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Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients

Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients Gengyan Xiong,1,* Lin Yao,1,* Peng Hong,1,* Li Yang,2 Weimin Ci,3 Libo

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

Background5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases. The loss of 5hmC has been identified as a hallmark of most types of cancer and is related to tumorigenesis and progression. However, the role of 5hmC in bladder cancer is seldom investigated. Vitamin C was recently...

Impact of aristolochic acid exposure on oncologic outcomes of upper tract urothelial carcinoma after radical nephroureterectomy

Lin,1–3 Xuesong Li,1–3 Gengyan Xiong,1–3 Dong Fang,1–3 Liqun Zhou1–3 1Department of Urology, Peking University First Hospital, 2Institute of Urology, Peking University, 3National Urological Cancer

Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation

Background Aberrant methylation of genes is one of the most common epigenetic modifications involved in the development of urothelial carcinoma. However, it is unknown the predictive role of methylation to contralateral new upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). We retrospectively investigated the predictive role of DNA methylation and...

High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

Background To analyze the expression of karyopherin alpha 2 (KPNA2) in upper tract urothelial carcinoma (UTUC) and to investigate whether the KPNA2 expression provides additional prognostic information following radical nephroureterectomy (RNU). Methods A tissue microarray (TMA) containing samples from 176 patients with UTUC who underwent RNU at our institute was analyzed for...