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Numerical Simulation of Dynamic Tensile Extrusion Test of OFHC Copper

The dynamic tensile extrusion (DTE) test offers unique possibility to probe material response under very large plastic strain, high strain rate and temperature to support constitutive modelling development. From the computational point of view, the DTE test is particularly challenging and a number of issues need to be assessed before proceeding with material modelling...

The idiopathic forms of premature menopause and early menopause show the same genetic pattern

Genetic factors may influence the timing of menopause. Premature ovarian failure (POF) has recently been identified as a genetic entity, but no genetic data are available on early menopause (EM). We investigated 36 patients with EM (age of menopause between 40 and 45 years of age) using cytogenetic and pedigree analysis. In 30 patients of this study the EM was idiopathic and 15...

Inheritance in idiopathic premature ovarian failure: analysis of 71 cases.

Premature ovarian failure is defined as cessation of ovarian function under the age of 40 years and affects approximately 1% of women in the general population. The aetiology of this disorder is still unknown in most cases. Although there have been some reports of familial premature ovarian failure, very little is known about the incidence and inheritance pattern of its...

Mobilisation kinetics of primitive haemopoietic cells following G-CSF with or without chemotherapy for advanced breast cancer

Background: The objective of this study was to determine the optimal conditions for blood progenitor cell harvest for transplantation, with main emphasis on the mobilisation kinetics of primitive, marrow repopulating cells. Patients and methods: Sixteen patients with advanced breast cancer were treated with 4 cycles of dose escalating FAC chemotherapy (5-fluorouracil, adriamycin...

Peripheral blood progenitor cell transplantation: Where do we stand? Chairman's summary of the European School of Oncology Task Force Meeting ‘Peripheral Blood Progenitor Cells’ held September 29–30, 1996

Whether or not peripheral stem cells have an unlimited capacity for self renewal is debated. However, everyday haematopoietic requirements are met by progenitors; and it seems that few ‘real’ stem cells are needed. Although we may not yet have identified these ‘true’ stem cells, for practical purposes the long term culture-initiating cells (LTC-ICs) are a close approximation. To...