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Oligopeptides as full-length New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors

‘Superbug’ bacteria producing NDM-1 enzyme causing wide public concern were first detected in a patient who visited India in 2008. It's an effective approach to combining β-lactam antibiotics with NDM-1 inhibitor for treating NDM-1 producing strain infection. In our research, we designed ten oligopeptides, tested IC50 values against NDM-1 enzyme, determined the MIC values of ...

Integrated Multiple “-omics” Data Reveal Subtypes of Hepatocellular Carcinoma

Hepatocellular carcinoma is one of the most heterogeneous cancers, as reflected by its multiple grades and difficulty to subtype. In this study, we integrated copy number variation, DNA methylation, mRNA, and miRNA data with the developed “cluster of cluster” method and classified 256 HCC samples from TCGA (The Cancer Genome Atlas) into five major subgroups (S1-S5). We observed ...

The impact of DO and salinity on microbial community in poly(butylene succinate) denitrification reactors for recirculating aquaculture system wastewater treatment

The interactions between environmental factors and bacterial community shift in solid-phase denitrification are crucial for optimum operation of a reactor and to achieve maximum treatment efficiency. In this study, Illumina high-throughput sequencing was applied to reveal the effects of different operational conditions on bacterial community distribution of three continuous ...

CD117+CD44+ Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway

0 Gang Liu Bingyin Shi 0 Enqi Liu Tie Liu 0 0 Immunology and Tumor Research Instituted, the First Affiliate Hospital, Xi'an Jiaotong University Health Science Center , Xi'an, Shaanxi 710061 , People's

Tensile Properties of Hybrid Fiber-Reinforced Reactive Powder Concrete After Exposure to Elevated Temperatures

0 Gang Liu 0 0 Mechanics Engineering Department, Shijiazhuang Tiedao University , Shijiazhuang 050043 , People's Republic of China The paper presents a research project on the tensile properties of

Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue

Background The causative role of the pro-inflammatory cytokine IL-6 in prostate cancer progression has been well established at molecular level. However, whether and how IL-6 may play a role in prostate cancer risk and development is not well defined. One limitation factor to acquiring this knowledge is the lack of appropriate animal models. Methods We generated a novel line of ...

Investigation of availability of a high throughput screening method for predicting butanol solvent -producing ability of Clostridium beijerinckii

Gang Liu 0 Furong Tan 1 0 Sichuan Academy of Grassland Science , Xipu Chengdu, 611731 Sichuan , Peoples Republic of China 1 Biogas Institute of Ministry of Agriculture , Chengdu 610041, Sichuan

Effect of Sling Exercise Training on Balance in Patients with Stroke: A Meta-Analysis

meta-analyses . Lancet 352 : 609 ± 613 . doi: 10 .1016/S0140- 6736 ( 98 ) 01085 -X PMID: 9746022 41. Gang Liu , Junqi Chen, Qiyuan Peng . Basic and clinical of sling exercise therapy . 2014 Nov

Erratum to: Hausdorffness for Lie algebra homology of Schwartz spaces and applications to the comparison conjecture

mistake in [2, Definition 1.1.1] hints to a wrong resolution of this ambiguity, in particular in [2, Theorem D]. This result entered in the proof of Lemma 3.2.1 of [1]. Gang Liu - In [2] the terms “real

Characteristics and outcomes of cryptococcal meningitis in HIV seronegative children in Beijing, China, 2002–2013

Background Data regarding HIV-seronegative pediatric patients with cryptococcal meningitis (CM) have been very limited. Methods We retrospectively reviewed non-HIV-infected in patients with CM from January 2002 through December 2013 in Beijing Children’s Hospital. Records of the all patients were obtained and compared. Results The 34 children had a median age of 5.6 years. Most of ...

New inexact explicit thresholding/shrinkage formulas for inverse problems with overlapping group sparsity

. All authors read and approved the final manuscript. Acknowledgements The work of Gang Liu, Ting-Zhu Huang, and Jun Liu was supported by the 973 Program (2013CB329404), NSFC (61370147), and Fundamental

Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials

Background Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome with the main characteristic of diffuse liver cells with fatty changes. The clinical evolution of NAFLD includes simple non-alcoholic fatty liver, non-alcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis, and even hepatocellular carcinoma. Methods and Findings We conducted this review to identify ...

In situ catalytic upgrading of heavy crude oil through low-temperature oxidation

The low-temperature catalytic oxidation of heavy crude oil (Xinjiang Oilfield, China) was studied using three types of catalysts including oil-soluble, water-soluble, and dispersed catalysts. According to primary screening, oil-soluble catalysts, copper naphthenate and manganese naphthenate, are more attractive, and were selected to further investigate their catalytic performance ...

LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hAβPPswe/PS1ΔE9 transgenic mice

Background Accumulating evidence implicates the neuroendocrine immunomodulation (NIM) network in the physiopathological mechanism of Alzheimer’s disease (AD). Notably, we previously revealed that the NIM network is dysregulated in the PrP-hAβPPswe/PS1ΔE9 (APP/PS1) transgenic mouse model of AD. Methods After treatment with a novel Liuwei Dihuang formula (LW-AFC), mice were ...

Quantification of plasmid DNA reference materials for Shiga toxin-producing Escherichia coli based on UV, HR-ICP-MS and digital PCR

Background The accuracy and metrology traceability of DNA quantification is becoming a critical theme in many fields, including diagnosis, forensic analysis, microorganism detection etc. Thus the research of DNA reference materials (RMs) and consistency of DNA quantification methods has attracted considerable research interest. Results In this work, we developed 3 plasmid candidate ...

The role of long-term label-retaining cells in the regeneration of adult mouse kidney after ischemia/reperfusion injury

Background Label-retaining cells (LRCs) have been recognized as rare stem and progenitor-like cells, but their complex biological features in renal repair at the cellular level have never been reported. This study was conducted to evaluate whether LRCs in kidney are indeed renal stem/progenitor cells and to delineate their potential role in kidney regeneration. Methods We utilized ...

Caspase-Dependent and Caspase-Independent Pathways Are Involved in Cadmium-Induced Apoptosis in Primary Rat Proximal Tubular Cell Culture

We designed this study to investigate whether cadmium induces caspase-independent apoptosis and to investigate the relationship between the caspase-dependent and caspase-independent apoptotic pathways. Cadmium (1.25–2.5 μM) induced oxidative stress in rat proximal tubular (rPT) cells, as seen in the reactive oxygen species levels; N-acetylcysteine prevented this. Cyclosporin A ...

Role of New Nature Reserve in Assisting Endangered Species Conservation - Case Study of Giant Pandas in the Northern Qionglai Mountains, China

The creation of nature reserves is the most direct way to save endangered species populations and their habitat. Development of the giant panda (Ailuropoda melanoleuca) nature reserve network in China was initiated in the 1960s, though the effort to create new reserves boomed considerably after the year 2000. Given this rapid development of protected areas in panda habitats, and ...

DNAJB13, a type II HSP40 family member, localizes to the spermatids and spermatozoa during mouse spermatogenesis

Background Hundreds of HSP40s derived from various species have been identified, of which several proteins are involved in spermatogenesis. DNAJB13 is a type II HSP40/DnaJ protein. In a previous study, we cloned mouse Dnajb13, which is up-regulated in cryptorchidism. To date, however, little is known about the localization and functions of DNAJB13 during spermatogenesis. This study ...