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271 papers found.
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TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas

Transgelin-2 (TAGLN2) is a member of the calponin family of actin-bundling proteins that is involved in the regulation of cell morphology, motility, and cell transformation. Here, the clinical significance and potential function of TAGLN2 in malignant gliomas were investigated. Molecular and clinical data was obtained from The Cancer Genome Atlas (TCGA) database. Gene ontology and ...

Study on the radiative decays of \(h_c\) via intermediate meson loops model

Eur. Phys. J. C Study on the radiative decays of hc via intermediate meson loops model Qi Wu 0 Gang Li 0 Yawei Zhang 0 0 College of Physics and Engineering, Qufu Normal University , Qufu 273165

Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates

and the burden on the patient. Thus, Fc-modified mAbs with longer serum half-lives should represent a potent new class of human therapeutics. Author Contributions Conceptualization: Yijun Shen, Gang ... Li. Data curation: Hua Li. Formal analysis: Li Zhao. Funding acquisition: Yong Su. Investigation: Qingsong Guo, Bei Gao. Methodology: Ben Chen. Project administration: Yijun Shen. Resources

Could the observation of X(5568) be a result of the near threshold rescattering effects?

We investigate the invariant mass distributions of \(B_s\pi \) via different rescattering processes. The triangle singularity which appears in the rescattering amplitude may simulate the resonance-like bump around 5568 MeV. However, because the scattering \(B_s^*\pi \rightarrow B_s\pi \) is supposed to be weak, if the pertinent background is much larger, it would be hard to ascribe ...

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis

Haemophilus parasuis is the causative agent of Glasser’s disease in pigs. Cytolethal distending toxin (CDT) is an important virulence factor of H. parasuis. It is composed of three subunits: CdtA, CdtB and CdtC and all were successfully expressed in soluble form in Escherichia coli when the signal peptides were removed. Purified CdtB had DNase activity, i.e. caused DNA double ...

Pyridoxal phosphate synthases PdxS/PdxT are required for Actinobacillus pleuropneumoniae viability, stress tolerance and virulence

Pyridoxal 5’-phosphate (PLP) is an essential cofactor for numerous enzymes involved in a diversity of cellular processes in living organisms. Previous analysis of the Actinobacillus pleuropneumoniae S-8 genome sequence revealed the presence of pdxS and pdxT genes, which are implicated in deoxyxylulose 5-phosphate (DXP)-independent pathway of PLP biosynthesis; however, little is ...

Performance of a modified particle swarm optimization in determining the thickness of the liquid layer outside a well casing pipe

The liquid layer outside a well casing develops from flaws along the cement–casing interface, which have been identified as leakage pathways in wellbores. The thickness of the liquid layer is one of the important parameters for determining cement bond quality. However, it is difficult to accurately determine the thickness of the liquid layer outside a well casing pipe with the ...

T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα

T0001 is a recombinant human TNFR-Fc fusion protein mutant; it exhibits higher affinity to TNFα than etanercept and is now being tested in a Phase 1 study in China (ClinicalTrials.gov Identifier: NCT02481180). T0001 can inhibit the binding of soluble TNFα (sTNFα) or membrane-bound TNFα (mTNFα) to TNF receptors. When bound to mTNFα, the Fc-bearing TNFα antagonists have the potential ...

Development of a SYBR Green I real-time PCR for the detection of the orf virus

Orf is a non-systemic, ubiquitous disease of sheep and goats caused by the orf virus (ORFV). ORFV occasionally causes cutaneous lesions in humans in contact with infected animals. In the present study, a real-time PCR method was established for detection of ORFV using the fluorescent chimeric dye SYBR Green I. Specific primers were designed to target a highly conserved region of ...

Attenuated Actinobacillus pleuropneumoniae double-deletion mutant S-8∆clpP/apxIIC confers protection against homologous or heterologous strain challenge

Gang Li 0 Long Zhou Yanhe Zhang Ning Cui Siguo Liu Chunlai Wang 0 Equal contributors State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice

Eibl. Formal analysis: Hui-Hua Chang, Kazuki Takakura, Hsin-Yuan Su, Allen Mo, Masako Nakanishi, Richard T. Waldron, Samuel W. French, David W. Dawson, Gang Li, Aurelia Lugea, Anna S. Gukovskaya

Correction: Systemic Administration of Allogeneic Mesenchymal Stem Cells Does Not Halt Osteoporotic Bone Loss in Ovariectomized Rats

Yamei Liu Jinfang Zhang Lin Chen Gang Li The following information is missing from the Funding section: Lin Chen (LC) was supported by a grant from the Chongqing City Basic and Frontier Research Project

Characterization and interstrain transfer of prophage pp3 of Pseudomonas aeruginosa

Prophages are major contributors to horizontal gene transfer and drive the evolution and diversification of bacteria. Here, we describe the characterization of a prophage element designated pp3 in the clinical Pseudomonas aeruginosa isolate PA1. pp3 spontaneously excises from the PA1 genome and circularizes at a very high frequency of 25%. pp3 is likely to be a defective prophage ...

Three-Dimensional Visualization and Imaging of the Entry Tear and Intimal Flap of Aortic Dissection Using CT Virtual Intravascular Endoscopy

Aims Conventional computed tomography (CT) approaches provides limited visualization of the entire endoluminal changes of aortic dissection (AD), which is essential for its treatment. As an important supplement, three-dimensional CT virtual intravascular endoscopy (VIE) can show relevant details. This study aims to determine the value of VIE in displaying the entry tear and intimal ...

Infinite horizon linear quadratic optimal control for stochastic difference time-delay systems

Gang Li Ming Chen The aim of this paper is to investigate the infinite horizon linear quadratic (LQ) optimal control for stochastic time-delay difference systems with both state and control

Negative pressure irrigation and endoscopic necrosectomy through man-made sinus tract in infected necrotizing pancreatitis: a technical report

Background In recent years, a step-up approach based on minimally invasive techniques was recommended by latest guidelines as initial invasive treatment for infected pancreatic necrosis (IPN). In this study, we aimed to describe a novel step-up approach for treating IPN consisting of four steps including negative pressure irrigation (NPI) and endoscopic necrosectomy (ED) as a ...

Osthole Promotes Endochondral Ossification and Accelerates Fracture Healing in Mice

Zhongrong Zhang, Wing Nang Leung, Gang Li, Yau Ming Lai and Chun Wai Chan declare that they have no conflict of interest. Ethical Approval All applicable international, national, and/or institutional