Swati Mohapatra & George A. Calin The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA Swati Mohapatra Department of Experimental ... Center, Houston, TX, USA George A. Calin Life Science Plaza, Suite: LSP9.3012, 2130 W, Holcombe Blvd, Ste. 910, Houston, TX, 77030, USA George A. Calin AuthorsSwati Mohapatra View author publications
Anderson Cancer Center, Houston, TX, USA George A. Calin School of Biomedical Sciences, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong Kit San Yuen & Dong Yan Jin AuthorsMin Yue Zhang ... View author publications You can also search for this author in PubMed Google Scholar George A. Calin View author publications You can also search for this author in PubMed Google Scholar Kit
The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early phase 3 clinical trials. The therapeutic indication of immune checkpoint inhibitors expanded in the last years, but still remains...
Barbara Pardini in:PubMed • Google Scholar Search for Mihnea P. Dragomir in:PubMed • Google Scholar Search for Anthony Lucci in:PubMed • Google Scholar Search for George A. Calin in:PubMed • Google ... Correspondence to Mihnea P. Dragomir or Anthony Lucci or George A. Calin. Ethics declarations Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Competing
Renal cell carcinoma (RCC) is a relatively rare malignancy of the urinary tract system. RCC is a heterogenous disease in terms of underlying histology and its associated underlying pathobiology, prognosis and treatment schedule. The most prevalent histological RCC subtype is clear-cell renal cell carcinoma (ccRCC), accounting for about 70−80% of all RCCs. Though the pathobiology...
Because of the complexity of the blood-brain barrier (BBB), brain tumors, especially the most common and aggressive primary malignant tumor type arising from the central nervous system (CNS), glioblastoma, remain an essential challenge regarding diagnostic and treatment. There are no approved circulating diagnostic or prognostic biomarkers, nor novel therapies like immune...
BackgroundmiR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic miR-340-5p is a tumor suppressor miRNA epigenetically silenced by promoter DNA methylation of its host gene in multiple myeloma.ResultsBy pyrosequencing-confirmed...
Although hematopoietic stem cell (HSC) therapy for hematological diseases can lead to a good outcome from the clinical point of view, the limited number of ideal donors, the comorbidity of patients and the increasing number of elderly patients may limit the application of this therapy. HSCs can be generated from induced pluripotent stem cells (iPSCs), which requires the...
BiotechHealth PhD Programme and MIA to L'Oreal-UNESCO-FCT for the Medal of Honor for Women in Science. Competing interests: Dr. George A. Calin and Dr. Mario Adolfo Barbosa are co-authors of this manuscript and ... Almeida. Data curation: Joao Paulo Bras. Formal analysis: Joao Paulo Bras, Andreia Machado Silva. Funding acquisition: George A. Calin, Mario Adolfo Barbosa. Investigation: Joao Paulo Bras, Andreia
The role of immune response is emerging as a key factor in the complex multistep process of cancer. Tumor microenvironment contains different types of immune cells, which contribute to regulate the fine balance between anti and protumor signals. In this context, mechanisms of crosstalk between cancer and immune cells remain to be extensively elucidated. Interestingly, microRNAs...
Contributions Conceptualization: Catalin Vasilescu, Sai-Ching Jim Yeung, George A. Calin. Data curation: Catalin Vasilescu, Mihnea Dragomir, Mihai Tanase, Raluca Purnichescu-Purtan, Meng Chen. 17 / 21 Formal ... analysis: Catalin Vasilescu, Mihnea Dragomir, Mihai Tanase, Raluca Purnichescu Purtan, Meng Chen. Funding acquisition: George A. Calin. Methodology: Catalin Vasilescu, Mihnea Dragomir. Project
Paloma del C. Monroig 0 George A. Calin 0 0 P. d. C. Monroig G. A. Calin (&) Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center , Houston, TX 77030, USA
A report on the Keystone Symposia on MicroRNAs and Cancer, Keystone, Colorado, USA, 10-15 June 2009.
Background The response to endotoxin (LPS), and subsequent signal transduction lead to the production of cytokines such as tumor necrosis factor-α (TNF-α) by innate immune cells. Cells or organisms pretreated with endotoxin enter into a transient state of hyporesponsiveness, referred to as endotoxin tolerance (ET) which represents a particular case of negative preconditioning...
The response to endotoxin (LPS), and subsequent signal transduction lead to the production of cytokines such as tumor necrosis factor-α (TNF-α) by innate immune cells. Cells or organisms pretreated with endotoxin enter into a transient state of hyporesponsiveness, referred to as endotoxin tolerance (ET) which represents a particular case of negative preconditioning. Despite...
Orchestration of bone repair processes requires crosstalk between different cell populations, including immune cells and mesenchymal stem/stromal cells (MSC). Extracellular vesicles (EV) as mediators of these interactions remain vastly unexplored. Here, we aimed to determine the mechanism of MSC recruitment by Dendritic Cells (DC), hypothesising that it would be mediated by EV...
A report on the Keystone Symposia on MicroRNAs and Cancer, Keystone, Colorado, USA, 10-15 June 2009.
MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors. A recent study has reported that the miRNAs miR-221 and miR-222 are involved in the promotion of an aggressive basal-like phenotype in breast cancer, functioning downstream of the RAS pathway and triggering epithelial-to-mesenchymal transition. These new insights into the roles of miR-221/222 in breast...
MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors. A recent study has reported that the miRNAs miR-221 and miR-222 are involved in the promotion of an aggressive basal-like phenotype in breast cancer, functioning downstream of the RAS pathway and triggering epithelial-to-mesenchymal transition. These new insights into the roles of miR-221/222 in breast...
