joint biomechanics and increased knee joint laxity in patients following anterior cruciate ligament reconstruction (ACLR) are considered risk factors for re-tear or early onset of osteoarthritis. Nevertheless, the relationship between these factors has not been established. The aim of the study was to compare knee mechanics during landing from a...

The Proposed Park in Maine's North Woods: Preferences of Out-of-State Visitors

The proposal to create a new national park and national recreation area in northern Maine has met with much support and also much opposition from within Maine. Over 90 percent of overnight visitors to Maine recreation sites come from out of state but currently there is no information about out-of-state visitors’ preferences for the proposed park. Our research contributes to...

Unexpected Positive Buoyancy in Deep Sea Sharks, Hexanchus griseus, and a Echinorhinus cookei

We do not expect non air-breathing aquatic animals to exhibit positive buoyancy. Sharks, for example, rely on oil-filled livers instead of gas-filled swim bladders to increase their buoyancy, but are nonetheless ubiquitously regarded as either negatively or neutrally buoyant. Deep-sea sharks have particularly large, oil-filled livers, and are believed to be neutrally buoyant in...

Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin

We have carried out a comprehensive analysis of the determinants of human influenza A H3 hemagglutinin evolution. We consider three distinct predictors of evolutionary variation at individual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), Immune Epitope Database (IEDB) epitope sites (as a proxy for host immune bias), and proximity to the...

Constrained Optimization for Addressing Forest-Wide Timber Production

Optimization models are important tools for integrating objectives in forest management planning. Timber management objectives are difficult to address without considering complex environmental conditions, other ownership objectives, and forest management policies. Typically, to learn about management opportunities, model applications involve multiple scenarios and tradeoff...

Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH)

Post-translational modification of lysine residues by NƐ-acylation is an important regulator of protein function. Many large-scale protein acylation studies have assessed relative changes of lysine acylation sites after antibody enrichment using mass spectrometry-based proteomics. Although relative acylation fold-changes are important, this does not reveal site occupancy, or...

Evidence base in guideline generation in diabetes

G. Meyer Faculty of Health, University of Witten/Herdecke , Witten , Germany 2 ) Unit of Health Sciences and Education, University of Hamburg , Martin-Luther-King Platz 6, 20146 Hamburg , Germany ... of the IQWiG from January 2005 until January 2013 and G. Meyer is currently member. Contribution statement IM and GM are equally responsible for the conception, design and drafting of the manuscript

TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis

Toll like receptors (TLR) are key elements of the innate immune response and involved in the recognition of pathogens. To test common and rare TLR variants involved in susceptibility or resistance to infection with Mycobacterium tuberculosis we screened the exons of the genes encoding TLR 1, 2, 4, and the adaptor molecule TIRAP in more than 4500 tuberculosis (TB) cases and...

A Way Forward for Healthcare in Madagascar?

A healthcare utilization survey was conducted as a component of the Typhoid Fever Surveillance in Africa Program (TSAP). The findings of this survey in Madagascar contrasted with those in other sites of the program; namely, only 30% of the population sought healthcare at the government-provided healthcare facilities for fever. These findings promoted us to determine the drivers...

Geographical distribution of complement receptor type 1 variants and their associated disease risk

Background Pathogens exert selective pressure which may lead to substantial changes in host immune responses. The human complement receptor type 1 (CR1) is an innate immune recognition glycoprotein that regulates the activation of the complement pathway and removes opsonized immune complexes. CR1 genetic variants in exon 29 have been associated with expression levels, C1q or C3b...

Salmon Dip

Salmon Dip Brian G. Meyer 0 1 0 This Article is brought to you for free and open access by the College of Agriculture and Life Sciences at Iowa State University Digital Repository. It has been

abiliti® Closed-Loop Gastric Electrical Stimulation System for Treatment of Obesity: Clinical Results with a 27-Month Follow-Up

Background The aim of the study was to evaluate the safety and effectiveness of a novel closed-loop gastric electric stimulation device (abiliti® system) featuring a transgastric sensor to detect food intake and an accelerometer to record physical activity to induce and maintain lifestyle changes to treat obesity. Methods In a prospective, multi-center study, 34 obese subjects...

Integrating Sequence Variation and Protein Structure to Identify Sites under Selection

We present a novel method to identify sites under selection in protein-coding genes. Our method combines the traditional Goldman–Yang model of coding-sequence evolution with the information obtained from the 3D structure of the evolving protein, specifically the relative solvent accessibility (RSA) of individual residues. We develop a random-effects likelihood sites model in...

Charge State Coalescence During Electrospray Ionization Improves Peptide Identification by Tandem Mass Spectrometry

Jesse G. Meyer 0 Elizabeth A. Komives 0 0 Department of Chemistry and Biochemistry, University of California-San Diego , La Jolla, CA 92093-0378, USA We report the effects of supercharging reagents

Simple multiplex PCR assays to detect common pathogens and associated genes encoding for acquired extended spectrum betalactamases (ESBL) or carbapenemases from surgical site specimens in Vietnam

Surgical site infection (SSI) is common in Vietnamese post-operative patients. It contributes to increased morbidity, mortality, hospitalization time and health care expenditure. Bacterial culture is considered the gold standard procedure to identify SSI pathogens and antibiotic resistant properties; however, it can detect microbes that can readily grow and is time-consuming. We...

A Qualitative Study Investigating Experiences, Perceptions, and Healthcare System Performance in Relation to the Surveillance of Typhoid Fever in Madagascar

Background. The burden of typhoid fever (TF) in sub-Saharan Africa is largely unknown but is increasingly thought to be high, given that water and sanitary conditions remain unimproved in many countries. To address this gap in information, the Typhoid Fever Surveillance in Africa Program (TSAP) founded a surveillance system for TF in 10 African countries. This study was a...

Cross-species comparison of site-specific evolutionary-rate variation in influenza haemagglutinin

Austin G. Meyer 0 Eric T. Dawson 0 Claus O. Wilke 0 0 Section of Integrative Biology, Institute for Cellular and Molecular Biology, and Center for Computational Biology and Bioinformatics, The

Predicting Growth Conditions from Internal Metabolic Fluxes in an In-Silico Model of E. coli

A widely studied problem in systems biology is to predict bacterial phenotype from growth conditions, using mechanistic models such as flux balance analysis (FBA). However, the inverse prediction of growth conditions from phenotype is rarely considered. Here we develop a computational framework to carry out this inverse prediction on a computational model of bacterial metabolism...