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41 papers found.
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Identification and genetic characterization of hepacivirus and pegivirus in commercial equine serum products in China

: Gang Lu. S1 Fig. RT-PCR result of EqHV, EPgV and TDAV in commercial equine sera for cell culFormal analysis: Ji Huang, Qiliang Yang, Haibin Xu, Peixin Wu, Cheng Fu. Funding acquisition: Shoujun Li ... . Investigation: Gang Lu. Project administration: Gang Lu, Shoujun Li. Resources: Shoujun Li. Supervision: Shoujun Li. Validation: Gang Lu, Ji Huang, Qiliang Yang, Haibin Xu, Peixin Wu, Cheng Fu. Visualization

Plasma miR-124 Is a Promising Candidate Biomarker for Human Intracerebral Hemorrhage Stroke

detection and predictive prognosis of human ICH. Stroke; Intracerebral hemorrhage (ICH); Biomarker; Plasma miRNAs; miR-124 - Zifeng Wang and Gang Lu contributed equally to this work. Introduction Stroke

High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel function, patch clamp electrophysiology is considered the gold standard by providing the ultimate precision and flexibility. However, its utility in ion channel drug discovery is impeded by low throughput. Additionally, ...

The distribution and function of human memory T cell subsets in lung cancer

The distribution and function of T lymphocytes in human lung cancer remain limited. In this study, we investigated the properties of human T cell subsets in the blood of non-small cell lung cancer (NSCLC) patients. We found a relatively normal level of CD4+ subsets in the blood of NSCLC patients, but CD8+ effector T cells increased and CD8+ effector memory cells declined compared ...

Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy

Glioblastoma is a common malignant brain tumor and it is refractory to therapy because it usually contains a mixture of cell types. The tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been shown to induce apoptosis in a range of tumor cell types. Previously, we found that two human glioblastoma cell lines are resistant to TRAIL, while lovastatin sensitizes these ...

Protection via a ROM4 DNA vaccine and peptide against Toxoplasma gondii in BALB/c mice

Background Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite with a broad host range including most warm-blooded animals, including humans. T. gondii surface antigen 1 (SAG1) is a well-characterized T. gondii antigen. T. gondii expresses five nonmitochondrial rhomboid intramembrane proteases, TgROM1-5. TgROM4 is uniformly distributed on the surface of T. ...

Identification of miRNAs and their targets through high-throughput sequencing and degradome analysis in male and female Asparagus officinalis

Background MicroRNAs (miRNAs), a class of non-coding small RNAs (sRNAs), regulate various biological processes. Although miRNAs have been identified and characterized in several plant species, miRNAs in Asparagus officinalis have not been reported. As a dioecious plant with homomorphic sex chromosomes, asparagus is regarded as an important model system for studying mechanisms of ...

Additive functional inequalities in Banach spaces

In this paper, we prove the Hyers-Ulam stability of the following function inequalities: in Banach spaces.MSC: 39B62, 39B52, 46B25.

Genome-wide identification of MAPK, MAPKK, and MAPKKK gene families and transcriptional profiling analysis during development and stress response in cucumber

Background The mitogen-activated protein kinase (MAPK) cascade consists of three types of reversibly phosphorylated kinases, namely, MAPK, MAPK kinase (MAPKK/MEK), and MAPK kinase kinase (MAPKKK/MEKK), playing important roles in plant growth, development, and defense response. The MAPK cascade genes have been investigated in detail in model plants, including Arabidopsis, rice, and ...

Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) occurs more frequently in men than in women. It is commonly agreed that estrogen plays important roles in suppressing HCC development, however, the underlying mechanism remains largely unknown. Since estrogen is mainly metabolized in liver and its metabolites affect cell proliferation, we sought to investigate if the liver-specific cytochrome P450 1A2 ...

International Workshop on Materials Design Process: Thermodynamics, Kinetics and Microstructure Control

0 Xiao-Gang Lu, Professor Shanghai University , Shanghai, P.R. China 1 Jose M. Torralba, Professor IMDEA Materials Institute , Madrid , Spain Universidad Carlos III Madrid , Madrid, Spain 2 Symposium

Generic diffeomorphisms with weak limit shadowing

In this paper, we show that if a C 1 -generic diffeomorphism has the weak limit shadowing property on the chain recurrent set, then the diffemorphism satisfies Axiom A and the no-cycle condition. MSC:37C50, 37D30.

Genome-wide identification and transcriptional profiling analysis of auxin response-related gene families in cucumber

0 Jie Wang 0 Gang Lu 0 0 Key Laboratory of Horticultural Plant Growth, Development and Biotechnology, Agricultural Ministry of China, Department of Horticulture, Zhejiang University , Zijingang Campus

Generic diffeomorphisms with weak limit shadowing

In this paper, we show that if a C 1 -generic diffeomorphism has the weak limit shadowing property on the chain recurrent set, then the diffemorphism satisfies Axiom A and the no-cycle condition.MSC: 37C50, 37D30.

Effect of controlled rolling/controlled cooling parameters on microstructure and mechanical properties of the novel pipeline steel

The study of controlled rolling/controlled cooling process parameters which affect the microstructure and mechanical properties of a novel pipeline steel have been optimized by the orthogonal experiment with four factors and three levels in this paper. However, the parameters of thermo-mechanical control process (TMCP) optimized by the Gleeble-3500 hot simulator could not satisfy ...

Members of the tomato FRUITFULL MADS-box family regulate style abscission and fruit ripening

The tomato (Solanum lycopersicum) protein MADS-RIN plays important roles in fruit ripening. In this study, the functions of two homologous tomato proteins, FUL1 and FUL2, which contain conserved MIKC domains that typify plant MADS-box proteins, and which interact with MADS-RIN, were analysed. Transgenic functional analysis showed that FUL1 and FUL2 function redundantly in fruit ...

Circulating microRNA 132-3p and 324-3p Profiles in Patients after Acute Aneurysmal Subarachnoid Hemorrhage

Background Aneurysmal subarachnoid hemorrhage (SAH) is a highly morbid and fatal condition with high rate of cognitive impairment and negative impact in quality of life among survivors. Delayed cerebral infarction (DCI) is one the major factors for these negative outcomes. In this study we compared the circulating microRNA profiles of SAH patients and healthy individuals, and the ...

IRE1 Phosphatase PP2Ce Regulates Adaptive ER Stress Response in the Postpartum Mammary Gland

We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress. In the present report, we found that the PP2Ce protein is highly expressed in lactating epithelium of the mammary gland. Loss of ...

Molecular Mechanisms of Regulation and Action of microRNA-199a in Testicular Germ Cell Tumor and Glioblastomas

MicroRNA-199a (miRNA-199a) has been shown to have comprehensive functions and behave differently in different systems and diseases. It is encoded by two loci in the human genome, miR-199a-1 in chromosome 19 and miR-199a-2 in chromosome 1. Both loci give rise to the same miRNAs (miR-199a-5p and miR-199a-3p). The cause of the diverse action of the miRNA in different systems is not ...

Genome-Wide Identification of MAPKK and MAPKKK Gene Families in Tomato and Transcriptional Profiling Analysis during Development and Stress Response

Mitogen-activated protein kinase (MAPK) cascades have important functions in plant growth, development, and response to various stresses. The MAPKK and MAPKKK gene families in tomato have never been systematically analyzed. In this study, we performed a genome-wide analysis of the MAPKK and MAPKKK gene families in tomato and identified 5 MAPKK genes and 89 MAPKKK genes. ...